Medical Treatment of Gastroesophageal Reflux Disease
Medical treatment is effective in the majority of patients with gastroesophageal reflux disease (GERD). Lifestyle modifications are often recommended for patients with GERD, although the data supporting lifestyle recommendations are limited. Antacids are often used to treat the symptoms of GERD, but...
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| Veröffentlicht in: | World journal of surgery 2017-07, Vol.41 (7), p.1678-1684 |
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| container_title | World journal of surgery |
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| creator | Kroch, Daniel A. Madanick, Ryan D. |
| description | Medical treatment is effective in the majority of patients with gastroesophageal reflux disease (GERD). Lifestyle modifications are often recommended for patients with GERD, although the data supporting lifestyle recommendations are limited. Antacids are often used to treat the symptoms of GERD, but their effect is short-lived. H2-receptor antagonists and proton-pump inhibitors provide more effective options for remission of GERD symptoms and healing of esophagitis. Prokinetic medications (e.g., metoclopramide) have not been proven to help in the control of symptoms. Baclofen, which inhibits transient lower esophageal sphincter relaxations, provide an additional option for patients with persistent symptoms related to GERD; however its use is limited by side effects. Long-term medical therapy for GERD should be tailored to each patient to provide symptomatic control and maintain esophageal mucosal healing. |
| doi_str_mv | 10.1007/s00268-017-3954-2 |
| format | Article |
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Lifestyle modifications are often recommended for patients with GERD, although the data supporting lifestyle recommendations are limited. Antacids are often used to treat the symptoms of GERD, but their effect is short-lived. H2-receptor antagonists and proton-pump inhibitors provide more effective options for remission of GERD symptoms and healing of esophagitis. Prokinetic medications (e.g., metoclopramide) have not been proven to help in the control of symptoms. Baclofen, which inhibits transient lower esophageal sphincter relaxations, provide an additional option for patients with persistent symptoms related to GERD; however its use is limited by side effects. Long-term medical therapy for GERD should be tailored to each patient to provide symptomatic control and maintain esophageal mucosal healing.</description><identifier>ISSN: 0364-2313</identifier><identifier>EISSN: 1432-2323</identifier><identifier>DOI: 10.1007/s00268-017-3954-2</identifier><identifier>PMID: 28321555</identifier><language>eng</language><publisher>Cham: Springer International Publishing</publisher><subject>Abdominal Surgery ; Alginates - therapeutic use ; Antacids ; Antacids - therapeutic use ; Baclofen ; Cardiac Surgery ; Eosinophilic Esophagitis ; Esophageal Acid Exposure ; Esophageal sphincter ; Esophagitis ; Esophagus ; Gastroesophageal reflux ; Gastroesophageal Reflux - drug therapy ; General Surgery ; GERD Symptom ; Glucuronic Acid - therapeutic use ; Healing ; Health services ; Hexuronic Acids - therapeutic use ; Histamine H2 Antagonists - therapeutic use ; Humans ; Life Style ; Medical treatment ; Medicine ; Medicine & Public Health ; Metoclopramide ; Mucosa ; Patients ; Proton pump inhibitors ; Proton Pump Inhibitors - therapeutic use ; Remission ; Side effects ; Sphincter ; Surgery ; Surgical Symposium Contribution ; Thoracic Surgery ; Vascular Surgery</subject><ispartof>World journal of surgery, 2017-07, Vol.41 (7), p.1678-1684</ispartof><rights>Société Internationale de Chirurgie 2017</rights><rights>2017 The Author(s) under exclusive licence to Société Internationale de Chirurgie</rights><rights>World Journal of Surgery is a copyright of Springer, 2017.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4227-769e64cee93b293fc00f52b080e0984bb9f257f38e31eac59876782059308c8a3</citedby><cites>FETCH-LOGICAL-c4227-769e64cee93b293fc00f52b080e0984bb9f257f38e31eac59876782059308c8a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00268-017-3954-2$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00268-017-3954-2$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,41464,42533,45550,45551,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28321555$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kroch, Daniel A.