Influence of different processing times on the quality of Polygoni Multiflora Radix by metabolomics based on ultra high performance liquid chromatography with quadrupole time‐of‐flight mass spectrometry
A metabolomics method based on ultra high performance liquid chromatography with quadrupole time‐of‐flight mass spectrometry was developed to evaluate the influence of processing times on the quality of raw and processed Polygoni Multiflora Radix. Principal component analysis and partial least‐squar...
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| Veröffentlicht in: | Journal of separation science 2017-05, Vol.40 (9), p.1928-1941 |
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| container_issue | 9 |
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| container_title | Journal of separation science |
| container_volume | 40 |
| creator | Yu, Xie‐an Ge, Ai‐hua Zhang, Lu Li, Jin An, Mingrui Cao, Jun He, Jun Gao, Xiu‐mei Chang, Yan‐xu |
| description | A metabolomics method based on ultra high performance liquid chromatography with quadrupole time‐of‐flight mass spectrometry was developed to evaluate the influence of processing times on the quality of raw and processed Polygoni Multiflora Radix. Principal component analysis and partial least‐squares discriminant analysis was used to screen the potential maker metabolites that were contributed to the quality changes. Then these marker metabolites were selected as variables in Fisher's discriminant analysis to establish the models that were used to distinguish the raw and processed Polygoni Multiflora Radix in the markets. Additionally, 36 compounds were identified. Twelve raw Polygoni Multiflora Radix samples and 23 processed Polygoni Multiflora Radix samples were distinguished. The results showed that the 12 raw Polygoni Multiflora Radix samples belonged to the group of processing time of 0 h, and two processed Polygoni Multiflora Radix samples were part of the group of processing times of 4 h, 12 samples belonged to group of processing times of 8 to 16 h, and nine samples were the group of processing times of 24 to 48 h. The results demonstrated that the method could provide scientific support for the processing standardization of Polygoni Multiflora Radix. |
| doi_str_mv | 10.1002/jssc.201600913 |
| format | Article |
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Principal component analysis and partial least‐squares discriminant analysis was used to screen the potential maker metabolites that were contributed to the quality changes. Then these marker metabolites were selected as variables in Fisher's discriminant analysis to establish the models that were used to distinguish the raw and processed Polygoni Multiflora Radix in the markets. Additionally, 36 compounds were identified. Twelve raw Polygoni Multiflora Radix samples and 23 processed Polygoni Multiflora Radix samples were distinguished. The results showed that the 12 raw Polygoni Multiflora Radix samples belonged to the group of processing time of 0 h, and two processed Polygoni Multiflora Radix samples were part of the group of processing times of 4 h, 12 samples belonged to group of processing times of 8 to 16 h, and nine samples were the group of processing times of 24 to 48 h. The results demonstrated that the method could provide scientific support for the processing standardization of Polygoni Multiflora Radix.</description><identifier>ISSN: 1615-9306</identifier><identifier>EISSN: 1615-9314</identifier><identifier>DOI: 10.1002/jssc.201600913</identifier><identifier>PMID: 28317248</identifier><language>eng</language><publisher>Germany: Wiley Subscription Services, Inc</publisher><subject>Chromatography ; Chromatography, High Pressure Liquid ; Discriminant analysis ; Drugs, Chinese Herbal - chemistry ; Fisher's discriminant analysis ; High performance liquid chromatography ; Ions ; Mass Spectrometry ; Metabolites ; Metabolomics ; Plant Roots - chemistry ; Polygoni Multiflora Radix ; Polygonum - chemistry ; principal component analysis ; Principal components analysis ; Production scheduling ; Quadrupoles ; Quality ; Scientific imaging ; Spectroscopy ; Standardization ; Time Factors ; traditional Chinese medicine</subject><ispartof>Journal of separation science, 2017-05, Vol.40 (9), p.1928-1941</ispartof><rights>2017 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim</rights><rights>2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.