Fun cube based brain gym cognitive function assessment system

Abstract The aim of this study is to design and develop a fun cube (FC) based brain gym (BG) cognitive function assessment system using the wireless sensor network and multimedia technologies. The system comprised (1) interaction devices, FCs and a workstation used as interactive tools for collectin...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Computers in biology and medicine 2017-05, Vol.84, p.1-8
Hauptverfasser: Zhang, Tao, Lin, Chung-Chih, Yu, Tsang-Chu, Sun, Jing, Hsu, Wen-Chuin, Wong, Alice May-Kuen
Format: Artikel
Sprache:eng
Schlagworte:
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page 8
container_issue
container_start_page 1
container_title Computers in biology and medicine
container_volume 84
creator Zhang, Tao
Lin, Chung-Chih
Yu, Tsang-Chu
Sun, Jing
Hsu, Wen-Chuin
Wong, Alice May-Kuen
description Abstract The aim of this study is to design and develop a fun cube (FC) based brain gym (BG) cognitive function assessment system using the wireless sensor network and multimedia technologies. The system comprised (1) interaction devices, FCs and a workstation used as interactive tools for collecting and transferring data to the server, (2) a BG information management system responsible for managing the cognitive games and storing test results, and (3) a feedback system used for conducting the analysis of cognitive functions to assist caregivers in screening high risk groups with mild cognitive impairment. Three kinds of experiments were performed to evaluate the developed FC-based BG cognitive function assessment system. The experimental results showed that the Pearson correlation coefficient between the system's evaluation outcomes and the traditional Montreal Cognitive Assessment scores was 0.83. The average Technology Acceptance Model 2 score was close to six for 31 elderly subjects. Most subjects considered that the brain games are interesting and the FC human-machine interface is easy to learn and operate. The control group and the cognitive impairment group had statistically significant difference with respect to the accuracy of and the time taken for the brain cognitive function assessment games, including Animal Naming, Color Search, Trail Making Test, Change Blindness, and Forward / Backward Digit Span.
doi_str_mv 10.1016/j.compbiomed.2017.03.003
format Article
fullrecord <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1879190776</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>1_s2_0_S0010482517300537</els_id><sourcerecordid>1879190776</sourcerecordid><originalsourceid>FETCH-LOGICAL-c510t-7b4802526001ee272098e25ec96377d996de53dc9987c564f8c06bb19c048e983</originalsourceid><addsrcrecordid>eNqNkUtr3DAURkVpaKZp_0IRdNONnauXJS1aaELSBAJdtF0LW74TNLWlqWUH5t9HZhICWXWlhc59nY8QyqBmwJrzXe3TuO9CGrGvOTBdg6gBxBuyYUbbCpSQb8kGgEElDVen5H3OOwCQIOAdOeVGMKUVbMjX6yVSv3RIuzZjT7upDZHeH0bq030Mc3hAul2in0OKtM0Zcx4xzjQf8ozjB3KybYeMH5_eM_Ln-ur35U119_PH7eX3u8orBnOlO2mAK96UhRC55mANcoXeNkLr3tqmRyV6b63RXjVyazw0XcesB2nQGnFGvhz77qf0b8E8uzFkj8PQRkxLduvRzILWTUE_v0J3aZli2a5QlmsjpWSFMkfKTynnCbduP4WxnQ6OgVsVu517UexWxQ6EK4pL6aenAUu3_j0XPjstwMURwGLkIeDksg8YPfZhQj-7PoX_mfLtVRM_hBh8O_zFA-aXm1zmDtyvNeo1aaYFlPS1eAS6xqST</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1892784441</pqid></control><display><type>article</type><title>Fun cube based brain gym cognitive function assessment system</title><source>MEDLINE</source><source>Access via ScienceDirect (Elsevier)</source><source>ProQuest Central UK/Ireland</source><creator>Zhang, Tao ; Lin, Chung-Chih ; Yu, Tsang-Chu ; Sun, Jing ; Hsu, Wen-Chuin ; Wong, Alice May-Kuen</creator><creatorcontrib>Zhang, Tao ; Lin, Chung-Chih ; Yu, Tsang-Chu ; Sun, Jing ; Hsu, Wen-Chuin ; Wong, Alice May-Kuen</creatorcontrib><description>Abstract The aim of this study is to design and develop a fun cube (FC) based brain gym (BG) cognitive function assessment system using the wireless sensor network and multimedia technologies. The system comprised (1) interaction devices, FCs and a workstation used as interactive tools for collecting and transferring data to the server, (2) a BG information management system responsible for managing the cognitive games and storing test results, and (3) a feedback system used for conducting the analysis of cognitive functions to assist caregivers in screening high risk groups with mild cognitive impairment. Three kinds of experiments were performed to evaluate the developed FC-based BG cognitive function assessment system. The experimental results showed that the Pearson correlation coefficient between the system's evaluation outcomes and the traditional Montreal Cognitive Assessment scores was 0.83. The average Technology Acceptance Model 2 score was close to six for 31 elderly subjects. Most subjects considered that the brain games are interesting and the FC human-machine interface is easy to learn and operate. The control group and the cognitive impairment group had statistically significant difference with respect to the accuracy of and the time taken for the brain cognitive function assessment games, including Animal Naming, Color Search, Trail Making Test, Change Blindness, and Forward / Backward Digit Span.