Biosensor‐Enabled Directed Evolution to Improve Muconic Acid Production in Saccharomyces cerevisiae

Muconic acid is a valuable platform chemical with potential applications in the production of polymers such as nylon and polyethylene terephthalate (PET). The conjugate base, muconate, has been previously biosynthesized in the bacterial host Escherichia coli. Likewise, previous significant pathway e...

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Veröffentlicht in:	Biotechnology journal 2017-10, Vol.12 (10), p.n/a
Hauptverfasser:	Leavitt, John M., Wagner, James M., Tu, Cuong C., Tong, Alice, Liu, Yanyi, Alper, Hal S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Amino Acids, Aromatic - metabolism aromatic amino acids Bioreactors Biosensing Techniques - instrumentation biosensor Escherichia coli - metabolism Ethyl Methanesulfonate Fermentation Metabolic Engineering - methods muconic acid Mutagenesis Saccharomyces cerevisiae Saccharomyces cerevisiae - metabolism Saccharomyces cerevisiae Proteins Shikimic Acid - metabolism Sorbic Acid - analogs & derivatives Sorbic Acid - analysis Sorbic Acid - metabolism Tyrosine - metabolism
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