Permanent hair dyes and bladder cancer: risk modification by cytochrome P4501A2 and N-acetyltransferases 1 and 2
We have previously reported permanent hair dye use to be a significant risk factor for bladder cancer in US women. We also have examined N-acetyltransferase-2 (NAT2) phenotype in relation to the hair dye–bladder cancer relationship, and found that the association is principally confined to NAT2 slow...
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| Veröffentlicht in: | Carcinogenesis (New York) 2003-03, Vol.24 (3), p.483-489 |
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| creator | Gago-Dominguez, Manuela Bell, Douglas A. Watson, Mary A. Yuan, Jian-Min Castelao, J.Esteban Hein, David W. Chan, Kenneth K. Coetzee, Gerhard A. Ross, Ronald K. Yu, Mimi C. |
| description | We have previously reported permanent hair dye use to be a significant risk factor for bladder cancer in US women. We also have examined N-acetyltransferase-2 (NAT2) phenotype in relation to the hair dye–bladder cancer relationship, and found that the association is principally confined to NAT2 slow acetylators. In the present study, we assessed the possible modifying effects of a series of potential arylamine-metabolizing genotypes/phenotypes (GSTM1, GSTT1, GSTP1, NAT1, NAT2, CYP1A2) on the permanent hair dye–bladder cancer association, among female participants (159 cases, 164 controls) of the Los Angeles Bladder Cancer Study. Among NAT2 slow acetylators, exclusive permanent hair dye use was associated with a 2.9-fold increased risk of bladder cancer (95% CI = 1.2–7.5). The corresponding relative risk in NAT2 rapid acetylators was 1.3 (95% CI = 0.6–2.8). Frequency- and duration-related dose–response relationships confined to NAT2 slow acetylators were all positive and statistically significant. No such associations were noted among NAT2 rapid acetylators. Among CYP1A2 ‘slow’ individuals, exclusive permanent hair dye use was associated with a 2.5-fold increased risk of bladder cancer (95% CI = 1.04–6.1). The corresponding risk in CYP1A2 ‘rapid’ individuals was 1.3 (95% CI = 0.6–2.7). Frequency- and duration-related dose–response relationships confined to CYP1A2 ‘slow’ individuals were all positive and statistically significant. No such associations were noted among CYP1A2 ‘rapid’ individuals. Among lifelong non-smoking women, individuals exhibiting the non-NAT1*10 genotype showed a statistically significant increase in bladder cancer risk associated with exclusive permanent hair dye use (OR = 6.8, 95% CI = 1.7–27.4). The comparable OR in individuals with the NAT1*10 genotype was 1.0 (95%CI = 0.2–4.3). Similarly, all frequency- and duration-related dose–response relationships confined to individuals possessing the non-NAT1*10 genotype were positive and statistically significant. On the other hand, individuals of NAT1*10 genotype exhibited no such associations. |
| doi_str_mv | 10.1093/carcin/24.3.483 |
| format | Article |
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We also have examined N-acetyltransferase-2 (NAT2) phenotype in relation to the hair dye–bladder cancer relationship, and found that the association is principally confined to NAT2 slow acetylators. In the present study, we assessed the possible modifying effects of a series of potential arylamine-metabolizing genotypes/phenotypes (GSTM1, GSTT1, GSTP1, NAT1, NAT2, CYP1A2) on the permanent hair dye–bladder cancer association, among female participants (159 cases, 164 controls) of the Los Angeles Bladder Cancer Study. Among NAT2 slow acetylators, exclusive permanent hair dye use was associated with a 2.9-fold increased risk of bladder cancer (95% CI = 1.2–7.5). The corresponding relative risk in NAT2 rapid acetylators was 1.3 (95% CI = 0.6–2.8). Frequency- and duration-related dose–response relationships confined to NAT2 slow acetylators were all positive and statistically significant. No such associations were noted among NAT2 rapid acetylators. Among CYP1A2 ‘slow’ individuals, exclusive permanent hair dye use was associated with a 2.5-fold increased risk of bladder cancer (95% CI = 1.04–6.1). The corresponding risk in CYP1A2 ‘rapid’ individuals was 1.3 (95% CI = 0.6–2.7). Frequency- and duration-related dose–response relationships confined to CYP1A2 ‘slow’ individuals were all positive and statistically significant. No such associations were noted among CYP1A2 ‘rapid’ individuals. Among lifelong non-smoking women, individuals exhibiting the non-NAT1*10 genotype showed a statistically significant increase in bladder cancer risk associated with exclusive permanent hair dye use (OR = 6.8, 95% CI = 1.7–27.4). The comparable OR in individuals with the NAT1*10 genotype was 1.0 (95%CI = 0.2–4.3). Similarly, all frequency- and duration-related dose–response relationships confined to individuals possessing the non-NAT1*10 genotype were positive and statistically significant. On the other hand, individuals of NAT1*10 genotype exhibited no such associations.</description><identifier>ISSN: 0143-3334</identifier><identifier>ISSN: 1460-2180</identifier><identifier>EISSN: 1460-2180</identifier><identifier>DOI: 10.1093/carcin/24.3.483</identifier><identifier>PMID: 12663508</identifier><identifier>CODEN: CRNGDP</identifier><language>eng</language><publisher>Oxford: Oxford University Press</publisher><subject>4-ABP ; 4-aminobiphenyl ; Adult ; Arylamine N-Acetyltransferase - metabolism ; Biological and medical sciences ; confidence interval ; Cytochrome P-450 CYP1A2 - metabolism ; DAPPD ; Female ; Genotype ; Glutathione S-transferases ; GSTs ; Hair Dyes - adverse effects ; Humans ; Isoenzymes - metabolism ; MAPPD ; Medical sciences ; Middle Aged ; monoracetyl-PPD ; N-acetyltransferase-2 ; NAT2 ; Nephrology. Urinary tract diseases ; N′-diacetyl-PPD ; paraphenylenediamine ; Phenotype ; PPD ; Tumors of the urinary system ; Urinary Bladder Neoplasms - enzymology ; Urinary Bladder Neoplasms - epidemiology ; Urinary Bladder Neoplasms - etiology ; Urinary tract. Prostate gland</subject><ispartof>Carcinogenesis (New York), 2003-03, Vol.24 (3), p.483-489</ispartof><rights>2004 INIST-CNRS</rights><rights>Copyright Oxford University Press(England) Mar 2003</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c460t-379383bbeb1d5e98b01fd39d3997ad90780779d240a492363e8540cca981ed3d3</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27901,27902</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=14952220$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12663508$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gago-Dominguez, Manuela</creatorcontrib><creatorcontrib>Bell, Douglas A.</creatorcontrib><creatorcontrib>Watson, Mary A.</creatorcontrib><creatorcontrib>Yuan, Jian-Min</creatorcontrib><creatorcontrib>Castelao, J.Esteban</creatorcontrib><creatorcontrib>Hein, David W.</creatorcontrib><creatorcontrib>Chan, Kenneth K.</creatorcontrib><creatorcontrib>Coetzee, Gerhard A.</creatorcontrib><creatorcontrib>Ross, Ronald K.</creatorcontrib><creatorcontrib>Yu, Mimi C.