New Approach and Practical Modelling of Bead Milling Process for the Manufacturing of Nanocrystalline Suspensions
Stirred media milling is the main technology for producing colloidal nanocrystalline suspensions. A number of studies have been reported on the effect of different operating parameters for lab, pilot, and industrial scales. However, typical milling tool box that can be used to support candidate from...
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| Veröffentlicht in: | Journal of pharmaceutical sciences 2017-07, Vol.106 (7), p.1889-1904 |
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| container_end_page | 1904 |
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| container_issue | 7 |
| container_start_page | 1889 |
| container_title | Journal of pharmaceutical sciences |
| container_volume | 106 |
| creator | Nakach, Mostafa Authelin, Jean-René Agut, Christophe |
| description | Stirred media milling is the main technology for producing colloidal nanocrystalline suspensions. A number of studies have been reported on the effect of different operating parameters for lab, pilot, and industrial scales. However, typical milling tool box that can be used to support candidate from selection up to phase III clinical supplies can involve different mill configurations. This article describes a parametric study and milling kinetic modelling of the different mills. The impact of active pharmaceutical ingredient (API) type and process parameters on milling kinetics was determined. The milling kinetics were modeled using an empirical model which allows for predicting and simulation of milling kinetics of stirred annular and pin mills. The proposed model was found to accurately fit milling kinetics whatever the API considered, technology employed, and the process parameters used for milling. Moreover, the model was found to be able to ensure the process transfer from one mill to another. |
| doi_str_mv | 10.1016/j.xphs.2017.02.036 |
| format | Article |
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A number of studies have been reported on the effect of different operating parameters for lab, pilot, and industrial scales. However, typical milling tool box that can be used to support candidate from selection up to phase III clinical supplies can involve different mill configurations. This article describes a parametric study and milling kinetic modelling of the different mills. The impact of active pharmaceutical ingredient (API) type and process parameters on milling kinetics was determined. The milling kinetics were modeled using an empirical model which allows for predicting and simulation of milling kinetics of stirred annular and pin mills. The proposed model was found to accurately fit milling kinetics whatever the API considered, technology employed, and the process parameters used for milling. Moreover, the model was found to be able to ensure the process transfer from one mill to another.</description><identifier>ISSN: 0022-3549</identifier><identifier>EISSN: 1520-6017</identifier><identifier>DOI: 10.1016/j.xphs.2017.02.036</identifier><identifier>PMID: 28302540</identifier><language>eng</language><publisher>United States: Elsevier Inc</publisher><subject>Algorithms ; Avrami equation ; Drug Compounding - instrumentation ; Drug Compounding - methods ; Equipment Design ; Excipients - chemistry ; Kinetics ; modelling ; Models, Chemical ; nanocrystalline suspension ; Nanoparticles - chemistry ; Nanotechnology - instrumentation ; Nanotechnology - methods ; Particle Size ; Pharmaceutical Preparations - chemistry ; Solubility ; stirred bead milling ; Suspensions</subject><ispartof>Journal of pharmaceutical sciences, 2017-07, Vol.106 (7), p.1889-1904</ispartof><rights>2017 American Pharmacists Association</rights><rights>Copyright © 2017 American Pharmacists Association®. 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| ispartof | Journal of pharmaceutical sciences, 2017-07, Vol.106 (7), p.1889-1904 |
| issn | 0022-3549 1520-6017 |
| language | eng |
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| source | MEDLINE; Alma/SFX Local Collection |
| subjects | Algorithms Avrami equation Drug Compounding - instrumentation Drug Compounding - methods Equipment Design Excipients - chemistry Kinetics modelling Models, Chemical nanocrystalline suspension Nanoparticles - chemistry Nanotechnology - instrumentation Nanotechnology - methods Particle Size Pharmaceutical Preparations - chemistry Solubility stirred bead milling Suspensions |
| title | New Approach and Practical Modelling of Bead Milling Process for the Manufacturing of Nanocrystalline Suspensions |
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