Neutrophil elastase inhibitor sivelestat ameliorates gefitinib-naphthalene-induced acute pneumonitis in mice

Gefitinib, an epidermal growth factor receptor-tyrosine kinase inhibitor (EGFR-TKI), is an effective therapeutic agent for non-small cell lung cancer with EGFR mutations. It can cause severe acute pneumonitis in some patients. We previously demonstrated that mice with naphthalene-induced airway epit...

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Veröffentlicht in:	Biochemical and biophysical research communications 2017-04, Vol.486 (1), p.205-209
Hauptverfasser:	Mikumo, Hironori, Yanagihara, Toyoshi, Hamada, Naoki, Harada, Eiji, Ogata-Suetsugu, Saiko, Ikeda-Harada, Chika, Arimura-Omori, Masako, Suzuki, Kunihiro, Yokoyama, Testuya, Nakanishi, Yoichi
Format:	Artikel
Sprache:	eng
Schlagworte:	Acute Disease Acute pneumonitis Animals Bronchoalveolar Lavage Fluid - chemistry Bronchoalveolar Lavage Fluid - cytology Female Gefitinib Glycine - analogs & derivatives Glycine - pharmacology Humans Kaplan-Meier Estimate Leukocyte Count Leukocyte Elastase - antagonists & inhibitors Leukocyte Elastase - metabolism Lung - drug effects Lung - metabolism Lung - pathology Mice, Inbred C57BL Naphthalenes Neutrophil elastase Neutrophils - drug effects Neutrophils - metabolism Pneumonia - chemically induced Pneumonia - prevention & control Quinazolines Serine Proteinase Inhibitors - pharmacology Sulfonamides - pharmacology Weight Loss - drug effects
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