Distinct expression of NK2 homeobox 1 (NKX2‐1) and goblet cell hyperplasia in nasal polyps with different endotypes
Background Decreased expression of airway epithelial‐specific transcription factor NK2 homeobox 1 (NKX2‐1) was associated with allergic inflammation in asthma patients. However, the expression and role of NKX2‐1 in nasal polyps (NPs) with different endotypes were undefined yet. Methods We examined t...
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| Veröffentlicht in: | International forum of allergy & rhinology 2017-07, Vol.7 (7), p.690-698 |
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| creator | Du, Jintao Ba, Luo Li, Bo Liu, Feng Hu, Xianting Zhang, Jie Liu, Yafeng Xian, Junming Liu, Sixi Li, Huabin |
| description | Background
Decreased expression of airway epithelial‐specific transcription factor NK2 homeobox 1 (NKX2‐1) was associated with allergic inflammation in asthma patients. However, the expression and role of NKX2‐1 in nasal polyps (NPs) with different endotypes were undefined yet.
Methods
We examined the expression of key cytokines (interleukin [IL]‐4 IL‐5, IL‐13, and IL‐17A, etc.) and NKX2‐1 in NPs with different endotypes and control tissues by immunohistochemistry staining, qualitative polymerase chain reaction (qPCR), enzyme‐linked immunosorbent assay (ELISA), and Western blot analysis.
Results
We found 23% of chronic rhinosinusitis (CRS) with NP (CRSwNP) patients had IL‐5+ eosinophilic NPs, 40.7% of NPs were key cytokines negative NPs (KCN NPs) with less eosinophil accumulation. The expression of NKX2‐1 in IL‐5+ NPs was significantly lower than KCN NPs and normal controls (p < 0.05). The expression of mucin 5AC (MUC5AC) and MUC5B, as well as goblet cells hyperplasia, were significantly elevated in IL‐5+ NPs, which correlated with the decreased expression of NKX2‐1 (p < 0.05). Moreover, “SAM pointed domain containing ETS transcription factor” (SPDEF) was significantly elevated, while expression of Forkhead Box A2 (FoxA2) was significantly decreased in IL‐5+ NPs (p < 0.05). The expression of chemokine (C‐C motif) ligand 17 (CCL17) and IL‐4 was significantly increased in IL‐5+ NPs, which was associated with eosinophil accumulation(p < 0.05).
Conclusion
The downregulation of NKX2‐1 in IL‐5+ NPs may be associated with tissue eosinophilia and goblet cells hyperplasia. |
| doi_str_mv | 10.1002/alr.21932 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1879192756</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1915933811</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3532-2727e9bb388066cfe63c39c5dfd095b400a3fad610b4711ab11e4994ffcd8fc93</originalsourceid><addsrcrecordid>eNp10c9KHTEUBvBQKlWsi75ACXSji6s5yfzLUrS1xYtCaaG7kMmc9EZyk2kyg95dH6HP6JM09loXgtkkix9fDucj5B2wY2CMn2ifjjlIwV-RPc4qvmhkV71-erfNLjnI-YaVU0NdQ_uG7PJOQAfQ7ZH53OXJBTNRvBsT5uxioNHSq0tOV3GNsY93FOjh1eUPfv_7DxxRHQb6M_YeJ2rQe7rajJhGr7PT1AUadNaejtFvxkxv3bSig7MWE4byRRjiVHh-S3as9hkPHu998v3Tx29nnxfL64svZ6fLhRG14Ave8hZl34uuY01jLDbCCGnqwQ5M1n3FmBZWDw2wvmoBdA-AlZSVtWborJFinxxuc8cUf82YJ7V2-WFqHTDOWUHXSpC8rZtCPzyjN3FOoUynQEIthSgLK-poq0yKOSe0akxurdNGAVMPdahSh_pXR7HvHxPnfo3Dk_y__AJOtuDWedy8nKROl1-3kX8BI3OT4A</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1915933811</pqid></control><display><type>article</type><title>Distinct expression of NK2 homeobox 1 (NKX2‐1) and goblet cell hyperplasia in nasal polyps with different endotypes</title><source>MEDLINE</source><source>Wiley Journals</source><creator>Du, Jintao ; Ba, Luo ; Li, Bo ; Liu, Feng ; Hu, Xianting ; Zhang, Jie ; Liu, Yafeng ; Xian, Junming ; Liu, Sixi ; Li, Huabin</creator><creatorcontrib>Du, Jintao ; Ba, Luo ; Li, Bo ; Liu, Feng ; Hu, Xianting ; Zhang, Jie ; Liu, Yafeng ; Xian, Junming ; Liu, Sixi ; Li, Huabin</creatorcontrib><description>Background
Decreased expression of airway epithelial‐specific transcription factor NK2 homeobox 1 (NKX2‐1) was associated with allergic inflammation in asthma patients. However, the expression and role of NKX2‐1 in nasal polyps (NPs) with different endotypes were undefined yet.
