Nicotine Promotes Cholangiocarcinoma Growth in Xenograft Mice

Nicotine, the main addictive substance in tobacco, is known to play a role in the development and/or progression of a number of malignant tumors. However, nicotine's involvement in the pathogenesis of cholangiocarcinoma is controversial. Therefore, we studied the effects of nicotine on the grow...

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Veröffentlicht in:	The American journal of pathology 2017-05, Vol.187 (5), p.1093-1105
Hauptverfasser:	Martínez, Allyson K, Jensen, Kendal, Hall, Chad, O'Brien, April, Ehrlich, Laurent, White, Tori, Meng, Fanyin, Zhou, Tianhao, Greene, John, Bernuzzi, Francesca, Invernizzi, Pietro, Dostal, David E, Lairmore, Terry, Alpini, Gianfranco, Glaser, Shannon
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged alpha7 Nicotinic Acetylcholine Receptor - physiology Animals Bile Duct Neoplasms - metabolism Bile Duct Neoplasms - pathology Cell Line, Tumor Cell Proliferation - drug effects Cholangiocarcinoma - metabolism Cholangiocarcinoma - pathology Extracellular Signal-Regulated MAP Kinases - metabolism Female Fibrosis - metabolism Heterografts Humans Keratin-19 - metabolism Male MAP Kinase Signaling System - physiology Mice Middle Aged Neoplasm Transplantation Nicotine - pharmacology Nicotinic Agonists - pharmacology Pathology S100 Calcium-Binding Protein A4 - metabolism
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