Methyl Protodioscin Induces Apoptosis in Human Osteosarcoma Cells by Caspase-Dependent and MAPK Signaling Pathways

Methyl protodioscin (MPD), a furostanol saponin derived from the rhizomes of Dioscorea collettii var. hypoglauca (Dioscoreaceae), has been shown to exhibit broad bioactivities such as anti-inflammation and antitumor activities. Here, we explored the molecular mechanisms by which MPD induced apoptosi...

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Veröffentlicht in:	Journal of agricultural and food chemistry 2017-04, Vol.65 (13), p.2670-2676
Hauptverfasser:	Tseng, Shun-Cheng, Shen, Tai-Shan, Wu, Chia-Chieh, Chang, Ing-Lin, Chen, Hsin-Yao, Hsieh, Chen-Pu, Cheng, Chun-Hsiang, Chen, Chiu-Liang
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis - drug effects bcl-2-Associated X Protein - genetics bcl-2-Associated X Protein - metabolism Bone Neoplasms - drug therapy Bone Neoplasms - enzymology Bone Neoplasms - genetics Bone Neoplasms - physiopathology Caspase 3 - genetics Caspase 3 - metabolism Caspase 9 - genetics Caspase 9 - metabolism Cell Line, Tumor Dioscorea - chemistry Diosgenin - analogs & derivatives Diosgenin - pharmacology Humans JNK Mitogen-Activated Protein Kinases - genetics JNK Mitogen-Activated Protein Kinases - metabolism MAP Kinase Signaling System - drug effects Membrane Potential, Mitochondrial - drug effects Osteosarcoma - drug therapy Osteosarcoma - enzymology Osteosarcoma - genetics Osteosarcoma - physiopathology Phosphorylation Plant Extracts - pharmacology Saponins - pharmacology
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