Par-4 Transcriptionally Regulates Bcl-2 through a WT1-binding Site on the bcl-2 Promoter

Elevated expression levels of the bcl-2 proto-oncogene have been extensively correlated with the appearance of androgen independence in prostate cancer. Although bcl-2 was first cloned as the t(14:18) translocation breakpoint from human follicular B cell lymphoma, the mechanism of overexpression of...

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Veröffentlicht in:	The Journal of biological chemistry 2003-05, Vol.278 (22), p.19995-20005
Hauptverfasser:	Cheema, Sangeeta K., Mishra, Sandip K., Rangnekar, Vivek M., Tari, Ana M., Kumar, Rakesh, Lopez-Berestein, Gabriel
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis - genetics Apoptosis Regulatory Proteins Base Sequence Binding Sites Carrier Proteins - physiology DNA Primers Down-Regulation - drug effects Down-Regulation - physiology G1 Phase - genetics Humans Intracellular Signaling Peptides and Proteins Male Promoter Regions, Genetic Prostatic Neoplasms - genetics Prostatic Neoplasms - metabolism Prostatic Neoplasms - pathology Proto-Oncogene Proteins c-bcl-2 - genetics Proto-Oncogene Proteins c-bcl-2 - metabolism RNA, Messenger - genetics Tretinoin - pharmacology Tumor Cells, Cultured WT1 Proteins - metabolism
Online-Zugang:	Volltext
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