Bach2 regulates AID‐mediated immunoglobulin gene conversion and somatic hypermutation in DT40 B cells

The transcription factor Bach2 is required for germinal center formation, somatic hypermutation (SHM), and class‐switch recombination (CSR) of immunoglobulins. SHM and CSR are initiated by activation‐induced cytidine deaminase (AID) which has potential to induce human B cell lymphoma. To understand...

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Veröffentlicht in:	European journal of immunology 2017-06, Vol.47 (6), p.993-1001
Hauptverfasser:	Budzyńska, Paulina M, Kyläniemi, Minna K, Kallonen, Teemu, Soikkeli, Anni I, Nera, Kalle‐Pekka, Lassila, Olli, Alinikula, Jukka
Format:	Artikel
Sprache:	eng
Schlagworte:	Activation-induced cytidine deaminase AICDA AID Animals Antibodies Antibody diversification B cells B-cell lymphoma B-Lymphocytes - immunology B-Lymphocytes - metabolism Bach2 Basic-Leucine Zipper Transcription Factors - metabolism Cell activation Cell Differentiation Chickens Class switching Cytidine deaminase Cytidine Deaminase - metabolism Gene Conversion Gene Expression Regulation Genes, Immunoglobulin Ig somatic hypermutation Immunoglobulin Class Switching Immunoglobulin gene conversion Immunoglobulins Lymphocytes B Lymphoma Recombination Somatic hypermutation Somatic Hypermutation, Immunoglobulin transcription factors Transcription Factors - genetics Transcription Factors - immunology
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