Prescription Opioid Exposures Among Children and Adolescents in the United States: 2000-2015
This study analyzes and compares exposures to prescription opioids among children and adolescents younger than 20 years old in the United States. Data from the National Poison Data System for 2000 through 2015 were analyzed. Poison control centers received reports of 188 468 prescription opioid expo...
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| Veröffentlicht in: | Pediatrics (Evanston) 2017-04, Vol.139 (4), p.e20163382 |
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| container_title | Pediatrics (Evanston) |
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| creator | Allen, Jakob D Casavant, Marcel J Spiller, Henry A Chounthirath, Thiphalak Hodges, Nichole L Smith, Gary A |
| description | This study analyzes and compares exposures to prescription opioids among children and adolescents younger than 20 years old in the United States.
Data from the National Poison Data System for 2000 through 2015 were analyzed.
Poison control centers received reports of 188 468 prescription opioid exposures among children aged |
| doi_str_mv | 10.1542/peds.2016-3382 |
| format | Article |
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Data from the National Poison Data System for 2000 through 2015 were analyzed.
Poison control centers received reports of 188 468 prescription opioid exposures among children aged <20 years old from 2000 through 2015. The annual number and rate of exposures increased early in the study period, but declined after 2009, except for buprenorphine exposures, which increased during the last 3 study years. Hydrocodone accounted for the largest proportion of exposures (28.7%), and 47.1% of children exposed to buprenorphine were admitted to a health care facility (HCF). The odds of being admitted to an HCF were higher for teenagers than for children aged 0 to 5 years (odds ratio [OR]: 2.86; 95% confidence interval [CI]: 2.78-2.94) or children aged 6 to 12 years (OR: 6.62; 95% CI: 6.06-7.02). Teenagers also had greater odds of serious medical outcomes than did children aged 0 to 5 years (OR: 3.03; 95% CI: 2.92-3.15) or children aged 6 to 12 years (OR: 4.59; 95% CI: 4.21-5.00). The rate of prescription opioid-related suspected suicides among teenagers increased by 52.7% during the study period.
Prescription opioid-related HCF admissions and serious medical outcomes were higher among teenagers. Contrary to trends for other prescription opioids, exposures to buprenorphine have increased in recent years; children aged 0 to 5 years accounted for almost 90% of buprenorphine exposures. These findings indicate that additional prevention efforts are needed.</description><identifier>ISSN: 0031-4005</identifier><identifier>EISSN: 1098-4275</identifier><identifier>DOI: 10.1542/peds.2016-3382</identifier><identifier>PMID: 28320869</identifier><identifier>CODEN: PEDIAU</identifier><language>eng</language><publisher>United States: American Academy of Pediatrics</publisher><subject>Adolescent ; Analgesics, Opioid - administration & dosage ; Analgesics, Opioid - adverse effects ; Analysis ; Child ; Child, Preschool ; Children & youth ; Databases, Factual ; Drugs ; Female ; Humans ; Infant ; Male ; Narcotics ; Opioid-Related Disorders - epidemiology ; Opioid-Related Disorders - therapy ; Opioids ; Patient outcomes ; Pediatrics ; Poison Control Centers - statistics & numerical data ; Prescribing ; Prescription Drug Misuse - statistics & numerical data ; Prescription drugs ; Prescriptions (Drugs) ; Prescriptions - statistics & numerical data ; Teenagers ; United States ; Young Adult</subject><ispartof>Pediatrics (Evanston), 2017-04, Vol.139 (4), p.e20163382</ispartof><rights>Copyright © 2017 by the American Academy of Pediatrics.</rights><rights>Copyright American Academy of Pediatrics Apr 2017</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c401t-c5603bfc576508438d8ea0dee75194d1e2bbdda44d7e5dc8a30b12df110c16a23</citedby><cites>FETCH-LOGICAL-c401t-c5603bfc576508438d8ea0dee75194d1e2bbdda44d7e5dc8a30b12df110c16a23</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28320869$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Allen, Jakob D</creatorcontrib><creatorcontrib>Casavant, Marcel J</creatorcontrib><creatorcontrib>Spiller, Henry A</creatorcontrib><creatorcontrib>Chounthirath, Thiphalak</creatorcontrib><creatorcontrib>Hodges, Nichole L</creatorcontrib><creatorcontrib>Smith, Gary A</creatorcontrib><title>Prescription Opioid Exposures Among Children and Adolescents in the United States: 2000-2015</title><title>Pediatrics (Evanston)</title><addtitle>Pediatrics</addtitle><description>This study analyzes and compares exposures to prescription opioids among children and adolescents younger than 20 years old in the United States.
