Diagnostic capability of colon capsule endoscopy for advanced colorectal cancer: A pilot study

Background and Aim Colon capsule endoscopy (CCE) is a safe and effective method for detecting lesions in the colon. However, the sensitivity of CCE in detecting advanced colorectal cancer (CRC) has not been sufficiently evaluated. Therefore, the aim of the present study was to assess the sensitivity...

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Veröffentlicht in:Digestive endoscopy 2017-09, Vol.29 (6), p.695-701
Hauptverfasser: Ota, Yumiko, Yamada, Atsuo, Kobayashi, Yuka, Niikura, Ryota, Shimpoh, Takayuki, Narita, Akiko, Yoshida, Shuntaro, Suzuki, Nobumi, Watabe, Hirotsugu, Hirata, Yoshihiro, Ishihara, Soichiro, Sunami, Eiji, Watanabe, Toshiaki, Koike, Kazuhiko
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container_end_page 701
container_issue 6
container_start_page 695
container_title Digestive endoscopy
container_volume 29
creator Ota, Yumiko
Yamada, Atsuo
Kobayashi, Yuka
Niikura, Ryota
Shimpoh, Takayuki
Narita, Akiko
Yoshida, Shuntaro
Suzuki, Nobumi
Watabe, Hirotsugu
Hirata, Yoshihiro
Ishihara, Soichiro
Sunami, Eiji
Watanabe, Toshiaki
Koike, Kazuhiko
description Background and Aim Colon capsule endoscopy (CCE) is a safe and effective method for detecting lesions in the colon. However, the sensitivity of CCE in detecting advanced colorectal cancer (CRC) has not been sufficiently evaluated. Therefore, the aim of the present study was to assess the sensitivity of CCE in detecting advanced CRC. Methods Patients previously diagnosed with advanced CRC by conventional colonoscopy underwent CCE. Primary outcome measure was the sensitivity of CCE in detecting advanced CRC per patient and per lesion. Secondary parameters measured were the sensitivity of CCE in detecting polyps ≥6 mm and ≥10 mm in size in a per‐lesion analysis and the safety of CCE. Results Of the 21 advanced CRC lesions in 20 patients, 17 were detected by CCE. The per‐patient and per‐lesion sensitivities of CCE for detecting advanced CRC lesions were 85% (95% confidence interval [CI]: 62–97%) and 81% (95% CI: 58–95%), respectively. All advanced CRC lesions were diagnosed in the accessible region by CCE while the capsule was still functional. A significant association was found between incomplete CCE and failure to diagnose advanced CRC. No severe adverse events occurred. Conclusion The diagnostic capability of CCE in detecting advanced CRC was limited in cases of procedure incompletion. Refining procedures to increase CCE procedure completion rates are required to enhance CRC detection.
doi_str_mv 10.1111/den.12862
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However, the sensitivity of CCE in detecting advanced colorectal cancer (CRC) has not been sufficiently evaluated. Therefore, the aim of the present study was to assess the sensitivity of CCE in detecting advanced CRC. Methods Patients previously diagnosed with advanced CRC by conventional colonoscopy underwent CCE. Primary outcome measure was the sensitivity of CCE in detecting advanced CRC per patient and per lesion. Secondary parameters measured were the sensitivity of CCE in detecting polyps ≥6 mm and ≥10 mm in size in a per‐lesion analysis and the safety of CCE. Results Of the 21 advanced CRC lesions in 20 patients, 17 were detected by CCE. The per‐patient and per‐lesion sensitivities of CCE for detecting advanced CRC lesions were 85% (95% confidence interval [CI]: 62–97%) and 81% (95% CI: 58–95%), respectively. All advanced CRC lesions were diagnosed in the accessible region by CCE while the capsule was still functional. A significant association was found between incomplete CCE and failure to diagnose advanced CRC. No severe adverse events occurred. Conclusion The diagnostic capability of CCE in detecting advanced CRC was limited in cases of procedure incompletion. Refining procedures to increase CCE procedure completion rates are required to enhance CRC detection.