</creatorcontrib><title>Permanent hair dyes and bladder cancer: risk modification by cytochrome P4501A2 and N-acetyltransferases 1 and 2</title><title>Carcinogenesis (New York)</title><addtitle>Carcinogenesis</addtitle><description>We have previously reported permanent hair dye use to be a significant risk factor for bladder cancer in US women. We also have examined N-acetyltransferase-2 (NAT2) phenotype in relation to the hair dye–bladder cancer relationship, and found that the association is principally confined to NAT2 slow acetylators. In the present study, we assessed the possible modifying effects of a series of potential arylamine-metabolizing genotypes/phenotypes (GSTM1, GSTT1, GSTP1, NAT1, NAT2, CYP1A2) on the permanent hair dye–bladder cancer association, among female participants (159 cases, 164 controls) of the Los Angeles Bladder Cancer Study. Among NAT2 slow acetylators, exclusive permanent hair dye use was associated with a 2.9-fold increased risk of bladder cancer (95% CI = 1.2–7.5). The corresponding relative risk in NAT2 rapid acetylators was 1.3 (95% CI = 0.6–2.8). Frequency- and duration-related dose–response relationships confined to NAT2 slow acetylators were all positive and statistically significant. No such associations were noted among NAT2 rapid acetylators. Among CYP1A2 ‘slow’ individuals, exclusive permanent hair dye use was associated with a 2.5-fold increased risk of bladder cancer (95% CI = 1.04–6.1). The corresponding risk in CYP1A2 ‘rapid’ individuals was 1.3 (95% CI = 0.6–2.7). Frequency- and duration-related dose–response relationships confined to CYP1A2 ‘slow’ individuals were all positive and statistically significant. No such associations were noted among CYP1A2 ‘rapid’ individuals. Among lifelong non-smoking women, individuals exhibiting the non-NAT1*10 genotype showed a statistically significant increase in bladder cancer risk associated with exclusive permanent hair dye use (OR = 6.8, 95% CI = 1.7–27.4). The comparable OR in individuals with the NAT1*10 genotype was 1.0 (95%CI = 0.2–4.3). Similarly, all frequency- and duration-related dose–response relationships confined to individuals possessing the non-NAT1*10 genotype were positive and statistically significant. On the other hand, individuals of NAT1*10 genotype exhibited no such associations.</description><subject>4-ABP</subject><subject>4-aminobiphenyl</subject><subject>Adult</subject><subject>Arylamine N-Acetyltransferase - metabolism</subject><subject>Biological and medical sciences</subject><subject>confidence interval</subject><subject>Cytochrome P-450 CYP1A2 - metabolism</subject><subject>DAPPD</subject><subject>Female</subject><subject>Genotype</subject><subject>Glutathione S-transferases</subject><subject>GSTs</subject><subject>Hair Dyes - adverse effects</subject><subject>Humans</subject><subject>Isoenzymes - metabolism</subject><subject>MAPPD</subject><subject>Medical sciences</subject><subject>Middle Aged</subject><subject>monoracetyl-PPD</subject><subject>N-acetyltransferase-2</subject><subject>NAT2</subject><subject>Nephrology. Urinary tract diseases</subject><subject>N′-diacetyl-PPD</subject><subject>paraphenylenediamine</subject><subject>Phenotype</subject><subject>PPD</subject><subject>Tumors of the urinary system</subject><subject>Urinary Bladder Neoplasms - enzymology</subject><subject>Urinary Bladder Neoplasms - epidemiology</subject><subject>Urinary Bladder Neoplasms - etiology</subject><subject>Urinary tract. Prostate gland</subject><issn>0143-3334</issn><issn>1460-2180</issn><issn>1460-2180</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpdkd9rFDEQx4Mo9lp99k2CoG97l2Syu4lvbe1ZS7GFKoovYTbJ0rT740z2wP3vjb3DQmFgBuYzX2bmS8gbzpacaVhZjDYMKyGXsJQKnpEFlxUrBFfsOVkwLqEAAHlADlO6Y4xXUOqX5ICLKldMLcjm2sceBz9M9BZDpG72ieLgaNOhcz5Si4P18SONId3TfnShDRanMA60mamdp9HexrH39FqWjB-Lh9mvBVo_zd0UcUitj5iyKH9oiVfkRYtd8q_3-Yh8X599Oz0vLq8-fzk9vixsPmAqoNagoGl8w13ptWoYbx3oHLpGp1mtWF1rJyRDqQVU4FUpmbWoFfcOHByRDzvdTRx_b32aTB-S9V2Xjx23yXBVKykrnsF3T8C7cRuHvJsRXAPoqtIZWu0gG8eUom_NJoYe42w4M_-cMDsnjJAGTHYiT7zdy26b3rtHfv_6DLzfA5gsdm3-lQ3pkZO6FEKwzBU7LqTJ__nfx3hvqhrq0pz__GV-XIiTm_VamU_wF4ozn6w</recordid><startdate>20030301</startdate><enddate>20030301</enddate><creator>Gago-Dominguez, Manuela</creator><creator>Bell, Douglas A.