Distinct expression of NK2 homeobox 1 (NKX2‐1) and goblet cell hyperplasia in nasal polyps with different endotypes

Background Decreased expression of airway epithelial‐specific transcription factor NK2 homeobox 1 (NKX2‐1) was associated with allergic inflammation in asthma patients. However, the expression and role of NKX2‐1 in nasal polyps (NPs) with different endotypes were undefined yet. Methods We examined t...

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Veröffentlicht in:	International forum of allergy & rhinology 2017-07, Vol.7 (7), p.690-698
Hauptverfasser:	Du, Jintao, Ba, Luo, Li, Bo, Liu, Feng, Hu, Xianting, Zhang, Jie, Liu, Yafeng, Xian, Junming, Liu, Sixi, Li, Huabin
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Asthma CCL17 protein Chemokine CCL17 - metabolism chronic rhinosinusitis cytokine Cytokines Diagnosis, Differential Enzyme-linked immunosorbent assay Eosinophilia ETS protein Female Forkhead protein FoxA2 Gene Expression Regulation Goblet cells Goblet Cells - metabolism Goblet Cells - pathology Hepatocyte Nuclear Factor 3-beta - genetics Hepatocyte Nuclear Factor 3-beta - metabolism Homeobox Humans Hyperplasia Hypersensitivity Immunohistochemistry Inflammation Interleukin 13 Interleukin 4 Interleukin 5 Interleukin-4 - metabolism Interleukin-5 - metabolism Leukocytes (eosinophilic) Male MUC5AC Mucin Mucin 5AC - metabolism nasal polyps Nasal Polyps - diagnosis Nasal Polyps - genetics NKX2‐1 Polymerase chain reaction Polyps Proto-Oncogene Proteins c-ets - genetics Proto-Oncogene Proteins c-ets - metabolism Respiratory tract Rhinosinusitis Thyroid Nuclear Factor 1 - genetics Thyroid Nuclear Factor 1 - metabolism Thyroid transcription factor 1 Transcription factors Young Adult
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