Liraglutide acutely suppresses glucagon, lipolysis and ketogenesis in type 1 diabetes

In view of the occurrence of diabetic ketoacidosis associated with the use of sodium‐glucose transport protein‐2 inhibitors in patients with type 1 diabetes (T1DM) and the relative absence of this complication in patients treated with liraglutide in spite of reductions in insulin doses, we investiga...

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Veröffentlicht in:	Diabetes, obesity & metabolism obesity & metabolism, 2017-09, Vol.19 (9), p.1306-1311
Hauptverfasser:	Garg, Manisha, Ghanim, Husam, Kuhadiya, Nitesh D., Green, Kelly, Hejna, Jeanne, Abuaysheh, Sanaa, Torre, Barrett, Batra, Manav, Makdissi, Antoine, Chaudhuri, Ajay, Dandona, Paresh
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Antidiabetics Diabetes Diabetes mellitus Diabetes Mellitus, Type 1 - blood Diabetes Mellitus, Type 1 - drug therapy Diabetes Mellitus, Type 1 - metabolism Diabetic ketoacidosis Double-Blind Method Drug Resistance Drug Therapy, Combination Fatty acids Fatty Acids, Nonesterified - antagonists & inhibitors Fatty Acids, Nonesterified - blood Female Ghrelin Ghrelin - antagonists & inhibitors Ghrelin - blood Glucagon Glucagon - antagonists & inhibitors Glucagon - blood Glucagon-Like Peptide-1 Receptor - agonists Glucagon-Like Peptide-1 Receptor - metabolism Glucose Glucose transport Humans Hypoglycemic Agents - administration & dosage Hypoglycemic Agents - therapeutic use Injections, Subcutaneous Insulin Insulin - administration & dosage Insulin - therapeutic use Insulin Infusion Systems Ketoacidosis Ketogenesis Ketone Bodies - antagonists & inhibitors Ketone Bodies - biosynthesis Ketone Bodies - blood Lipolysis Lipolysis - drug effects liraglutide Liraglutide - administration & dosage Liraglutide - therapeutic use Male Middle Aged Protein transport Sodium Sodium-glucose cotransporter type 1 diabetes
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