Use of Simvastatin and Risk of Acute Pancreatitis: A Nationwide Case‐Control Study in Taiwan
The correlation between simvastatin use and acute pancreatitis is explored. A case‐control study was conducted to analyze claim data from the Taiwan National Health Insurance Program. The case group comprising a total of 3882 subjects aged 20 to 84 years with their first acute pancreatitis episode o...
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Veröffentlicht in: | Journal of clinical pharmacology 2017-07, Vol.57 (7), p.918-923 |
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description | The correlation between simvastatin use and acute pancreatitis is explored. A case‐control study was conducted to analyze claim data from the Taiwan National Health Insurance Program. The case group comprising a total of 3882 subjects aged 20 to 84 years with their first acute pancreatitis episode occurring between 1998 and 2011 formed the case group, against 3790 randomly selected controls matched for sex, age, comorbidities, and index year of acute pancreatitis diagnosis. Recent use of simvastatin was defined as subjects whose last remaining simvastatin tablet was noted ≤7 days before the date of acute pancreatitis diagnosis. Remote use of simvastatin was defined as subjects whose last remaining 1 tablet for simvastatin was noted >7 days before the date of acute pancreatitis diagnosis. Never use of simvastatin was defined as subjects who had never been prescribed simvastatin. A multivariable unconditional logistic regression model was used to estimate the odds ratio and 95%CI to explore the correlation between simvastatin use and acute pancreatitis. After adjustment for confounders, multivariable logistic regression analysis revealed that the adjusted odds ratio of acute pancreatitis was 1.3 for subjects with recent use of simvastatin (95%CI 1.02, 1.73), when compared with those with never use of simvastatin. The crude odds ratio decreased to 1.1 for those with remote use of simvastatin (95%CI 0.93, 1.34) but without statistical significance. Recent use of simvastatin is associated with acute pancreatitis. Clinicians should consider the possibility of simvastatin‐associated acute pancreatitis for patients presenting for acute pancreatitis without known cause. |
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A case‐control study was conducted to analyze claim data from the Taiwan National Health Insurance Program. The case group comprising a total of 3882 subjects aged 20 to 84 years with their first acute pancreatitis episode occurring between 1998 and 2011 formed the case group, against 3790 randomly selected controls matched for sex, age, comorbidities, and index year of acute pancreatitis diagnosis. Recent use of simvastatin was defined as subjects whose last remaining simvastatin tablet was noted ≤7 days before the date of acute pancreatitis diagnosis. Remote use of simvastatin was defined as subjects whose last remaining 1 tablet for simvastatin was noted >7 days before the date of acute pancreatitis diagnosis. Never use of simvastatin was defined as subjects who had never been prescribed simvastatin. A multivariable unconditional logistic regression model was used to estimate the odds ratio and 95%CI to explore the correlation between simvastatin use and acute pancreatitis. After adjustment for confounders, multivariable logistic regression analysis revealed that the adjusted odds ratio of acute pancreatitis was 1.3 for subjects with recent use of simvastatin (95%CI 1.02, 1.73), when compared with those with never use of simvastatin. The crude odds ratio decreased to 1.1 for those with remote use of simvastatin (95%CI 0.93, 1.34) but without statistical significance. Recent use of simvastatin is associated with acute pancreatitis. Clinicians should consider the possibility of simvastatin‐associated acute pancreatitis for patients presenting for acute pancreatitis without known cause.</description><identifier>ISSN: 0091-2700</identifier><identifier>EISSN: 1552-4604</identifier><identifier>DOI: 10.1002/jcph.881</identifier><identifier>PMID: 28301063</identifier><language>eng</language><publisher>England: American College of Clinical Pharmacology</publisher><subject>acute pancreatitis ; Adult ; Aged ; Aged, 80 and over ; Anticholesteremic Agents - adverse effects ; Case-Control Studies ; Female ; Health risk assessment ; Humans ; Male ; Middle Aged ; Odds Ratio ; Pancreatitis - chemically induced ; Pancreatitis - epidemiology ; Risk Factors ; simvastatin ; Simvastatin - adverse effects ; Taiwan - epidemiology ; Taiwan National Health Insurance Program ; Young Adult</subject><ispartof>Journal of clinical pharmacology, 2017-07, Vol.57 (7), p.918-923</ispartof><rights>2017, The American College of Clinical Pharmacology</rights><rights>2017 American College of Clinical Pharmacology</rights><rights>2017, The American College of Clinical Pharmacology.