Diagnostic capability of colon capsule endoscopy for advanced colorectal cancer: A pilot study
Background and Aim Colon capsule endoscopy (CCE) is a safe and effective method for detecting lesions in the colon. However, the sensitivity of CCE in detecting advanced colorectal cancer (CRC) has not been sufficiently evaluated. Therefore, the aim of the present study was to assess the sensitivity...
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Veröffentlicht in: | Digestive endoscopy 2017-09, Vol.29 (6), p.695-701 |
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creator | Ota, Yumiko Yamada, Atsuo Kobayashi, Yuka Niikura, Ryota Shimpoh, Takayuki Narita, Akiko Yoshida, Shuntaro Suzuki, Nobumi Watabe, Hirotsugu Hirata, Yoshihiro Ishihara, Soichiro Sunami, Eiji Watanabe, Toshiaki Koike, Kazuhiko |
description | Background and Aim
Colon capsule endoscopy (CCE) is a safe and effective method for detecting lesions in the colon. However, the sensitivity of CCE in detecting advanced colorectal cancer (CRC) has not been sufficiently evaluated. Therefore, the aim of the present study was to assess the sensitivity of CCE in detecting advanced CRC.
Methods
Patients previously diagnosed with advanced CRC by conventional colonoscopy underwent CCE. Primary outcome measure was the sensitivity of CCE in detecting advanced CRC per patient and per lesion. Secondary parameters measured were the sensitivity of CCE in detecting polyps ≥6 mm and ≥10 mm in size in a per‐lesion analysis and the safety of CCE.
Results
Of the 21 advanced CRC lesions in 20 patients, 17 were detected by CCE. The per‐patient and per‐lesion sensitivities of CCE for detecting advanced CRC lesions were 85% (95% confidence interval [CI]: 62–97%) and 81% (95% CI: 58–95%), respectively. All advanced CRC lesions were diagnosed in the accessible region by CCE while the capsule was still functional. A significant association was found between incomplete CCE and failure to diagnose advanced CRC. No severe adverse events occurred.
Conclusion
The diagnostic capability of CCE in detecting advanced CRC was limited in cases of procedure incompletion. Refining procedures to increase CCE procedure completion rates are required to enhance CRC detection. |
doi_str_mv | 10.1111/den.12862 |
format | Article |
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Colon capsule endoscopy (CCE) is a safe and effective method for detecting lesions in the colon. However, the sensitivity of CCE in detecting advanced colorectal cancer (CRC) has not been sufficiently evaluated. Therefore, the aim of the present study was to assess the sensitivity of CCE in detecting advanced CRC.
Methods
Patients previously diagnosed with advanced CRC by conventional colonoscopy underwent CCE. Primary outcome measure was the sensitivity of CCE in detecting advanced CRC per patient and per lesion. Secondary parameters measured were the sensitivity of CCE in detecting polyps ≥6 mm and ≥10 mm in size in a per‐lesion analysis and the safety of CCE.
Results
Of the 21 advanced CRC lesions in 20 patients, 17 were detected by CCE. The per‐patient and per‐lesion sensitivities of CCE for detecting advanced CRC lesions were 85% (95% confidence interval [CI]: 62–97%) and 81% (95% CI: 58–95%), respectively. All advanced CRC lesions were diagnosed in the accessible region by CCE while the capsule was still functional. A significant association was found between incomplete CCE and failure to diagnose advanced CRC. No severe adverse events occurred.