</description><identifier>ISSN: 0010-4825</identifier><identifier>EISSN: 1879-0534</identifier><identifier>DOI: 10.1016/j.compbiomed.2017.03.003</identifier><identifier>PMID: 28315750</identifier><language>eng</language><publisher>United States: Elsevier Ltd</publisher><subject>Acceptance tests ; Aged ; Aged, 80 and over ; Aging ; Alzheimer's disease ; Blindness ; Brain ; Brain - physiology ; Brain gym ; Cognition &amp; reasoning ; Cognition - physiology ; Cognitive ability ; Cognitive Dysfunction - diagnosis ; Cognitive function impairment ; Color ; Computer Communication Networks ; Correlation coefficient ; Correlation coefficients ; Data base management systems ; Data transmission ; Dementia ; Feedback ; Female ; Fun cube ; Games ; Geriatrics ; Humans ; Impairment ; Information management ; Information systems ; Interactive computer systems ; Interactive systems ; Internal Medicine ; Male ; Man-machine interfaces ; Memory ; Multimedia ; Neuropsychological Tests ; Older people ; Other ; Personal computers ; Risk groups ; Sensors ; Statistical analysis ; Technology utilization ; Video Games ; Wireless communications ; Wireless sensor network ; Wireless sensor networks</subject><ispartof>Computers in biology and medicine, 2017-05, Vol.84, p.1-8</ispartof><rights>2017 Elsevier Ltd</rights><rights>Copyright © 2017 Elsevier Ltd. All rights reserved.</rights><rights>Copyright Elsevier Limited May 1, 2017</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c510t-7b4802526001ee272098e25ec96377d996de53dc9987c564f8c06bb19c048e983</citedby><cites>FETCH-LOGICAL-c510t-7b4802526001ee272098e25ec96377d996de53dc9987c564f8c06bb19c048e983</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.proquest.com/docview/1892784441?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>314,780,784,3550,27924,27925,45995,64385,64387,64389,72469</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28315750$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Zhang, Tao</creatorcontrib><creatorcontrib>Lin, Chung-Chih</creatorcontrib><creatorcontrib>Yu, Tsang-Chu</creatorcontrib><creatorcontrib>Sun, Jing</creatorcontrib><creatorcontrib>Hsu, Wen-Chuin</creatorcontrib><creatorcontrib>Wong, Alice May-Kuen</creatorcontrib><title>Fun cube based brain gym cognitive function assessment system</title><title>Computers in biology and medicine</title><addtitle>Comput Biol Med</addtitle><description>Abstract The aim of this study is to design and develop a fun cube (FC) based brain gym (BG) cognitive function assessment system using the wireless sensor network and multimedia technologies. The system comprised (1) interaction devices, FCs and a workstation used as interactive tools for collecting and transferring data to the server, (2) a BG information management system responsible for managing the cognitive games and storing test results, and (3) a feedback system used for conducting the analysis of cognitive functions to assist caregivers in screening high risk groups with mild cognitive impairment. Three kinds of experiments were performed to evaluate the developed FC-based BG cognitive function assessment system. The experimental results showed that the Pearson correlation coefficient between the system's evaluation outcomes and the traditional Montreal Cognitive Assessment scores was 0.83. The average Technology Acceptance Model 2 score was close to six for 31 elderly subjects. Most subjects considered that the brain games are interesting and the FC human-machine interface is easy to learn and operate. The control group and the cognitive impairment group had statistically significant difference with respect to the accuracy of and the time taken for the brain cognitive function assessment games, including Animal Naming, Color Search, Trail Making Test, Change Blindness, and Forward / Backward Digit Span.