Methods
We examined the expression of key cytokines (interleukin [IL]‐4 IL‐5, IL‐13, and IL‐17A, etc.) and NKX2‐1 in NPs with different endotypes and control tissues by immunohistochemistry staining, qualitative polymerase chain reaction (qPCR), enzyme‐linked immunosorbent assay (ELISA), and Western blot analysis.
Results
We found 23% of chronic rhinosinusitis (CRS) with NP (CRSwNP) patients had IL‐5+ eosinophilic NPs, 40.7% of NPs were key cytokines negative NPs (KCN NPs) with less eosinophil accumulation. The expression of NKX2‐1 in IL‐5+ NPs was significantly lower than KCN NPs and normal controls (p < 0.05). The expression of mucin 5AC (MUC5AC) and MUC5B, as well as goblet cells hyperplasia, were significantly elevated in IL‐5+ NPs, which correlated with the decreased expression of NKX2‐1 (p < 0.05). Moreover, “SAM pointed domain containing ETS transcription factor” (SPDEF) was significantly elevated, while expression of Forkhead Box A2 (FoxA2) was significantly decreased in IL‐5+ NPs (p < 0.05). The expression of chemokine (C‐C motif) ligand 17 (CCL17) and IL‐4 was significantly increased in IL‐5+ NPs, which was associated with eosinophil accumulation(p < 0.05).
Conclusion
The downregulation of NKX2‐1 in IL‐5+ NPs may be associated with tissue eosinophilia and goblet cells hyperplasia.</description><identifier>ISSN: 2042-6976</identifier><identifier>EISSN: 2042-6984</identifier><identifier>DOI: 10.1002/alr.21932</identifier><identifier>PMID: 28318118</identifier><language>eng</language><publisher>United States: Wiley Subscription Services, Inc</publisher><subject>Adult ; Asthma ; CCL17 protein ; Chemokine CCL17 - metabolism ; chronic rhinosinusitis ; cytokine ; Cytokines ; Diagnosis, Differential ; Enzyme-linked immunosorbent assay ; Eosinophilia ; ETS protein ; Female ; Forkhead protein ; FoxA2 ; Gene Expression Regulation ; Goblet cells ; Goblet Cells - metabolism ; Goblet Cells - pathology ; Hepatocyte Nuclear Factor 3-beta - genetics ; Hepatocyte Nuclear Factor 3-beta - metabolism ; Homeobox ; Humans ; Hyperplasia ; Hypersensitivity ; Immunohistochemistry ; Inflammation ; Interleukin 13 ; Interleukin 4 ; Interleukin 5 ; Interleukin-4 - metabolism ; Interleukin-5 - metabolism ; Leukocytes (eosinophilic) ; Male ; MUC5AC ; Mucin ; Mucin 5AC - metabolism ; nasal polyps ; Nasal Polyps - diagnosis ; Nasal Polyps - genetics ; NKX2‐1 ; Polymerase chain reaction ; Polyps ; Proto-Oncogene Proteins c-ets - genetics ; Proto-Oncogene Proteins c-ets - metabolism ; Respiratory tract ; Rhinosinusitis ; Thyroid Nuclear Factor 1 - genetics ; Thyroid Nuclear Factor 1 - metabolism ; Thyroid transcription factor 1 ; Transcription factors ; Young Adult</subject><ispartof>International forum of allergy & rhinology, 2017-07, Vol.7 (7), p.690-698</ispartof><rights>2017 ARS‐AAOA, LLC</rights><rights>2017 ARS-AAOA, LLC.</rights><rights>2017 ARS-AAOA, LLC</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3532-2727e9bb388066cfe63c39c5dfd095b400a3fad610b4711ab11e4994ffcd8fc93</citedby><cites>FETCH-LOGICAL-c3532-2727e9bb388066cfe63c39c5dfd095b400a3fad610b4711ab11e4994ffcd8fc93</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Falr.21932$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Falr.21932$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,777,781,1412,27905,27906,45555,45556</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28318118$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Du, Jintao</creatorcontrib><creatorcontrib>Ba, Luo</creatorcontrib><creatorcontrib>Li, Bo</creatorcontrib><creatorcontrib>Liu, Feng</creatorcontrib><creatorcontrib>Hu, Xianting</creatorcontrib><creatorcontrib>Zhang, Jie</creatorcontrib><creatorcontrib>Liu, Yafeng</creatorcontrib><creatorcontrib>Xian, Junming</creatorcontrib><creatorcontrib>Liu, Sixi</creatorcontrib><creatorcontrib>Li, Huabin</creatorcontrib><title>Distinct expression of NK2 homeobox 1 (NKX2‐1) and goblet cell hyperplasia in nasal polyps with different endotypes</title><title>International forum of allergy & rhinology</title><addtitle>Int Forum Allergy Rhinol</addtitle><description>Background
Decreased expression of airway epithelial‐specific transcription factor NK2 homeobox 1 (NKX2‐1) was associated with allergic inflammation in asthma patients. However, the expression and role of NKX2‐1 in nasal polyps (NPs) with different endotypes were undefined yet.