Conclusion
The diagnostic capability of CCE in detecting advanced CRC was limited in cases of procedure incompletion. Refining procedures to increase CCE procedure completion rates are required to enhance CRC detection.</description><identifier>ISSN: 0915-5635</identifier><identifier>EISSN: 1443-1661</identifier><identifier>DOI: 10.1111/den.12862</identifier><identifier>PMID: 28295697</identifier><language>eng</language><publisher>Australia</publisher><subject>Adult ; Aged ; capsule endoscopy ; Capsule Endoscopy - methods ; Cohort Studies ; colonoscopy ; Colonoscopy - methods ; colorectal cancer ; Colorectal Neoplasms - diagnosis ; Colorectal Neoplasms - pathology ; Colorectal Neoplasms - surgery ; Confidence Intervals ; diagnosis ; Female ; Follow-Up Studies ; Humans ; Male ; Middle Aged ; Neoplasm Invasiveness - pathology ; Neoplasm Staging ; Pilot Projects ; Retrospective Studies ; Risk Assessment ; sensitivity ; Sensitivity and Specificity</subject><ispartof>Digestive endoscopy, 2017-09, Vol.29 (6), p.695-701</ispartof><rights>2017 Japan Gastroenterological Endoscopy Society</rights><rights>2017 Japan Gastroenterological Endoscopy Society.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3492-7fa3f084873a1096297d8009f5a68a93d84cd3b9678941c33404101909dc32d03</citedby><cites>FETCH-LOGICAL-c3492-7fa3f084873a1096297d8009f5a68a93d84cd3b9678941c33404101909dc32d03</cites><orcidid>0000-0001-6497-3264</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fden.12862$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fden.12862$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28295697$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Ota, Yumiko</creatorcontrib><creatorcontrib>Yamada, Atsuo</creatorcontrib><creatorcontrib>Kobayashi, Yuka</creatorcontrib><creatorcontrib>Niikura, Ryota</creatorcontrib><creatorcontrib>Shimpoh, Takayuki</creatorcontrib><creatorcontrib>Narita, Akiko</creatorcontrib><creatorcontrib>Yoshida, Shuntaro</creatorcontrib><creatorcontrib>Suzuki, Nobumi</creatorcontrib><creatorcontrib>Watabe, Hirotsugu</creatorcontrib><creatorcontrib>Hirata, Yoshihiro</creatorcontrib><creatorcontrib>Ishihara, Soichiro</creatorcontrib><creatorcontrib>Sunami, Eiji</creatorcontrib><creatorcontrib>Watanabe, Toshiaki</creatorcontrib><creatorcontrib>Koike, Kazuhiko</creatorcontrib><title>Diagnostic capability of colon capsule endoscopy for advanced colorectal cancer: A pilot study</title><title>Digestive endoscopy</title><addtitle>Dig Endosc</addtitle><description>Background and Aim
Colon capsule endoscopy (CCE) is a safe and effective method for detecting lesions in the colon. However, the sensitivity of CCE in detecting advanced colorectal cancer (CRC) has not been sufficiently evaluated. Therefore, the aim of the present study was to assess the sensitivity of CCE in detecting advanced CRC.
Methods
Patients previously diagnosed with advanced CRC by conventional colonoscopy underwent CCE. Primary outcome measure was the sensitivity of CCE in detecting advanced CRC per patient and per lesion. Secondary parameters measured were the sensitivity of CCE in detecting polyps ≥6 mm and ≥10 mm in size in a per‐lesion analysis and the safety of CCE.
Results
Of the 21 advanced CRC lesions in 20 patients, 17 were detected by CCE. The per‐patient and per‐lesion sensitivities of CCE for detecting advanced CRC lesions were 85% (95% confidence interval [CI]: 62–97%) and 81% (95% CI: 58–95%), respectively. All advanced CRC lesions were diagnosed in the accessible region by CCE while the capsule was still functional. A significant association was found between incomplete CCE and failure to diagnose advanced CRC. No severe adverse events occurred.
