Noninvasive Imaging of Cycling Hypoxia in Head and Neck Cancer Using Intrinsic Susceptibility MRI

To evaluate intrinsic susceptibility (IS) MRI for the identification of cycling hypoxia, and the assessment of its extent and spatial distribution, in head and neck squamous cell carcinoma (HNSCC) xenografts and patients. Quantitation of the transverse relaxation rate, R *, which is sensitive to par...

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Veröffentlicht in:	Clinical cancer research 2017-08, Vol.23 (15), p.4233-4241
Hauptverfasser:	Panek, Rafal, Welsh, Liam, Baker, Lauren C J, Schmidt, Maria A, Wong, Kee H, Riddell, Angela M, Koh, Dow-Mu, Dunlop, Alex, Mcquaid, Dualta, d'Arcy, James A, Bhide, Shreerang A, Harrington, Kevin J, Nutting, Christopher M, Hopkinson, Georgina, Richardson, Cheryl, Box, Carol, Eccles, Suzanne A, Leach, Martin O, Robinson, Simon P, Newbold, Kate L
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Cancer Carcinoma, Squamous Cell - diagnostic imaging Carcinoma, Squamous Cell - drug therapy Carcinoma, Squamous Cell - pathology Cell Hypoxia - genetics Cell Line, Tumor Contrast Media - therapeutic use Cores Cycles Experimental design Female Fluctuations Head Head & neck cancer Head and Neck Neoplasms - diagnostic imaging Head and Neck Neoplasms - drug therapy Head and Neck Neoplasms - pathology Humans Hypoxia Lymph nodes Lymph Nodes - diagnostic imaging Lymph Nodes - pathology Magnetic Resonance Imaging Male Mice Neovascularization, Pathologic - diagnostic imaging Neovascularization, Pathologic - drug therapy Neovascularization, Pathologic - pathology Nitroimidazoles - administration & dosage Oscillations Oxygenation Patients Perfusion Periodic variations Periodicity Power spectrum analysis Quantitation Radiation Tolerance - drug effects Spatial distribution Squamous cell carcinoma Squamous Cell Carcinoma of Head and Neck Treatment Outcome Tumors Vascularization Xenograft Model Antitumor Assays Xenografts
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