</creator><creator>Watson, Mary A.</creator><creator>Yuan, Jian-Min</creator><creator>Castelao, J.Esteban</creator><creator>Hein, David W.</creator><creator>Chan, Kenneth K.</creator><creator>Coetzee, Gerhard A.</creator><creator>Ross, Ronald K.</creator><creator>Yu, Mimi C.</creator><general>Oxford University Press</general><general>Oxford Publishing Limited (England)</general><scope>BSCLL</scope><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7TM</scope><scope>7TO</scope><scope>7U7</scope><scope>8FD</scope><scope>C1K</scope><scope>FR3</scope><scope>H94</scope><scope>K9.</scope><scope>P64</scope><scope>RC3</scope></search><sort><creationdate>20030301</creationdate><title>Permanent hair dyes and bladder cancer: risk modification by cytochrome P4501A2 and N-acetyltransferases 1 and 2</title><author>Gago-Dominguez, Manuela ; Bell, Douglas A. ; Watson, Mary A. ; Yuan, Jian-Min ; Castelao, J.Esteban ; Hein, David W. ; Chan, Kenneth K. ; Coetzee, Gerhard A. ; Ross, Ronald K. ; Yu, Mimi C.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c460t-379383bbeb1d5e98b01fd39d3997ad90780779d240a492363e8540cca981ed3d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>4-ABP</topic><topic>4-aminobiphenyl</topic><topic>Adult</topic><topic>Arylamine N-Acetyltransferase - metabolism</topic><topic>Biological and medical sciences</topic><topic>confidence interval</topic><topic>Cytochrome P-450 CYP1A2 - metabolism</topic><topic>DAPPD</topic><topic>Female</topic><topic>Genotype</topic><topic>Glutathione S-transferases</topic><topic>GSTs</topic><topic>Hair Dyes - adverse effects</topic><topic>Humans</topic><topic>Isoenzymes - metabolism</topic><topic>MAPPD</topic><topic>Medical sciences</topic><topic>Middle Aged</topic><topic>monoracetyl-PPD</topic><topic>N-acetyltransferase-2</topic><topic>NAT2</topic><topic>Nephrology. Urinary tract diseases</topic><topic>N′-diacetyl-PPD</topic><topic>paraphenylenediamine</topic><topic>Phenotype</topic><topic>PPD</topic><topic>Tumors of the urinary system</topic><topic>Urinary Bladder Neoplasms - enzymology</topic><topic>Urinary Bladder Neoplasms - epidemiology</topic><topic>Urinary Bladder Neoplasms - etiology</topic><topic>Urinary tract. Prostate gland</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gago-Dominguez, Manuela</creatorcontrib><creatorcontrib>Bell, Douglas A.</creatorcontrib><creatorcontrib>Watson, Mary A.</creatorcontrib><creatorcontrib>Yuan, Jian-Min</creatorcontrib><creatorcontrib>Castelao, J.Esteban</creatorcontrib><creatorcontrib>Hein, David W.</creatorcontrib><creatorcontrib>Chan, Kenneth K.</creatorcontrib><creatorcontrib>Coetzee, Gerhard A.</creatorcontrib><creatorcontrib>Ross, Ronald K.</creatorcontrib><creatorcontrib>Yu, Mimi C.</creatorcontrib><collection>Istex</collection><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Toxicology Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><jtitle>Carcinogenesis (New York)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gago-Dominguez, Manuela</au><au>Bell, Douglas A.</au><au>Watson, Mary A.</au><au>Yuan, Jian-Min</au><au>Castelao, J.Esteban</au><au>Hein, David W.</au><au>Chan, Kenneth K.</au><au>Coetzee, Gerhard A.</au><au>Ross, Ronald K.</au><au>Yu, Mimi C.