</creatorcontrib><creatorcontrib>Madanick, Ryan D.</creatorcontrib><title>Medical Treatment of Gastroesophageal Reflux Disease</title><title>World journal of surgery</title><addtitle>World J Surg</addtitle><addtitle>World J Surg</addtitle><description>Medical treatment is effective in the majority of patients with gastroesophageal reflux disease (GERD). Lifestyle modifications are often recommended for patients with GERD, although the data supporting lifestyle recommendations are limited. Antacids are often used to treat the symptoms of GERD, but their effect is short-lived. H2-receptor antagonists and proton-pump inhibitors provide more effective options for remission of GERD symptoms and healing of esophagitis. Prokinetic medications (e.g., metoclopramide) have not been proven to help in the control of symptoms. Baclofen, which inhibits transient lower esophageal sphincter relaxations, provide an additional option for patients with persistent symptoms related to GERD; however its use is limited by side effects. Long-term medical therapy for GERD should be tailored to each patient to provide symptomatic control and maintain esophageal mucosal healing.</description><subject>Abdominal Surgery</subject><subject>Alginates - therapeutic use</subject><subject>Antacids</subject><subject>Antacids - therapeutic use</subject><subject>Baclofen</subject><subject>Cardiac Surgery</subject><subject>Eosinophilic Esophagitis</subject><subject>Esophageal Acid Exposure</subject><subject>Esophageal sphincter</subject><subject>Esophagitis</subject><subject>Esophagus</subject><subject>Gastroesophageal reflux</subject><subject>Gastroesophageal Reflux - drug therapy</subject><subject>General Surgery</subject><subject>GERD Symptom</subject><subject>Glucuronic Acid - therapeutic use</subject><subject>Healing</subject><subject>Health services</subject><subject>Hexuronic Acids - therapeutic use</subject><subject>Histamine H2 Antagonists - therapeutic use</subject><subject>Humans</subject><subject>Life Style</subject><subject>Medical treatment</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Metoclopramide</subject><subject>Mucosa</subject><subject>Patients</subject><subject>Proton pump inhibitors</subject><subject>Proton Pump Inhibitors - therapeutic use</subject><subject>Remission</subject><subject>Side effects</subject><subject>Sphincter</subject><subject>Surgery</subject><subject>Surgical Symposium Contribution</subject><subject>Thoracic Surgery</subject><subject>Vascular Surgery</subject><issn>0364-2313</issn><issn>1432-2323</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNqFkEtLxDAUhYMoOj5-gBsZcOOmepPbvJa-HyiCjrgMab3VSmc6JlPUf2-GqoggrgLJdw4nH2ObHHY5gN6LAEKZDLjO0Mo8EwtswHMUmUCBi2wAqNIlclxhqzE-QwIVqGW2IgwKLqUcsPyKHurSN8NRID8b02Q2bKvhqY-z0FJsp0_-kdLrDVVN9zY8qiP5SOtsqfJNpI3Pc43dnRyPDs-yy-vT88P9y6zMhdCZVpZUXhJZLITFqgSopCjAAIE1eVHYSkhdoSHk5EtpjVbaCJAWwZTG4xrb6XunoX3pKM7cuI4lNY2fUNtFx422Kv2IY0K3f6HPbRcmaZ3jFhRKIyUkivdUGdoYA1VuGuqxD--Og5srdb1Sl0y5uVInUmbrs7krxvTwnfhymADbA691Q-__N7r7i9uDEzCIOmVFn40pNnmk8GP2n4s-AKEkjxU</recordid><startdate>201707</startdate><enddate>201707</enddate><creator>Kroch, Daniel A.</creator><creator>Madanick, Ryan D.</creator><general>Springer International Publishing</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QO</scope><scope>7T5</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FD</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>H94</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>P64</scope><scope>PHGZM</scope><scope>PHGZT</scope><scope>PJZUB</scope><scope>PKEHL</scope><scope>PPXIY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>201707</creationdate><title>Medical Treatment of Gastroesophageal Reflux Disease</title><author>Kroch, Daniel A. ; Madanick, Ryan D.