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3531-7e438fd82471d8200db33490b942ca7bbf2311b6a5a2dec798662ebc3999c0873</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fjcph.881$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fjcph.881$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,780,784,1417,27924,27925,45574,45575</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28301063$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lin, Chih‐Ming</creatorcontrib><creatorcontrib>Liao, Kuan‐Fu</creatorcontrib><creatorcontrib>Lin, Cheng‐Li</creatorcontrib><creatorcontrib>Lai, Shih‐Wei</creatorcontrib><title>Use of Simvastatin and Risk of Acute Pancreatitis: A Nationwide Case‐Control Study in Taiwan</title><title>Journal of clinical pharmacology</title><addtitle>J Clin Pharmacol</addtitle><description>The correlation between simvastatin use and acute pancreatitis is explored. A case‐control study was conducted to analyze claim data from the Taiwan National Health Insurance Program. The case group comprising a total of 3882 subjects aged 20 to 84 years with their first acute pancreatitis episode occurring between 1998 and 2011 formed the case group, against 3790 randomly selected controls matched for sex, age, comorbidities, and index year of acute pancreatitis diagnosis. Recent use of simvastatin was defined as subjects whose last remaining simvastatin tablet was noted ≤7 days before the date of acute pancreatitis diagnosis. Remote use of simvastatin was defined as subjects whose last remaining 1 tablet for simvastatin was noted >7 days before the date of acute pancreatitis diagnosis. Never use of simvastatin was defined as subjects who had never been prescribed simvastatin. A multivariable unconditional logistic regression model was used to estimate the odds ratio and 95%CI to explore the correlation between simvastatin use and acute pancreatitis. After adjustment for confounders, multivariable logistic regression analysis revealed that the adjusted odds ratio of acute pancreatitis was 1.3 for subjects with recent use of simvastatin (95%CI 1.02, 1.73), when compared with those with never use of simvastatin. The crude odds ratio decreased to 1.1 for those with remote use of simvastatin (95%CI 0.93, 1.34) but without statistical significance. Recent use of simvastatin is associated with acute pancreatitis. Clinicians should consider the possibility of simvastatin‐associated acute pancreatitis for patients presenting for acute pancreatitis without known cause.</description><subject>acute pancreatitis</subject><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Anticholesteremic Agents - adverse effects</subject><subject>Case-Control Studies</subject><subject>Female</subject><subject>Health risk assessment</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Odds Ratio</subject><subject>Pancreatitis - chemically induced</subject><subject>Pancreatitis - epidemiology</subject><subject>Risk Factors</subject><subject>simvastatin</subject><subject>Simvastatin - adverse effects</subject><subject>Taiwan - epidemiology</subject><subject>Taiwan National Health Insurance Program</subject><subject>Young Adult</subject><issn>0091-2700</issn><issn>1552-4604</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpd0c1O3DAUBWCrKoKBIvEEyFI3XRB6befH7m4UtQwIUVRgW8tx7mg8ZJIhdjqaHY_QZ-yT4IihCza2ZX86uvIh5ITBOQPgX5d2vTiXkn0gE5ZlPElzSD-SCYBiCS8ADsih90sAlqcZ2ycHXApgkIsJ-f3gkXZzeudWf4wPJriWmramv5x_HO-ndghIb01re4yPwflvdEpv4rFrN65GWhqP_57_ll0b-q6hd2GotzSG3Bu3Me0nsjc3jcfj3X5EHn58vy9nyfXPi8tyep1YkQmWFJgKOa8lTwsWV4C6EiJVUKmUW1NU1ZwLxqrcZIbXaAsl85xjZYVSyoIsxBH58pq77runAX3QK-ctNo1psRu8ZrKQTAqRj_TzO7rshr6N02mmQPGMS8WjOt2poVphrde9W5l-q99-LoKzV7DpmoC9f2yGDfZ6gaYJC81Aj8XosRgdi4k82XHX4PZ_3Hunr8rb2ehfAP9li60</recordid><startdate>201707</startdate><enddate>201707</enddate><creator>Lin, Chih‐Ming</creator><creator>Liao, Kuan‐Fu</creator><creator>Lin, Cheng‐Li</creator><creator>Lai, Shih‐Wei</creator><general>American College of Clinical Pharmacology</general><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7QP</scope><scope>7QR</scope><scope>7T5</scope><scope>7TK</scope><scope>7TM</scope><scope>8FD</scope><scope>FR3</scope><scope>H94</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>P64</scope><scope>RC3</scope><scope>7X8</scope></search><sort><creationdate>201707</creationdate><title>Use