Data from the National Poison Data System for 2000 through 2015 were analyzed.
Poison control centers received reports of 188 468 prescription opioid exposures among children aged <20 years old from 2000 through 2015. The annual number and rate of exposures increased early in the study period, but declined after 2009, except for buprenorphine exposures, which increased during the last 3 study years. Hydrocodone accounted for the largest proportion of exposures (28.7%), and 47.1% of children exposed to buprenorphine were admitted to a health care facility (HCF). The odds of being admitted to an HCF were higher for teenagers than for children aged 0 to 5 years (odds ratio [OR]: 2.86; 95% confidence interval [CI]: 2.78-2.94) or children aged 6 to 12 years (OR: 6.62; 95% CI: 6.06-7.02). Teenagers also had greater odds of serious medical outcomes than did children aged 0 to 5 years (OR: 3.03; 95% CI: 2.92-3.15) or children aged 6 to 12 years (OR: 4.59; 95% CI: 4.21-5.00). The rate of prescription opioid-related suspected suicides among teenagers increased by 52.7% during the study period.
Prescription opioid-related HCF admissions and serious medical outcomes were higher among teenagers. Contrary to trends for other prescription opioids, exposures to buprenorphine have increased in recent years; children aged 0 to 5 years accounted for almost 90% of buprenorphine exposures. These findings indicate that additional prevention efforts are needed.</description><subject>Adolescent</subject><subject>Analgesics, Opioid - administration & dosage</subject><subject>Analgesics, Opioid - adverse effects</subject><subject>Analysis</subject><subject>Child</subject><subject>Child, Preschool</subject><subject>Children & youth</subject><subject>Databases, Factual</subject><subject>Drugs</subject><subject>Female</subject><subject>Humans</subject><subject>Infant</subject><subject>Male</subject><subject>Narcotics</subject><subject>Opioid-Related Disorders - epidemiology</subject><subject>Opioid-Related Disorders - therapy</subject><subject>Opioids</subject><subject>Patient outcomes</subject><subject>Pediatrics</subject><subject>Poison Control Centers - statistics & numerical data</subject><subject>Prescribing</subject><subject>Prescription Drug Misuse - statistics & numerical data</subject><subject>Prescription drugs</subject><subject>Prescriptions (Drugs)</subject><subject>Prescriptions - statistics & numerical data</subject><subject>Teenagers</subject><subject>United States</subject><subject>Young Adult</subject><issn>0031-4005</issn><issn>1098-4275</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkU1r3DAQhkVpaTZprz0WQS-9eDP6suXeliVNAoEttLkVhGzNbhS8kmvJkPz7ymzaQ05z0PNqHuYl5BODNVOSX47o0poDqyshNH9DVgxaXUneqLdkBSBYJQHUGTlP6REApGr4e3LGteCg63ZFfv-YMPWTH7OPge5GH72jV09jTHN5oJtjDAe6ffCDmzBQGxzduDiUCIacqA80PyC9Dz6joz-zzZi-UV4WVcVJfSDv9nZI-PFlXpD771e_tjfV3e76dru5q3oJLFe9qkF0-141tQIthXYaLTjERrFWOoa865yzUroGleu1FdAx7vaMQc9qy8UF-Xr6d5zinxlTNkdfDIfBBoxzMkw3bV2LFmRBv7xCH-M8hWJXqBbKUZRcqOpEHeyAxoc-hoxPuY_DgAc0RX67MxvZai1LYBFYn_h-iilNuDfj5I92ejYMzNKTWXoyS09m6akEPr9ozN0R3X_8XzHiLyOqi4Y</recordid><startdate>201704</startdate><enddate>201704</enddate><creator>Allen, Jakob D</creator><creator>Casavant, Marcel J</creator><creator>Spiller, Henry A</creator><creator>Chounthirath, Thiphalak</creator><creator>Hodges, Nichole L</creator><creator>Smith, Gary A</creator><general>American Academy of Pediatrics</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7TS</scope><scope>7U9</scope><scope>H94</scope><scope>K9.</scope><scope>M7N</scope><scope>NAPCQ</scope><scope>U9A</scope><scope>7X8</scope></search><sort><creationdate>201704</creationdate><title>Prescription Opioid Exposures Among Children and Adolescents in the United States: 2000-2015</title><author>Allen, Jakob D ; Casavant, Marcel J ; Spiller, Henry A ; Chounthirath, Thiphalak ; Hodges, Nichole L ; Smith, Gary A</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c401t-c5603bfc576508438d8ea0dee75194d1e2bbdda44d7e5dc8a30b12df110c16a23</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Adolescent</topic><topic>Analgesics, Opioid - administration & dosage</topic><topic>Analgesics, Opioid - adverse effects</topic><topic>Analysis</topic><topic>Child</topic><topic>Child, Preschool</topic><topic>Children & youth</topic><topic>Databases, Factual</topic><topic>Drugs</topic><topic>Female</topic><topic>Humans</topic><topic>Infant</topic><topic>Male</topic><topic>Narcotics</topic><topic>Opioid-Related Disorders - epidemiology</topic><topic>Opioid-Related Disorders - therapy</topic><topic>Opioids</topic><topic>Patient outcomes</topic><topic>Pediatrics</topic><topic>Poison Control Centers - statistics & numerical data</topic><topic>Prescribing</topic><topic>Prescription Drug Misuse - statistics & numerical data</topic><topic>Prescription drugs</topic><topic>Prescriptions (Drugs)</topic><topic>Prescriptions - statistics & numerical data</topic><topic>Teenagers</topic><topic>United States</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Allen, Jakob D</creatorcontrib><creatorcontrib>Casavant, Marcel J</creatorcontrib><creatorcontrib>Spiller, Henry A</creatorcontrib><creatorcontrib>Chounthirath, Thiphalak</creatorcontrib><creatorcontrib>Hodges, Nichole L</creatorcontrib><creatorcontrib>Smith, Gary A</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Physical Education Index</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>Pediatrics (Evanston)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Allen, Jakob D</au><au>Casavant, Marcel J</au><au>Spiller, Henry A</au><au>Chounthirath, Thiphalak</au><au>Hodges, Nichole L</au><au>Smith, Gary A</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Prescription Opioid Exposures Among Children and Adolescents in the United States: 2000-2015</atitle><jtitle>Pediatrics (Evanston)</jtitle><addtitle>Pediatrics</addtitle><date>2017-04</date><risdate>2017</risdate><volume>139</volume><issue>4</issue><spage>e20163382</spage><pages>e20163382-</pages><issn>0031-4005</issn><eissn>1098-4275</eissn><coden>PEDIAU</coden><abstract>This study analyzes and compares exposures to prescription opioids among children and adolescents younger than 20 years old in the United States.
Data from the National Poison Data System for 2000 through 2015 were analyzed.
Poison control centers received reports of 188 468 prescription opioid exposures among children aged <20 years old from 2000 through 2015. The annual number and rate of exposures increased early in the study period, but declined after 2009, except for buprenorphine exposures, which increased during the last 3 study years. Hydrocodone accounted for the largest proportion of exposures (28.7%), and 47.1% of children exposed to buprenorphine were admitted to a health care facility (HCF). The odds of being admitted to an HCF were higher for teenagers than for children aged 0 to 5 years (odds ratio [OR]: 2.86; 95% confidence interval [CI]: 2.78-2.94) or children aged 6 to 12 years (OR: 6.62; 95% CI: 6.06-7.02). Teenagers also had greater odds of serious medical outcomes than did children aged 0 to 5 years (OR: 3.03; 95% CI: 2.92-3.15) or children aged 6 to 12 years (OR: 4.59; 95% CI: 4.21-5.00). The rate of prescription opioid-related suspected suicides among teenagers increased by 52.7% during the study period.
Prescription opioid-related HCF admissions and serious medical outcomes were higher among teenagers. Contrary to trends for other prescription opioids, exposures to buprenorphine have increased in recent years; children aged 0 to 5 years accounted for almost 90% of buprenorphine exposures. These findings indicate that additional prevention efforts are needed.</abstract><cop>United States</cop><pub>American Academy of Pediatrics</pub><pmid>28320869</pmid><doi>10.1542/peds.2016-3382</doi><oa>free_for_read</oa></addata></record> |
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| subjects | Adolescent Analgesics, Opioid - administration & dosage Analgesics, Opioid - adverse effects Analysis Child Child, Preschool Children & youth Databases, Factual Drugs Female Humans Infant Male Narcotics Opioid-Related Disorders - epidemiology Opioid-Related Disorders - therapy Opioids Patient outcomes Pediatrics Poison Control Centers - statistics & numerical data Prescribing Prescription Drug Misuse - statistics & numerical data Prescription drugs Prescriptions (Drugs) Prescriptions - statistics & numerical data Teenagers United States Young Adult |
| title | Prescription Opioid Exposures Among Children and Adolescents in the United States: 2000-2015 |
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