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4227-769e64cee93b293fc00f52b080e0984bb9f257f38e31eac59876782059308c8a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Abdominal Surgery</topic><topic>Alginates - therapeutic use</topic><topic>Antacids</topic><topic>Antacids - therapeutic use</topic><topic>Baclofen</topic><topic>Cardiac Surgery</topic><topic>Eosinophilic Esophagitis</topic><topic>Esophageal Acid Exposure</topic><topic>Esophageal sphincter</topic><topic>Esophagitis</topic><topic>Esophagus</topic><topic>Gastroesophageal reflux</topic><topic>Gastroesophageal Reflux - drug therapy</topic><topic>General Surgery</topic><topic>GERD Symptom</topic><topic>Glucuronic Acid - therapeutic use</topic><topic>Healing</topic><topic>Health services</topic><topic>Hexuronic Acids - therapeutic use</topic><topic>Histamine H2 Antagonists - therapeutic use</topic><topic>Humans</topic><topic>Life Style</topic><topic>Medical treatment</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Metoclopramide</topic><topic>Mucosa</topic><topic>Patients</topic><topic>Proton pump inhibitors</topic><topic>Proton Pump Inhibitors - therapeutic use</topic><topic>Remission</topic><topic>Side effects</topic><topic>Sphincter</topic><topic>Surgery</topic><topic>Surgical Symposium Contribution</topic><topic>Thoracic Surgery</topic><topic>Vascular Surgery</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kroch, Daniel A.</creatorcontrib><creatorcontrib>Madanick, Ryan D.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Biotechnology Research Abstracts</collection><collection>Immunology Abstracts</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest Central (New)</collection><collection>ProQuest One Academic (New)</collection><collection>ProQuest Health & Medical Research Collection</collection><collection>ProQuest One Academic Middle East (New)</collection><collection>ProQuest One Health & Nursing</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>World journal of surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kroch, Daniel A.</au><au>Madanick, Ryan D.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Medical Treatment of Gastroesophageal Reflux Disease</atitle><jtitle>World journal of surgery</jtitle><stitle>World J Surg</stitle><addtitle>World J Surg</addtitle><date>2017-07</date><risdate>2017</risdate><volume>41</volume><issue>7</issue><spage>1678</spage><epage>1684</epage><pages>1678-1684</pages><issn>0364-2313</issn><eissn>1432-2323</eissn><abstract>Medical treatment is effective in the majority of patients with gastroesophageal reflux disease (GERD). Lifestyle modifications are often recommended for patients with GERD, although the data supporting lifestyle recommendations are limited. Antacids are often used to treat the symptoms of GERD, but their effect is short-lived. H2-receptor antagonists and proton-pump inhibitors provide more effective options for remission of GERD symptoms and healing of esophagitis. Prokinetic medications (e.g., metoclopramide) have not been proven to help in the control of symptoms. Baclofen, which inhibits transient lower esophageal sphincter relaxations, provide an additional option for patients with persistent symptoms related to GERD; however its use is limited by side effects. Long-term medical therapy for GERD should be tailored to each patient to provide symptomatic control and maintain esophageal mucosal healing.</abstract><cop>Cham</cop><pub>Springer International Publishing</pub><pmid>28321555</pmid><doi>10.1007/s00268-017-3954-2</doi><tpages>7</tpages></addata></record> |
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| subjects | Abdominal Surgery Alginates - therapeutic use Antacids Antacids - therapeutic use Baclofen Cardiac Surgery Eosinophilic Esophagitis Esophageal Acid Exposure Esophageal sphincter Esophagitis Esophagus Gastroesophageal reflux Gastroesophageal Reflux - drug therapy General Surgery GERD Symptom Glucuronic Acid - therapeutic use Healing Health services Hexuronic Acids - therapeutic use Histamine H2 Antagonists - therapeutic use Humans Life Style Medical treatment Medicine Medicine & Public Health Metoclopramide Mucosa Patients Proton pump inhibitors Proton Pump Inhibitors - therapeutic use Remission Side effects Sphincter Surgery Surgical Symposium Contribution Thoracic Surgery Vascular Surgery |
| title | Medical Treatment of Gastroesophageal Reflux Disease |
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