of Simvastatin and Risk of Acute Pancreatitis: A Nationwide Case‐Control Study in Taiwan</title><author>Lin, Chih‐Ming ; Liao, Kuan‐Fu ; Lin, Cheng‐Li ; Lai, Shih‐Wei</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3531-7e438fd82471d8200db33490b942ca7bbf2311b6a5a2dec798662ebc3999c0873</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>acute pancreatitis</topic><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Anticholesteremic Agents - adverse effects</topic><topic>Case-Control Studies</topic><topic>Female</topic><topic>Health risk assessment</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Odds Ratio</topic><topic>Pancreatitis - chemically induced</topic><topic>Pancreatitis - epidemiology</topic><topic>Risk Factors</topic><topic>simvastatin</topic><topic>Simvastatin - adverse effects</topic><topic>Taiwan - epidemiology</topic><topic>Taiwan National Health Insurance Program</topic><topic>Young Adult</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lin, Chih‐Ming</creatorcontrib><creatorcontrib>Liao, Kuan‐Fu</creatorcontrib><creatorcontrib>Lin, Cheng‐Li</creatorcontrib><creatorcontrib>Lai, Shih‐Wei</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Chemoreception Abstracts</collection><collection>Immunology Abstracts</collection><collection>Neurosciences Abstracts</collection><collection>Nucleic Acids Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>Genetics Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of clinical pharmacology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lin, Chih‐Ming</au><au>Liao, Kuan‐Fu</au><au>Lin, Cheng‐Li</au><au>Lai, Shih‐Wei</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Use of Simvastatin and Risk of Acute Pancreatitis: A Nationwide Case‐Control Study in Taiwan</atitle><jtitle>Journal of clinical pharmacology</jtitle><addtitle>J Clin Pharmacol</addtitle><date>2017-07</date><risdate>2017</risdate><volume>57</volume><issue>7</issue><spage>918</spage><epage>923</epage><pages>918-923</pages><issn>0091-2700</issn><eissn>1552-4604</eissn><abstract>The correlation between simvastatin use and acute pancreatitis is explored. A case‐control study was conducted to analyze claim data from the Taiwan National Health Insurance Program. The case group comprising a total of 3882 subjects aged 20 to 84 years with their first acute pancreatitis episode occurring between 1998 and 2011 formed the case group, against 3790 randomly selected controls matched for sex, age, comorbidities, and index year of acute pancreatitis diagnosis. Recent use of simvastatin was defined as subjects whose last remaining simvastatin tablet was noted ≤7 days before the date of acute pancreatitis diagnosis. Remote use of simvastatin was defined as subjects whose last remaining 1 tablet for simvastatin was noted >7 days before the date of acute pancreatitis diagnosis. Never use of simvastatin was defined as subjects who had never been prescribed simvastatin. A multivariable unconditional logistic regression model was used to estimate the odds ratio and 95%CI to explore the correlation between simvastatin use and acute pancreatitis. After adjustment for confounders, multivariable logistic regression analysis revealed that the adjusted odds ratio of acute pancreatitis was 1.3 for subjects with recent use of simvastatin (95%CI 1.02, 1.73), when compared with those with never use of simvastatin. The crude odds ratio decreased to 1.1 for those with remote use of simvastatin (95%CI 0.93, 1.34) but without statistical significance. Recent use of simvastatin is associated with acute pancreatitis. Clinicians should consider the possibility of simvastatin‐associated acute pancreatitis for patients presenting for acute pancreatitis without known cause.</abstract><cop>England</cop><pub>American College of Clinical Pharmacology</pub><pmid>28301063</pmid><doi>10.1002/jcph.881</doi><tpages>6</tpages></addata></record> |
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subjects | acute pancreatitis Adult Aged Aged, 80 and over Anticholesteremic Agents - adverse effects Case-Control Studies Female Health risk assessment Humans Male Middle Aged Odds Ratio Pancreatitis - chemically induced Pancreatitis - epidemiology Risk Factors simvastatin Simvastatin - adverse effects Taiwan - epidemiology Taiwan National Health Insurance Program Young Adult |
title | Use of Simvastatin and Risk of Acute Pancreatitis: A Nationwide Case‐Control Study in Taiwan |
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