Conclusion
The diagnostic capability of CCE in detecting advanced CRC was limited in cases of procedure incompletion. Refining procedures to increase CCE procedure completion rates are required to enhance CRC detection.</description><subject>Adult</subject><subject>Aged</subject><subject>capsule endoscopy</subject><subject>Capsule Endoscopy - methods</subject><subject>Cohort Studies</subject><subject>colonoscopy</subject><subject>Colonoscopy - methods</subject><subject>colorectal cancer</subject><subject>Colorectal Neoplasms - diagnosis</subject><subject>Colorectal Neoplasms - pathology</subject><subject>Colorectal Neoplasms - surgery</subject><subject>Confidence Intervals</subject><subject>diagnosis</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Neoplasm Invasiveness - pathology</subject><subject>Neoplasm Staging</subject><subject>Pilot Projects</subject><subject>Retrospective Studies</subject><subject>Risk Assessment</subject><subject>sensitivity</subject><subject>Sensitivity and Specificity</subject><issn>0915-5635</issn><issn>1443-1661</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kL1OwzAURi0EoqUw8ALIIwxp7dhxbLaqLT9SBQusWK7toCA3DnYCytuTNoWNu1zp09EZDgCXGE1xfzNjqylOOUuPwBhTShLMGD4GYyRwlmSMZCNwFuMHQjgVlJ6CUcpTkTGRj8HbslTvlY9NqaFWtdqUrmw66AuovfPVbouts9BWxkft6w4WPkBlvlSlrdlDwepGuZ7sl3AL57AunW9gbFrTnYOTQrloLw5_Al7vVi-Lh2T9fP-4mK8TTahIk7xQpECc8pwojARLRW44QqLIFONKEMOpNmQjWM4FxZoQiihGWCBhNEkNIhNwPXjr4D9bGxu5LaO2zqnK-jZKzPOcZxlDrEdvBlQHH2OwhaxDuVWhkxjJXU7Z55T7nD17ddC2m601f-Rvvx6YDcB36Wz3v0kuV0-D8geOin3K</recordid><startdate>201709</startdate><enddate>201709</enddate><creator>Ota, Yumiko</creator><creator>Yamada, Atsuo</creator><creator>Kobayashi, Yuka</creator><creator>Niikura, Ryota</creator><creator>Shimpoh, Takayuki</creator><creator>Narita, Akiko</creator><creator>Yoshida, Shuntaro</creator><creator>Suzuki, Nobumi</creator><creator>Watabe, Hirotsugu</creator><creator>Hirata, Yoshihiro</creator><creator>Ishihara, Soichiro</creator><creator>Sunami, Eiji</creator><creator>Watanabe, Toshiaki</creator><creator>Koike, Kazuhiko</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-6497-3264</orcidid></search><sort><creationdate>201709</creationdate><title>Diagnostic capability of colon capsule endoscopy for advanced colorectal cancer: A pilot study</title><author>Ota, Yumiko ; Yamada, Atsuo ; Kobayashi, Yuka ; Niikura, Ryota ; Shimpoh, Takayuki ; Narita, Akiko ; Yoshida, Shuntaro ; Suzuki, Nobumi ; Watabe, Hirotsugu ; Hirata, Yoshihiro ; Ishihara, Soichiro ; Sunami, Eiji ; Watanabe, Toshiaki ; Koike, Kazuhiko</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3492-7fa3f084873a1096297d8009f5a68a93d84cd3b9678941c33404101909dc32d03</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Adult</topic><topic>Aged</topic><topic>capsule endoscopy</topic><topic>Capsule Endoscopy - methods</topic><topic>Cohort Studies</topic><topic>colonoscopy</topic><topic>Colonoscopy - methods</topic><topic>colorectal cancer</topic><topic>Colorectal Neoplasms - diagnosis</topic><topic>Colorectal Neoplasms - pathology</topic><topic>Colorectal Neoplasms - surgery</topic><topic>Confidence Intervals</topic><topic>diagnosis</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Neoplasm Invasiveness - pathology</topic><topic>Neoplasm Staging</topic><topic>Pilot Projects</topic><topic>Retrospective Studies</topic><topic>Risk Assessment</topic><topic>sensitivity</topic><topic>Sensitivity and