</description><identifier>ISSN: 0915-5635</identifier><identifier>EISSN: 1443-1661</identifier><identifier>DOI: 10.1111/den.12862</identifier><identifier>PMID: 28295697</identifier><language>eng</language><publisher>Australia</publisher><subject>Adult ; Aged ; capsule endoscopy ; Capsule Endoscopy - methods ; Cohort Studies ; colonoscopy ; Colonoscopy - methods ; colorectal cancer ; Colorectal Neoplasms - diagnosis ; Colorectal Neoplasms - pathology ; Colorectal Neoplasms - surgery ; Confidence Intervals ; diagnosis ; Female ; Follow-Up Studies ; Humans ; Male ; Middle Aged ; Neoplasm Invasiveness - pathology ; Neoplasm Staging ; Pilot Projects ; Retrospective Studies ; Risk Assessment ; sensitivity ; Sensitivity and Specificity</subject><ispartof>Digestive endoscopy, 2017-09, Vol.29 (6), p.695-701</ispartof><rights>2017 Japan Gastroenterological Endoscopy Society</rights><rights>2017 Japan Gastroenterological Endoscopy Society.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3492-7fa3f084873a1096297d8009f5a68a93d84cd3b9678941c33404101909dc32d03</citedby><cites>FETCH-LOGICAL-c3492-7fa3f084873a1096297d8009f5a68a93d84cd3b9678941c33404101909dc32d03</cites><orcidid>0000-0001-6497-3264</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fden.12862$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fden.12862$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28295697$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ota, Yumiko</creatorcontrib><creatorcontrib>Yamada, Atsuo</creatorcontrib><creatorcontrib>Kobayashi, Yuka</creatorcontrib><creatorcontrib>Niikura, Ryota</creatorcontrib><creatorcontrib>Shimpoh, Takayuki</creatorcontrib><creatorcontrib>Narita, Akiko</creatorcontrib><creatorcontrib>Yoshida, Shuntaro</creatorcontrib><creatorcontrib>Suzuki, Nobumi</creatorcontrib><creatorcontrib>Watabe, Hirotsugu</creatorcontrib><creatorcontrib>Hirata, Yoshihiro</creatorcontrib><creatorcontrib>Ishihara, Soichiro</creatorcontrib><creatorcontrib>Sunami, Eiji</creatorcontrib><creatorcontrib>Watanabe, Toshiaki</creatorcontrib><creatorcontrib>Koike, Kazuhiko</creatorcontrib><title>Diagnostic capability of colon capsule endoscopy for advanced colorectal cancer: A pilot study</title><title>Digestive endoscopy</title><addtitle>Dig Endosc</addtitle><description>Background and Aim Colon capsule endoscopy (CCE) is a safe and effective method for detecting lesions in the colon. However, the sensitivity of CCE in detecting advanced colorectal cancer (CRC) has not been sufficiently evaluated. Therefore, the aim of the present study was to assess the sensitivity of CCE in detecting advanced CRC. Methods Patients previously diagnosed with advanced CRC by conventional colonoscopy underwent CCE. Primary outcome measure was the sensitivity of CCE in detecting advanced CRC per patient and per lesion. Secondary parameters measured were the sensitivity of CCE in detecting polyps ≥6 mm and ≥10 mm in size in a per‐lesion analysis and the safety of CCE. Results Of the 21 advanced CRC lesions in 20 patients, 17 were detected by CCE. The per‐patient and per‐lesion sensitivities of CCE for detecting advanced CRC lesions were 85% (95% confidence interval [CI]: 62–97%) and 81% (95% CI: 58–95%), respectively. All advanced CRC lesions were diagnosed in the accessible region by CCE while the capsule was still functional. A significant association was found between incomplete CCE and failure to diagnose advanced CRC. No severe adverse events occurred. Conclusion The diagnostic capability of CCE in detecting advanced CRC was limited in cases of procedure incompletion. 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Yamada, Atsuo ; Kobayashi, Yuka ; Niikura, Ryota ; Shimpoh, Takayuki ; Narita, Akiko ; Yoshida, Shuntaro ; Suzuki, Nobumi ; Watabe, Hirotsugu ; Hirata, Yoshihiro ; Ishihara, Soichiro ; Sunami, Eiji ; Watanabe, Toshiaki ; Koike, Kazuhiko</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3492-7fa3f084873a1096297d8009f5a68a93d84cd3b9678941c33404101909dc32d03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Adult</topic><topic>Aged</topic><topic>capsule endoscopy</topic><topic>Capsule Endoscopy - methods</topic><topic>Cohort Studies</topic><topic>colonoscopy</topic><topic>Colonoscopy - methods</topic><topic>colorectal cancer</topic><topic>Colorectal Neoplasms - diagnosis</topic><topic>Colorectal Neoplasms - pathology</topic><topic>Colorectal Neoplasms - surgery</topic><topic>Confidence Intervals</topic><topic>diagnosis</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Neoplasm Invasiveness - pathology</topic><topic>Neoplasm Staging</topic><topic>Pilot Projects</topic><topic>Retrospective Studies</topic><topic>Risk Assessment</topic><topic>sensitivity</topic><topic>Sensitivity and Specificity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ota, Yumiko</creatorcontrib><creatorcontrib>Yamada, Atsuo</creatorcontrib><creatorcontrib>Kobayashi, Yuka</creatorcontrib><creatorcontrib>Niikura, Ryota</creatorcontrib><creatorcontrib>Shimpoh, Takayuki</creatorcontrib><creatorcontrib>Narita, Akiko</creatorcontrib><creatorcontrib>Yoshida, Shuntaro</creatorcontrib><creatorcontrib>Suzuki, Nobumi</creatorcontrib><creatorcontrib>Watabe, Hirotsugu</creatorcontrib><creatorcontrib>Hirata, Yoshihiro</creatorcontrib><creatorcontrib>Ishihara, Soichiro</creatorcontrib><creatorcontrib>Sunami, Eiji</creatorcontrib><creatorcontrib>Watanabe, Toshiaki</creatorcontrib><creatorcontrib>Koike, Kazuhiko</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Digestive endoscopy</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ota, Yumiko</au><au>Yamada, Atsuo</au><au>Kobayashi, Yuka</au><au>Niikura, Ryota</au><au>Shimpoh, Takayuki</au><au>Narita, Akiko</au><au>Yoshida, Shuntaro</au><au>Suzuki, Nobumi</au><au>Watabe, Hirotsugu</au><au>Hirata, Yoshihiro</au><au>Ishihara, Soichiro</au><au>Sunami, Eiji</au><au>Watanabe, Toshiaki</au><au>Koike, Kazuhiko</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Diagnostic capability of colon capsule endoscopy for advanced colorectal cancer: A pilot study</atitle><jtitle>Digestive endoscopy</jtitle><addtitle>Dig Endosc</addtitle><date>2017-09</date><risdate>2017</risdate><volume>29</volume><issue>6</issue><spage>695</spage><epage>701</epage><pages>695-701</pages><issn>0915-5635</issn><eissn>1443-1661</eissn><abstract>Background and Aim Colon capsule endoscopy (CCE) is a safe and effective method for detecting lesions in the colon. However, the sensitivity of CCE in detecting advanced colorectal cancer (CRC) has not been sufficiently evaluated. Therefore, the aim of the present study was to assess the sensitivity of CCE in detecting advanced CRC. Methods Patients previously diagnosed with advanced CRC by conventional colonoscopy underwent CCE. Primary outcome measure was the sensitivity of CCE in detecting advanced CRC per patient and per lesion. Secondary parameters measured were the sensitivity of CCE in detecting polyps ≥6 mm and ≥10 mm in size in a per‐lesion analysis and the safety of CCE. Results Of the 21 advanced CRC lesions in 20 patients, 17 were detected by CCE. The per‐patient and per‐lesion sensitivities of CCE for detecting advanced CRC lesions were 85% (95% confidence interval [CI]: 62–97%) and 81% (95% CI: 58–95%), respectively. All advanced CRC lesions were diagnosed in the accessible region by CCE while the capsule was still functional. A significant association was found between incomplete CCE and failure to diagnose advanced CRC. No severe adverse events occurred. Conclusion The diagnostic capability of CCE in detecting advanced CRC was limited in cases of procedure incompletion. Refining procedures to increase CCE procedure completion rates are required to enhance CRC detection.</abstract><cop>Australia</cop><pmid>28295697</pmid><doi>10.1111/den.12862</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0001-6497-3264</orcidid></addata></record>
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source MEDLINE; Wiley Online Library Journals Frontfile Complete
subjects Adult
Aged
capsule endoscopy
Capsule Endoscopy - methods
Cohort Studies
colonoscopy
Colonoscopy - methods
colorectal cancer
Colorectal Neoplasms - diagnosis
Colorectal Neoplasms - pathology
Colorectal Neoplasms - surgery
Confidence Intervals
diagnosis
Female
Follow-Up Studies
Humans
Male
Middle Aged
Neoplasm Invasiveness - pathology
Neoplasm Staging
Pilot Projects
Retrospective Studies
Risk Assessment
sensitivity
Sensitivity and Specificity
title Diagnostic capability of colon capsule endoscopy for advanced colorectal cancer: A pilot study
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