Methods
We examined the expression of key cytokines (interleukin [IL]‐4 IL‐5, IL‐13, and IL‐17A, etc.) and NKX2‐1 in NPs with different endotypes and control tissues by immunohistochemistry staining, qualitative polymerase chain reaction (qPCR), enzyme‐linked immunosorbent assay (ELISA), and Western blot analysis.
Results
We found 23% of chronic rhinosinusitis (CRS) with NP (CRSwNP) patients had IL‐5+ eosinophilic NPs, 40.7% of NPs were key cytokines negative NPs (KCN NPs) with less eosinophil accumulation. The expression of NKX2‐1 in IL‐5+ NPs was significantly lower than KCN NPs and normal controls (p < 0.05). The expression of mucin 5AC (MUC5AC) and MUC5B, as well as goblet cells hyperplasia, were significantly elevated in IL‐5+ NPs, which correlated with the decreased expression of NKX2‐1 (p < 0.05). Moreover, “SAM pointed domain containing ETS transcription factor” (SPDEF) was significantly elevated, while expression of Forkhead Box A2 (FoxA2) was significantly decreased in IL‐5+ NPs (p < 0.05). The expression of chemokine (C‐C motif) ligand 17 (CCL17) and IL‐4 was significantly increased in IL‐5+ NPs, which was associated with eosinophil accumulation(p < 0.05).
Conclusion
The downregulation of NKX2‐1 in IL‐5+ NPs may be associated with tissue eosinophilia and goblet cells hyperplasia.</description><subject>Adult</subject><subject>Asthma</subject><subject>CCL17 protein</subject><subject>Chemokine CCL17 - metabolism</subject><subject>chronic rhinosinusitis</subject><subject>cytokine</subject><subject>Cytokines</subject><subject>Diagnosis, Differential</subject><subject>Enzyme-linked immunosorbent assay</subject><subject>Eosinophilia</subject><subject>ETS protein</subject><subject>Female</subject><subject>Forkhead protein</subject><subject>FoxA2</subject><subject>Gene Expression Regulation</subject><subject>Goblet cells</subject><subject>Goblet Cells - metabolism</subject><subject>Goblet Cells - pathology</subject><subject>Hepatocyte Nuclear Factor 3-beta - genetics</subject><subject>Hepatocyte Nuclear Factor 3-beta - metabolism</subject><subject>Homeobox</subject><subject>Humans</subject><subject>Hyperplasia</subject><subject>Hypersensitivity</subject><subject>Immunohistochemistry</subject><subject>Inflammation</subject><subject>Interleukin 13</subject><subject>Interleukin 4</subject><subject>Interleukin 5</subject><subject>Interleukin-4 - metabolism</subject><subject>Interleukin-5 - metabolism</subject><subject>Leukocytes (eosinophilic)</subject><subject>Male</subject><subject>MUC5AC</subject><subject>Mucin</subject><subject>Mucin 5AC - metabolism</subject><subject>nasal polyps</subject><subject>Nasal Polyps - diagnosis</subject><subject>Nasal Polyps - genetics</subject><subject>NKX2‐1</subject><subject>Polymerase chain reaction</subject><subject>Polyps</subject><subject>Proto-Oncogene Proteins c-ets - genetics</subject><subject>Proto-Oncogene Proteins c-ets - metabolism</subject><subject>Respiratory tract</subject><subject>Rhinosinusitis</subject><subject>Thyroid Nuclear Factor 1 - genetics</subject><subject>Thyroid Nuclear Factor 1 - metabolism</subject><subject>Thyroid transcription factor 1</subject><subject>Transcription factors</subject><subject>Young Adult</subject><issn>2042-6976</issn><issn>2042-6984</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp10c9KHTEUBvBQKlWsi75ACXSji6s5yfzLUrS1xYtCaaG7kMmc9EZyk2kyg95dH6HP6JM09loXgtkkix9fDucj5B2wY2CMn2ifjjlIwV-RPc4qvmhkV71-erfNLjnI-YaVU0NdQ_uG7PJOQAfQ7ZH53OXJBTNRvBsT5uxioNHSq0tOV3GNsY93FOjh1eUPfv_7DxxRHQb6M_YeJ2rQe7rajJhGr7PT1AUadNaejtFvxkxv3bSig7MWE4byRRjiVHh-S3as9hkPHu998v3Tx29nnxfL64svZ6fLhRG14Ave8hZl34uuY01jLDbCCGnqwQ5M1n3FmBZWDw2wvmoBdA-AlZSVtWborJFinxxuc8cUf82YJ7V2-WFqHTDOWUHXSpC8rZtCPzyjN3FOoUynQEIthSgLK-poq0yKOSe0akxurdNGAVMPdahSh_pXR7HvHxPnfo3Dk_y__AJOtuDWedy8nKROl1-3kX8BI3OT4A</recordid><startdate>201707</startdate><enddate>201707</enddate><creator>Du, Jintao</creator><creator>Ba, Luo</creator><creator>Li, Bo</creator><creator>Liu, Feng</creator><creator>Hu, Xianting</creator><creator>Zhang, Jie</creator><creator>Liu, Yafeng</creator><creator>Xian, Junming</creator><creator>Liu, Sixi</creator><creator>Li, Huabin</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>201707</creationdate><title>Distinct