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Permanent hair dyes and bladder cancer: risk modification by cytochrome P4501A2 and N-acetyltransferases 1 and 2</atitle><jtitle>Carcinogenesis (New York)</jtitle><addtitle>Carcinogenesis</addtitle><date>2003-03-01</date><risdate>2003</risdate><volume>24</volume><issue>3</issue><spage>483</spage><epage>489</epage><pages>483-489</pages><issn>0143-3334</issn><issn>1460-2180</issn><eissn>1460-2180</eissn><coden>CRNGDP</coden><abstract>We have previously reported permanent hair dye use to be a significant risk factor for bladder cancer in US women. We also have examined N-acetyltransferase-2 (NAT2) phenotype in relation to the hair dye–bladder cancer relationship, and found that the association is principally confined to NAT2 slow acetylators. In the present study, we assessed the possible modifying effects of a series of potential arylamine-metabolizing genotypes/phenotypes (GSTM1, GSTT1, GSTP1, NAT1, NAT2, CYP1A2) on the permanent hair dye–bladder cancer association, among female participants (159 cases, 164 controls) of the Los Angeles Bladder Cancer Study. Among NAT2 slow acetylators, exclusive permanent hair dye use was associated with a 2.9-fold increased risk of bladder cancer (95% CI = 1.2–7.5). The corresponding relative risk in NAT2 rapid acetylators was 1.3 (95% CI = 0.6–2.8). Frequency- and duration-related dose–response relationships confined to NAT2 slow acetylators were all positive and statistically significant. No such associations were noted among NAT2 rapid acetylators. Among CYP1A2 ‘slow’ individuals, exclusive permanent hair dye use was associated with a 2.5-fold increased risk of bladder cancer (95% CI = 1.04–6.1). The corresponding risk in CYP1A2 ‘rapid’ individuals was 1.3 (95% CI = 0.6–2.7). Frequency- and duration-related dose–response relationships confined to CYP1A2 ‘slow’ individuals were all positive and statistically significant. No such associations were noted among CYP1A2 ‘rapid’ individuals. Among lifelong non-smoking women, individuals exhibiting the non-NAT1*10 genotype showed a statistically significant increase in bladder cancer risk associated with exclusive permanent hair dye use (OR = 6.8, 95% CI = 1.7–27.4). The comparable OR in individuals with the NAT1*10 genotype was 1.0 (95%CI = 0.2–4.3). Similarly, all frequency- and duration-related dose–response relationships confined to individuals possessing the non-NAT1*10 genotype were positive and statistically significant. On the other hand, individuals of NAT1*10 genotype exhibited no such associations.</abstract><cop>Oxford</cop><pub>Oxford University Press</pub><pmid>12663508</pmid><doi>10.1093/carcin/24.3.483</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Carcinogenesis (New York), 2003-03, Vol.24 (3), p.483-489 |
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| source | Oxford University Press Journals All Titles (1996-Current); MEDLINE; EZB-FREE-00999 freely available EZB journals; Alma/SFX Local Collection |
| subjects | 4-ABP 4-aminobiphenyl Adult Arylamine N-Acetyltransferase - metabolism Biological and medical sciences confidence interval Cytochrome P-450 CYP1A2 - metabolism DAPPD Female Genotype Glutathione S-transferases GSTs Hair Dyes - adverse effects Humans Isoenzymes - metabolism MAPPD Medical sciences Middle Aged monoracetyl-PPD N-acetyltransferase-2 NAT2 Nephrology. Urinary tract diseases N′-diacetyl-PPD paraphenylenediamine Phenotype PPD Tumors of the urinary system Urinary Bladder Neoplasms - enzymology Urinary Bladder Neoplasms - epidemiology Urinary Bladder Neoplasms - etiology Urinary tract. Prostate gland |
| title | Permanent hair dyes and bladder cancer: risk modification by cytochrome P4501A2 and N-acetyltransferases 1 and 2 |
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