</rights><rights>2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4058-4f3303f8782af9b06207ebabbf6067b31a1392251207bc1da4a9829206899b4c3</citedby><cites>FETCH-LOGICAL-c4058-4f3303f8782af9b06207ebabbf6067b31a1392251207bc1da4a9829206899b4c3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fjssc.201600913$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fjssc.201600913$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1416,27923,27924,45573,45574</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28317248$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yu, Xie‐an</creatorcontrib><creatorcontrib>Ge, Ai‐hua</creatorcontrib><creatorcontrib>Zhang, Lu</creatorcontrib><creatorcontrib>Li, Jin</creatorcontrib><creatorcontrib>An, Mingrui</creatorcontrib><creatorcontrib>Cao, Jun</creatorcontrib><creatorcontrib>He, Jun</creatorcontrib><creatorcontrib>Gao, Xiu‐mei</creatorcontrib><creatorcontrib>Chang, Yan‐xu</creatorcontrib><title>Influence of different processing times on the quality of Polygoni Multiflora Radix by metabolomics based on ultra high performance liquid chromatography with quadrupole time‐of‐flight mass spectrometry</title><title>Journal of separation science</title><addtitle>J Sep Sci</addtitle><description>A metabolomics method based on ultra high performance liquid chromatography with quadrupole time‐of‐flight mass spectrometry was developed to evaluate the influence of processing times on the quality of raw and processed Polygoni Multiflora Radix. Principal component analysis and partial least‐squares discriminant analysis was used to screen the potential maker metabolites that were contributed to the quality changes. Then these marker metabolites were selected as variables in Fisher's discriminant analysis to establish the models that were used to distinguish the raw and processed Polygoni Multiflora Radix in the markets. Additionally, 36 compounds were identified. Twelve raw Polygoni Multiflora Radix samples and 23 processed Polygoni Multiflora Radix samples were distinguished. The results showed that the 12 raw Polygoni Multiflora Radix samples belonged to the group of processing time of 0 h, and two processed Polygoni Multiflora Radix samples were part of the group of processing times of 4 h, 12 samples belonged to group of processing times of 8 to 16 h, and nine samples were the group of processing times of 24 to 48 h. The results demonstrated that the method could provide scientific support for the processing standardization of Polygoni Multiflora Radix.</description><subject>Chromatography</subject><subject>Chromatography, High Pressure Liquid</subject><subject>Discriminant analysis</subject><subject>Drugs, Chinese Herbal - chemistry</subject><subject>Fisher's discriminant analysis</subject><subject>High performance liquid chromatography</subject><subject>Ions</subject><subject>Mass Spectrometry</subject><subject>Metabolites</subject><subject>Metabolomics</subject><subject>Plant Roots - chemistry</subject><subject>Polygoni Multiflora Radix</subject><subject>Polygonum - chemistry</subject><subject>principal component analysis</subject><subject>Principal components analysis</subject><subject>Production scheduling</subject><subject>Quadrupoles</subject><subject>Quality</subject><subject>Scientific imaging</subject><subject>Spectroscopy</subject><subject>Standardization</subject><subject>Time Factors</subject><subject>traditional Chinese medicine</subject><issn>1615-9306</issn><issn>1615-9314</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkbuO1DAUhiMEYpeFlhJZoqGZwZdc7BKNuCxaBGKhjmzneOKRE2dsR0s6HoEn4yF4Ehxm2YKGxraOvvOdI_9F8ZTgLcGYvjzEqLcUkxpjQdi94pzUpNoIRsr7d29cnxWPYjxgTBou8MPijHJGGlry8-Ln5WjcDKMG5A3qrDEQYExoCl5DjHbco2QHiMiPKPWAjrN0Ni0r_Mm7Ze9Hiz7MLlnjfJDos-zsN6QWNECSyjs_WB2RkhG61ZDBDPV236MJgvFhkOtkZ4-z7ZDugx9k8vsgp35BNzb167wuzJN38GePX99_eJMP47IjoUHGiOIEOuVOSGF5XDww0kV4cntfFF_fvP6ye7e5-vj2cvfqaqNLXPFNaRjDzPCGU2mEwjXFDSiplKlx3ShGJGGC0orkutKkk6UUnAqKay6EKjW7KF6cvPmfjjPE1A42anBOjuDn2BLeCCJwQ6uMPv8HPfg5jHm7TIka05pXJFPbE6WDjzGAaadgBxmWluB2Tbpdk27vks4Nz261sxqgu8P_RpuB8gTcWAfLf3Tt--vrXcUazn4DRN-7gA</recordid><startdate>201705</startdate><enddate>201705</enddate><creator>Yu, Xie‐an</creator><creator>Ge, Ai‐hua</creator><creator>Zhang, Lu</creator><creator>Li, Jin</creator><creator>An, Mingrui</creator><creator>Cao, Jun</creator><creator>He, Jun</creator><creator>Gao, Xiu‐mei</creator><creator>Chang, Yan‐xu</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7U5</scope><scope>8FD</scope><scope>L7M</scope><scope>7X8</scope></search><sort><creationdate>201705</creationdate><title>Influence of different processing times on the quality of Polygoni Multiflora Radix by metabolomics based on ultra high performance liquid chromatography with quadrupole time‐of‐flight mass spectrometry</title><author>Yu, Xie‐an ; Ge, Ai‐hua ; Zhang, Lu ; Li, Jin ; An, Mingrui ; Cao, Jun ; He, Jun ; Gao, Xiu‐mei ; Chang, Yan‐xu</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4058-4f3303f8782af9b06207ebabbf6067b31a1392251207bc1da4a9829206899b4c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Chromatography</topic><topic>Chromatography, High Pressure Liquid</topic><topic>Discriminant analysis</topic><topic>Drugs, Chinese Herbal - chemistry</topic><topic>Fisher's discriminant analysis</topic><topic>High performance liquid chromatography</topic><topic>Ions</topic><topic>Mass Spectrometry</topic><topic>Metabolites</topic><topic>Metabolomics</topic><topic>Plant Roots - chemistry</topic><topic>Polygoni Multiflora Radix</topic><topic>Polygonum - chemistry</topic><topic>principal component analysis</topic><topic>Principal components analysis</topic><topic>Production scheduling</topic><topic>Quadrupoles</topic><topic>Quality</topic><topic>Scientific imaging</topic><topic>Spectroscopy</topic><topic>Standardization</topic><topic>Time Factors</topic><topic>traditional Chinese medicine</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Yu, Xie‐an</creatorcontrib><creatorcontrib>Ge, Ai‐hua</creatorcontrib><creatorcontrib>Zhang, Lu</creatorcontrib><creatorcontrib>Li, Jin</creatorcontrib><creatorcontrib>An, Mingrui</creatorcontrib><creatorcontrib>Cao, Jun</creatorcontrib><creatorcontrib>He, Jun</creatorcontrib><creatorcontrib>Gao, Xiu‐mei</creatorcontrib><creatorcontrib>Chang, Yan‐xu</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Solid State and Superconductivity Abstracts</collection><collection>Technology Research Database</collection><collection>Advanced Technologies Database with Aerospace</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of separation science</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Yu, Xie‐an</au><au>Ge, Ai‐hua</au><au>Zhang, Lu</au><au>Li, Jin</au><au>An, Mingrui</au><au>Cao, Jun</au><au>He, Jun</au><au>Gao, Xiu‐mei</au><au>Chang, Yan‐xu</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Influence of different processing times on the quality of Polygoni Multiflora Radix by metabolomics based on ultra high performance liquid chromatography with quadrupole time‐of‐flight mass spectrometry</atitle><jtitle>Journal of separation science</jtitle><addtitle>J Sep Sci</addtitle><date>2017-05</date><risdate>2017</risdate><volume>40</volume><issue>9</issue><spage>1928</spage><epage>1941</epage><pages>1928-1941</pages><issn>1615-9306</issn><eissn>1615-9314</eissn><abstract>A metabolomics method based on ultra high performance liquid chromatography with quadrupole time‐of‐flight mass spectrometry was developed to evaluate the influence of processing times on the quality of raw and processed Polygoni Multiflora Radix. Principal component analysis and partial least‐squares discriminant analysis was used to screen the potential maker metabolites that were contributed to the quality changes. Then these marker metabolites were selected as variables in Fisher's discriminant analysis to establish the models that were used to distinguish the raw and processed Polygoni Multiflora Radix in the markets. Additionally, 36 compounds were identified. Twelve raw Polygoni Multiflora Radix samples and 23 processed Polygoni Multiflora Radix samples were distinguished. The results showed that the 12 raw Polygoni Multiflora Radix samples belonged to the group of processing time of 0 h, and two processed Polygoni Multiflora Radix samples were part of the group of processing times of 4 h, 12 samples belonged to group of processing times of 8 to 16 h, and nine samples were the group of processing times of 24 to 48 h. The results demonstrated that the method could provide scientific support for the processing standardization of Polygoni Multiflora Radix.</abstract><cop>Germany</cop><pub>Wiley Subscription Services, Inc</pub><pmid>28317248</pmid><doi>10.1002/jssc.201600913</doi><tpages>14</tpages></addata></record> |
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| subjects | Chromatography Chromatography, High Pressure Liquid Discriminant analysis Drugs, Chinese Herbal - chemistry Fisher's discriminant analysis High performance liquid chromatography Ions Mass Spectrometry Metabolites Metabolomics Plant Roots - chemistry Polygoni Multiflora Radix Polygonum - chemistry principal component analysis Principal components analysis Production scheduling Quadrupoles Quality Scientific imaging Spectroscopy Standardization Time Factors traditional Chinese medicine |
| title | Influence of different processing times on the quality of Polygoni Multiflora Radix by metabolomics based on ultra high performance liquid chromatography with quadrupole time‐of‐flight mass spectrometry |
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