</description><subject>Acceptance tests</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Aging</subject><subject>Alzheimer's disease</subject><subject>Blindness</subject><subject>Brain</subject><subject>Brain - physiology</subject><subject>Brain gym</subject><subject>Cognition &amp; reasoning</subject><subject>Cognition - physiology</subject><subject>Cognitive ability</subject><subject>Cognitive Dysfunction - diagnosis</subject><subject>Cognitive function impairment</subject><subject>Color</subject><subject>Computer Communication Networks</subject><subject>Correlation coefficient</subject><subject>Correlation coefficients</subject><subject>Data base management systems</subject><subject>Data transmission</subject><subject>Dementia</subject><subject>Feedback</subject><subject>Female</subject><subject>Fun cube</subject><subject>Games</subject><subject>Geriatrics</subject><subject>Humans</subject><subject>Impairment</subject><subject>Information management</subject><subject>Information systems</subject><subject>Interactive computer systems</subject><subject>Interactive systems</subject><subject>Internal Medicine</subject><subject>Male</subject><subject>Man-machine interfaces</subject><subject>Memory</subject><subject>Multimedia</subject><subject>Neuropsychological Tests</subject><subject>Older people</subject><subject>Other</subject><subject>Personal computers</subject><subject>Risk groups</subject><subject>Sensors</subject><subject>Statistical analysis</subject><subject>Technology utilization</subject><subject>Video Games</subject><subject>Wireless communications</subject><subject>Wireless sensor network</subject><subject>Wireless sensor networks</subject><issn>0010-4825</issn><issn>1879-0534</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNqNkUtr3DAURkVpaKZp_0IRdNONnauXJS1aaELSBAJdtF0LW74TNLWlqWUH5t9HZhICWXWlhc59nY8QyqBmwJrzXe3TuO9CGrGvOTBdg6gBxBuyYUbbCpSQb8kGgEElDVen5H3OOwCQIOAdOeVGMKUVbMjX6yVSv3RIuzZjT7upDZHeH0bq030Mc3hAul2in0OKtM0Zcx4xzjQf8ozjB3KybYeMH5_eM_Ln-ur35U119_PH7eX3u8orBnOlO2mAK96UhRC55mANcoXeNkLr3tqmRyV6b63RXjVyazw0XcesB2nQGnFGvhz77qf0b8E8uzFkj8PQRkxLduvRzILWTUE_v0J3aZli2a5QlmsjpWSFMkfKTynnCbduP4WxnQ6OgVsVu517UexWxQ6EK4pL6aenAUu3_j0XPjstwMURwGLkIeDksg8YPfZhQj-7PoX_mfLtVRM_hBh8O_zFA-aXm1zmDtyvNeo1aaYFlPS1eAS6xqST</recordid><startdate>20170501</startdate><enddate>20170501</enddate><creator>Zhang, Tao</creator><creator>Lin, Chung-Chih</creator><creator>Yu, Tsang-Chu</creator><creator>Sun, Jing</creator><creator>Hsu, Wen-Chuin</creator><creator>Wong, Alice May-Kuen</creator><general>Elsevier Ltd</general><general>Elsevier Limited</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AL</scope><scope>8AO</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>HCIFZ</scope><scope>JQ2</scope><scope>K7-</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0N</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>M7P</scope><scope>M7Z</scope><scope>MBDVC</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20170501</creationdate><title>Fun cube based brain gym cognitive function assessment system</title><author>Zhang, Tao ; Lin, Chung-Chih ; Yu, Tsang-Chu ; Sun, Jing ; Hsu, Wen-Chuin ; Wong, Alice May-Kuen</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c510t-7b4802526001ee272098e25ec96377d996de53dc9987c564f8c06bb19c048e983</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Acceptance tests</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Aging</topic><topic>Alzheimer's disease</topic><topic>Blindness</topic><topic>Brain</topic><topic>Brain - physiology</topic><topic>Brain gym</topic><topic>Cognition &amp; reasoning</topic><topic>Cognition - physiology</topic><topic>Cognitive ability</topic><topic>Cognitive Dysfunction - diagnosis</topic><topic>Cognitive function impairment</topic><topic>Color</topic><topic>Computer Communication Networks</topic><topic>Correlation coefficient</topic><topic>Correlation coefficients</topic><topic>Data base management systems</topic><topic>Data transmission</topic><topic>Dementia</topic><topic>Feedback</topic><topic>Female</topic><topic>Fun cube</topic><topic>Games</topic><topic>Geriatrics</topic><topic>Humans</topic><topic>Impairment</topic><topic>Information management</topic><topic>Information systems</topic><topic>Interactive computer systems</topic><topic>Interactive systems</topic><topic>Internal Medicine</topic><topic>Male</topic><topic>Man-machine interfaces</topic><topic>Memory</topic><topic>Multimedia</topic><topic>Neuropsychological Tests</topic><topic>Older people</topic><topic>Other</topic><topic>Personal computers</topic><topic>Risk groups</topic><topic>Sensors</topic><topic>Statistical analysis</topic><topic>Technology utilization</topic><topic>Video Games</topic><topic>Wireless communications</topic><topic>Wireless sensor network</topic><topic>Wireless sensor networks</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zhang, Tao</creatorcontrib><creatorcontrib>Lin, Chung-Chih</creatorcontrib><creatorcontrib>Yu, Tsang-Chu</creatorcontrib><creatorcontrib>Sun, Jing</creatorcontrib><creatorcontrib>Hsu, Wen-Chuin</creatorcontrib><creatorcontrib>Wong, Alice May-Kuen</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing &amp; Allied Health Database</collection><collection>Health &amp; Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Computing Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies &amp; Aerospace Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Computer Science Collection</collection><collection>Computer Science Database</collection><collection>ProQuest Health &amp; Medical Complete (Alumni)</collection><collection>Nursing &amp; Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Computing Database</collection><collection>Health &amp; Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Biological Science Database</collection><collection>Biochemistry Abstracts 1</collection><collection>Research Library (Corporate)</collection><collection>Nursing &amp; Allied Health Premium</collection><collection>Advanced Technologies &amp; Aerospace Database</collection><collection>ProQuest Advanced Technologies &amp; Aerospace Collection</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>Computers in biology and medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhang, Tao</au><au>Lin, Chung-Chih</au><au>Yu, Tsang-Chu</au><au>Sun, Jing</au><au>Hsu, Wen-Chuin</au><au>Wong, Alice May-Kuen</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Fun cube based brain gym cognitive function assessment system</atitle><jtitle>Computers in biology and medicine</jtitle><addtitle>Comput Biol Med</addtitle><date>2017-05-01</date><risdate>2017</risdate><volume>84</volume><spage>1</spage><epage>8</epage><pages>1-8</pages><issn>0010-4825</issn><eissn>1879-0534</eissn><abstract>Abstract The aim of this study is to design and develop a fun cube (FC) based brain gym (BG) cognitive function assessment system using the wireless sensor network and multimedia technologies. The system comprised (1) interaction devices, FCs and a workstation used as interactive tools for collecting and transferring data to the server, (2) a BG information management system responsible for managing the cognitive games and storing test results, and (3) a feedback system used for conducting the analysis of cognitive functions to assist caregivers in screening high risk groups with mild cognitive impairment. Three kinds of experiments were performed to evaluate the developed FC-based BG cognitive function assessment system. The experimental results showed that the Pearson correlation coefficient between the system's evaluation outcomes and the traditional Montreal Cognitive Assessment scores was 0.83. The average Technology Acceptance Model 2 score was close to six for 31 elderly subjects. Most subjects considered that the brain games are interesting and the FC human-machine interface is easy to learn and operate. The control group and the cognitive impairment group had statistically significant difference with respect to the accuracy of and the time taken for the brain cognitive function assessment games, including Animal Naming, Color Search, Trail Making Test, Change Blindness, and Forward / Backward Digit Span.</abstract><cop>United States</cop><pub>Elsevier Ltd</pub><pmid>28315750</pmid><doi>10.1016/j.compbiomed.2017.03.003</doi><tpages>8</tpages></addata></record>
fulltext fulltext
identifier ISSN: 0010-4825
ispartof Computers in biology and medicine, 2017-05, Vol.84, p.1-8
issn 0010-4825
1879-0534
language eng
recordid cdi_proquest_miscellaneous_1879190776
source MEDLINE; Access via ScienceDirect (Elsevier); ProQuest Central UK/Ireland
subjects Acceptance tests
Aged
Aged, 80 and over
Aging
Alzheimer's disease
Blindness
Brain
Brain - physiology
Brain gym
Cognition & reasoning
Cognition - physiology
Cognitive ability
Cognitive Dysfunction - diagnosis
Cognitive function impairment
Color
Computer Communication Networks
Correlation coefficient
Correlation coefficients
Data base management systems
Data transmission
Dementia
Feedback
Female
Fun cube
Games
Geriatrics
Humans
Impairment
Information management
Information systems
Interactive computer systems
Interactive systems
Internal Medicine
Male
Man-machine interfaces
Memory
Multimedia
Neuropsychological Tests
Older people
Other
Personal computers
Risk groups
Sensors
Statistical analysis
Technology utilization
Video Games
Wireless communications
Wireless sensor network
Wireless sensor networks
title Fun cube based brain gym cognitive function assessment system
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-26T14%3A52%3A49IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Fun%20cube%20based%20brain%20gym%20cognitive%20function%20assessment%20system&rft.jtitle=Computers%20in%20biology%20and%20medicine&rft.au=Zhang,%20Tao&rft.date=2017-05-01&rft.volume=84&rft.spage=1&rft.epage=8&rft.pages=1-8&rft.issn=0010-4825&rft.eissn=1879-0534&rft_id=info:doi/10.1016/j.compbiomed.2017.03.003&rft_dat=%3Cproquest_cross%3E1879190776%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1892784441&rft_id=info:pmid/28315750&rft_els_id=1_s2_0_S0010482517300537&rfr_iscdi=true