expression of NK2 homeobox 1 (NKX2‐1) and goblet cell hyperplasia in nasal polyps with different endotypes</title><author>Du, Jintao ; Ba, Luo ; Li, Bo ; Liu, Feng ; Hu, Xianting ; Zhang, Jie ; Liu, Yafeng ; Xian, Junming ; Liu, Sixi ; Li, Huabin</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3532-2727e9bb388066cfe63c39c5dfd095b400a3fad610b4711ab11e4994ffcd8fc93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Adult</topic><topic>Asthma</topic><topic>CCL17 protein</topic><topic>Chemokine CCL17 - metabolism</topic><topic>chronic rhinosinusitis</topic><topic>cytokine</topic><topic>Cytokines</topic><topic>Diagnosis, Differential</topic><topic>Enzyme-linked immunosorbent assay</topic><topic>Eosinophilia</topic><topic>ETS protein</topic><topic>Female</topic><topic>Forkhead protein</topic><topic>FoxA2</topic><topic>Gene Expression Regulation</topic><topic>Goblet cells</topic><topic>Goblet Cells - metabolism</topic><topic>Goblet Cells - pathology</topic><topic>Hepatocyte Nuclear Factor 3-beta - genetics</topic><topic>Hepatocyte Nuclear Factor 3-beta - metabolism</topic><topic>Homeobox</topic><topic>Humans</topic><topic>Hyperplasia</topic><topic>Hypersensitivity</topic><topic>Immunohistochemistry</topic><topic>Inflammation</topic><topic>Interleukin 13</topic><topic>Interleukin 4</topic><topic>Interleukin 5</topic><topic>Interleukin-4 - metabolism</topic><topic>Interleukin-5 - metabolism</topic><topic>Leukocytes (eosinophilic)</topic><topic>Male</topic><topic>MUC5AC</topic><topic>Mucin</topic><topic>Mucin 5AC - metabolism</topic><topic>nasal polyps</topic><topic>Nasal Polyps - diagnosis</topic><topic>Nasal Polyps - genetics</topic><topic>NKX2‐1</topic><topic>Polymerase chain reaction</topic><topic>Polyps</topic><topic>Proto-Oncogene Proteins c-ets - genetics</topic><topic>Proto-Oncogene Proteins c-ets - metabolism</topic><topic>Respiratory tract</topic><topic>Rhinosinusitis</topic><topic>Thyroid Nuclear Factor 1 - genetics</topic><topic>Thyroid Nuclear Factor 1 - metabolism</topic><topic>Thyroid transcription factor 1</topic><topic>Transcription factors</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Du, Jintao</creatorcontrib><creatorcontrib>Ba, Luo</creatorcontrib><creatorcontrib>Li, Bo</creatorcontrib><creatorcontrib>Liu, Feng</creatorcontrib><creatorcontrib>Hu, Xianting</creatorcontrib><creatorcontrib>Zhang, Jie</creatorcontrib><creatorcontrib>Liu, Yafeng</creatorcontrib><creatorcontrib>Xian, Junming</creatorcontrib><creatorcontrib>Liu, Sixi</creatorcontrib><creatorcontrib>Li, Huabin</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>International forum of allergy & rhinology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Du, Jintao</au><au>Ba, Luo</au><au>Li, Bo</au><au>Liu, Feng</au><au>Hu, Xianting</au><au>Zhang, Jie</au><au>Liu, Yafeng</au><au>Xian, Junming</au><au>Liu, Sixi</au><au>Li, Huabin</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Distinct expression of NK2 homeobox 1 (NKX2‐1) and goblet cell hyperplasia in nasal polyps with different endotypes</atitle><jtitle>International forum of allergy & rhinology</jtitle><addtitle>Int Forum Allergy Rhinol</addtitle><date>2017-07</date><risdate>2017</risdate><volume>7</volume><issue>7</issue><spage>690</spage><epage>698</epage><pages>690-698</pages><issn>2042-6976</issn><eissn>2042-6984</eissn><abstract>Background
Decreased expression of airway epithelial‐specific transcription factor NK2 homeobox 1 (NKX2‐1) was associated with allergic inflammation in asthma patients. However, the expression and role of NKX2‐1 in nasal polyps (NPs) with different endotypes were undefined yet.
