Synthesis of Polysubstituted 3‑Amino Pyrroles via Palladium-Catalyzed Multicomponent Reaction

Synthesis of Polysubstituted 3‑Amino Pyrroles via Palladium-Catalyzed Multicomponent Reaction

A novel approach for the synthesis of polysubstituted 3-amino pyrroles via palladium-catalyzed three-component tandem reaction was developed. The procedure constructs various polysubstituted 3-amino pyrroles with moderate to excellent yields under mild reaction conditions with assembly efficiency, r...

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Veröffentlicht in:Journal of organic chemistry 2017-04, Vol.82 (7), p.3581-3588
Hauptverfasser: Peng, Jianwen, Gao, Yang, Zhu, Chuanle, Liu, Bifu, Gao, Yinglan, Hu, Miao, Wu, Wanqing, Jiang, Huanfeng
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container_end_page 3588
container_issue 7
container_start_page 3581
container_title Journal of organic chemistry
container_volume 82
creator Peng, Jianwen
Gao, Yang
Zhu, Chuanle
Liu, Bifu
Gao, Yinglan
Hu, Miao
Wu, Wanqing
Jiang, Huanfeng
description A novel approach for the synthesis of polysubstituted 3-amino pyrroles via palladium-catalyzed three-component tandem reaction was developed. The procedure constructs various polysubstituted 3-amino pyrroles with moderate to excellent yields under mild reaction conditions with assembly efficiency, readily available starting materials, and good functional group tolerance. Furthermore, this process was successfully applied to the synthesis of different 3-phenyl-1,4-dihydropyrrolo­[3,2-b]­indole derivatives via an intramolecular Buchwald–Hartwig cross-coupling reaction in two steps.
doi_str_mv 10.1021/acs.joc.7b00098
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title Synthesis of Polysubstituted 3‑Amino Pyrroles via Palladium-Catalyzed Multicomponent Reaction
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