Role of NF-κB and Akt/PI3K in the resistance of pancreatic carcinoma cell lines against gemcitabine-induced cell death

Pancreatic cancer is resistant to almost all cytotoxic drugs. Currently, gemcitabine appears to be the only clinically active drug but, because of pre-existing or acquired chemoresistance of most of the tumor cells, it failed to significantly improve the outcome of pancreatic carcinoma patients. The...

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Veröffentlicht in:	Oncogene 2003-05, Vol.22 (21), p.3243-3251
Hauptverfasser:	Arlt, Alexander, Gehrz, Andre, Müerköster, Susanne, Vorndamm, Jens, Kruse, Marie-Luise, Fölsch, Ulrich R, Schäfer, Heiner
Format:	Artikel
Sprache:	eng
Schlagworte:	1-Phosphatidylinositol 3-kinase AKT protein Apoptosis Biological and medical sciences Cell Biology Cell death Chemoresistance Cytotoxicity Fundamental and applied biological sciences. Psychology Gemcitabine Human Genetics Internal Medicine Medicine Medicine & Public Health Molecular and cellular biology NF-κB protein Oncology original-paper Pancreatic cancer Pancreatic carcinoma Sulfasalazine Tumor cell lines Tumor cells
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