Methods
We examined the expression of key cytokines (interleukin [IL]‐4 IL‐5, IL‐13, and IL‐17A, etc.) and NKX2‐1 in NPs with different endotypes and control tissues by immunohistochemistry staining, qualitative polymerase chain reaction (qPCR), enzyme‐linked immunosorbent assay (ELISA), and Western blot analysis.
Results
We found 23% of chronic rhinosinusitis (CRS) with NP (CRSwNP) patients had IL‐5+ eosinophilic NPs, 40.7% of NPs were key cytokines negative NPs (KCN NPs) with less eosinophil accumulation. The expression of NKX2‐1 in IL‐5+ NPs was significantly lower than KCN NPs and normal controls (p < 0.05). The expression of mucin 5AC (MUC5AC) and MUC5B, as well as goblet cells hyperplasia, were significantly elevated in IL‐5+ NPs, which correlated with the decreased expression of NKX2‐1 (p < 0.05). Moreover, “SAM pointed domain containing ETS transcription factor” (SPDEF) was significantly elevated, while expression of Forkhead Box A2 (FoxA2) was significantly decreased in IL‐5+ NPs (p < 0.05). The expression of chemokine (C‐C motif) ligand 17 (CCL17) and IL‐4 was significantly increased in IL‐5+ NPs, which was associated with eosinophil accumulation(p < 0.05).
Conclusion
The downregulation of NKX2‐1 in IL‐5+ NPs may be associated with tissue eosinophilia and goblet cells hyperplasia.</abstract><cop>United States</cop><pub>Wiley Subscription Services, Inc</pub><pmid>28318118</pmid><doi>10.1002/alr.21932</doi><tpages>9</tpages></addata></record> |
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| ispartof | International forum of allergy & rhinology, 2017-07, Vol.7 (7), p.690-698 |
| issn | 2042-6976 2042-6984 |
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| subjects | Adult Asthma CCL17 protein Chemokine CCL17 - metabolism chronic rhinosinusitis cytokine Cytokines Diagnosis, Differential Enzyme-linked immunosorbent assay Eosinophilia ETS protein Female Forkhead protein FoxA2 Gene Expression Regulation Goblet cells Goblet Cells - metabolism Goblet Cells - pathology Hepatocyte Nuclear Factor 3-beta - genetics Hepatocyte Nuclear Factor 3-beta - metabolism Homeobox Humans Hyperplasia Hypersensitivity Immunohistochemistry Inflammation Interleukin 13 Interleukin 4 Interleukin 5 Interleukin-4 - metabolism Interleukin-5 - metabolism Leukocytes (eosinophilic) Male MUC5AC Mucin Mucin 5AC - metabolism nasal polyps Nasal Polyps - diagnosis Nasal Polyps - genetics NKX2‐1 Polymerase chain reaction Polyps Proto-Oncogene Proteins c-ets - genetics Proto-Oncogene Proteins c-ets - metabolism Respiratory tract Rhinosinusitis Thyroid Nuclear Factor 1 - genetics Thyroid Nuclear Factor 1 - metabolism Thyroid transcription factor 1 Transcription factors Young Adult |
| title | Distinct expression of NK2 homeobox 1 (NKX2‐1) and goblet cell hyperplasia in nasal polyps with different endotypes |
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