Monoaminergic modulation of GABAergic transmission onto cerebellar globular cells

Cerebellar Purkinje cells (PCs) project their axon collaterals to underneath of the PC layer and make GABAergic synaptic contacts with globular cells, a subgroup of Lugaro cells. GABAergic transmission derived from the PC axon collaterals is so powerful that it could inhibit globular cells and regul...

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Veröffentlicht in:	Neuropharmacology 2017-05, Vol.118, p.79-89
Hauptverfasser:	Hirono, Moritoshi, Nagao, Soichi, Yanagawa, Yuchio, Konishi, Shiro
Format:	Artikel
Sprache:	eng
Schlagworte:	Action Potentials - drug effects Animals Animals, Newborn Axon collateral Bacterial Proteins - genetics Bacterial Proteins - metabolism Biogenic Monoamines - pharmacology Cerebellum Cerebellum - cytology Excitatory Amino Acid Agents - pharmacology GABA GABA Agents - pharmacology GABAergic Neurons - physiology Glutamate Decarboxylase - genetics Glutamate Decarboxylase - metabolism Inhibitory Postsynaptic Potentials - drug effects Luminescent Proteins - genetics Luminescent Proteins - metabolism Mice Mice, Inbred C57BL Mice, Transgenic Models, Biological Noradrenaline Norepinephrine - pharmacology Serotonin Serotonin - pharmacology Sodium Channel Blockers - pharmacology Synaptic modulation Synaptic Transmission - drug effects Tetrodotoxin - pharmacology Vesicular Inhibitory Amino Acid Transport Proteins - genetics Vesicular Inhibitory Amino Acid Transport Proteins - metabolism
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