Specificity</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Ota, Yumiko</creatorcontrib><creatorcontrib>Yamada, Atsuo</creatorcontrib><creatorcontrib>Kobayashi, Yuka</creatorcontrib><creatorcontrib>Niikura, Ryota</creatorcontrib><creatorcontrib>Shimpoh, Takayuki</creatorcontrib><creatorcontrib>Narita, Akiko</creatorcontrib><creatorcontrib>Yoshida, Shuntaro</creatorcontrib><creatorcontrib>Suzuki, Nobumi</creatorcontrib><creatorcontrib>Watabe, Hirotsugu</creatorcontrib><creatorcontrib>Hirata, Yoshihiro</creatorcontrib><creatorcontrib>Ishihara, Soichiro</creatorcontrib><creatorcontrib>Sunami, Eiji</creatorcontrib><creatorcontrib>Watanabe, Toshiaki</creatorcontrib><creatorcontrib>Koike, Kazuhiko</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Digestive endoscopy</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Ota, Yumiko</au><au>Yamada, Atsuo</au><au>Kobayashi, Yuka</au><au>Niikura, Ryota</au><au>Shimpoh, Takayuki</au><au>Narita, Akiko</au><au>Yoshida, Shuntaro</au><au>Suzuki, Nobumi</au><au>Watabe, Hirotsugu</au><au>Hirata, Yoshihiro</au><au>Ishihara, Soichiro</au><au>Sunami, Eiji</au><au>Watanabe, Toshiaki</au><au>Koike, Kazuhiko</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Diagnostic capability of colon capsule endoscopy for advanced colorectal cancer: A pilot study</atitle><jtitle>Digestive endoscopy</jtitle><addtitle>Dig Endosc</addtitle><date>2017-09</date><risdate>2017</risdate><volume>29</volume><issue>6</issue><spage>695</spage><epage>701</epage><pages>695-701</pages><issn>0915-5635</issn><eissn>1443-1661</eissn><abstract>Background and Aim
Colon capsule endoscopy (CCE) is a safe and effective method for detecting lesions in the colon. However, the sensitivity of CCE in detecting advanced colorectal cancer (CRC) has not been sufficiently evaluated. Therefore, the aim of the present study was to assess the sensitivity of CCE in detecting advanced CRC.
Methods
Patients previously diagnosed with advanced CRC by conventional colonoscopy underwent CCE. Primary outcome measure was the sensitivity of CCE in detecting advanced CRC per patient and per lesion. Secondary parameters measured were the sensitivity of CCE in detecting polyps ≥6 mm and ≥10 mm in size in a per‐lesion analysis and the safety of CCE.
Results
Of the 21 advanced CRC lesions in 20 patients, 17 were detected by CCE. The per‐patient and per‐lesion sensitivities of CCE for detecting advanced CRC lesions were 85% (95% confidence interval [CI]: 62–97%) and 81% (95% CI: 58–95%), respectively. All advanced CRC lesions were diagnosed in the accessible region by CCE while the capsule was still functional. A significant association was found between incomplete CCE and failure to diagnose advanced CRC. No severe adverse events occurred.
Conclusion
The diagnostic capability of CCE in detecting advanced CRC was limited in cases of procedure incompletion. Refining procedures to increase CCE procedure completion rates are required to enhance CRC detection.</abstract><cop>Australia</cop><pmid>28295697</pmid><doi>10.1111/den.12862</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0001-6497-3264</orcidid></addata></record> |
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subjects | Adult Aged capsule endoscopy Capsule Endoscopy - methods Cohort Studies colonoscopy Colonoscopy - methods colorectal cancer Colorectal Neoplasms - diagnosis Colorectal Neoplasms - pathology Colorectal Neoplasms - surgery Confidence Intervals diagnosis Female Follow-Up Studies Humans Male Middle Aged Neoplasm Invasiveness - pathology Neoplasm Staging Pilot Projects Retrospective Studies Risk Assessment sensitivity Sensitivity and Specificity |
title | Diagnostic capability of colon capsule endoscopy for advanced colorectal cancer: A pilot study |
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