Lead reduces messenger RNA and protein levels of cytochrome P450 aromatase and estrogen receptor β in human ovarian granulosa cells

Exposure to lead causes decreased fertility in women. In the present study, we examined the in vitro effects of lead on cytochrome p450 aromatase (p450 arom) and on estrogen receptor beta (ERbeta), two key proteins for the human ovary. Aromatase is required for the bioconversion of androgen to estra...

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Veröffentlicht in:	Biology of reproduction 2003-06, Vol.68 (6), p.1982-1988
Hauptverfasser:	TAUPEAU, Crystel, POUPON, Joël, TRETON, Dominique, BROSSE, Aurélie, RICHARD, Yolande, MACHELON, Véronique
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aromatase - biosynthesis Biological and medical sciences Blotting, Western Cells, Cultured Chemical and industrial products toxicology. Toxic occupational diseases Depression, Chemical DNA Primers DNA, Complementary - biosynthesis DNA, Complementary - genetics Estrogen Receptor beta Ethidium Female Fertilization in Vitro Fluorescent Dyes Granulosa Cells - drug effects Granulosa Cells - metabolism Humans Lead - toxicity Medical sciences Metals and various inorganic compounds Ovary - cytology Ovary - drug effects Ovary - metabolism Receptors, Estrogen - biosynthesis Reverse Transcriptase Polymerase Chain Reaction RNA, Messenger - biosynthesis Toxicology
Online-Zugang:	Volltext
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