Flavonoids from Potentilla parvifolia Fisch. and Their Neuroprotective Effects in Human Neuroblastoma SH‐SY5Y Cells in vitro
Potentilla parvifolia Fisch. (Rosaceae) is a traditional medicinal plant in P. R. China. In this study, seven flavonoids, ayanin (1), tricin (2), quercetin (3), tiliroside (4), miquelianin (5), isoquercitrin (6), and astragalin (7), were separated and purified from ethyl acetate extractive fractions...
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| Veröffentlicht in: | Chemistry & biodiversity 2017-06, Vol.14 (6), p.n/a |
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| creator | Yuan, Zhenzhen Luan, Guangxiang Wang, Zhenhua Hao, Xueyan Li, Ji Suo, Yourui Li, Gang Wang, Honglun |
| description | Potentilla parvifolia Fisch. (Rosaceae) is a traditional medicinal plant in P. R. China. In this study, seven flavonoids, ayanin (1), tricin (2), quercetin (3), tiliroside (4), miquelianin (5), isoquercitrin (6), and astragalin (7), were separated and purified from ethyl acetate extractive fractions from ethanol extracts of P. parvifolia using a combination of sevaral chromatographic methods. The human neuroblastoma SH‐SY5Y cells were differentiated with all trans‐retinoic acid and treated with okadaic acid to induce tau protein phosphorylation and synaptic atrophy, which could establish an Alzheimer's disease cell model. The neuroprotective effects of these flavonoids in cellular were evaluated in vitro by this cell model. Results from the Western blot and morphology analysis suggested that compounds 3 and 4 had the better neuroprotective effects. |
| doi_str_mv | 10.1002/cbdv.201600487 |
| format | Article |
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(Rosaceae) is a traditional medicinal plant in P. R. China. In this study, seven flavonoids, ayanin (1), tricin (2), quercetin (3), tiliroside (4), miquelianin (5), isoquercitrin (6), and astragalin (7), were separated and purified from ethyl acetate extractive fractions from ethanol extracts of P. parvifolia using a combination of sevaral chromatographic methods. The human neuroblastoma SH‐SY5Y cells were differentiated with all trans‐retinoic acid and treated with okadaic acid to induce tau protein phosphorylation and synaptic atrophy, which could establish an Alzheimer's disease cell model. The neuroprotective effects of these flavonoids in cellular were evaluated in vitro by this cell model. Results from the Western blot and morphology analysis suggested that compounds 3 and 4 had the better neuroprotective effects.</description><identifier>ISSN: 1612-1872</identifier><identifier>EISSN: 1612-1880</identifier><identifier>DOI: 10.1002/cbdv.201600487</identifier><identifier>PMID: 28294523</identifier><language>eng</language><publisher>Switzerland</publisher><subject>Alzheimer Disease - chemically induced ; Alzheimer Disease - drug therapy ; Alzheimer Disease - pathology ; Cell Differentiation ; Cell Line, Tumor ; Flavonoids ; Flavonoids - isolation & purification ; Flavonoids - pharmacology ; Humans ; Neuroblastoma - drug therapy ; Neuroblastoma - pathology ; Neuroprotective Agents - isolation & purification ; Neuroprotective Agents - pharmacology ; Neuroprotective effects ; Phosphorylation ; Plant Extracts - chemistry ; Potentilla - chemistry ; Potentilla parvifolia Fisch ; SH‐SY5Y cells ; Tau phosphorylation ; tau Proteins - metabolism</subject><ispartof>Chemistry & biodiversity, 2017-06, Vol.14 (6), p.n/a</ispartof><rights>2017 Wiley‐VHCA AG, Zurich, Switzerland</rights><rights>2017 Wiley-VHCA AG, Zurich, Switzerland.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fcbdv.201600487$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fcbdv.201600487$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,778,782,1414,27907,27908,45557,45558</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28294523$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Yuan, Zhenzhen</creatorcontrib><creatorcontrib>Luan, Guangxiang</creatorcontrib><creatorcontrib>Wang, Zhenhua</creatorcontrib><creatorcontrib>Hao, Xueyan</creatorcontrib><creatorcontrib>Li, Ji</creatorcontrib><creatorcontrib>Suo, Yourui</creatorcontrib><creatorcontrib>Li, Gang</creatorcontrib><creatorcontrib>Wang, Honglun</creatorcontrib><title>Flavonoids from Potentilla parvifolia Fisch. and Their Neuroprotective Effects in Human Neuroblastoma SH‐SY5Y Cells in vitro</title><title>Chemistry & biodiversity</title><addtitle>Chem Biodivers</addtitle><description>Potentilla parvifolia Fisch. (Rosaceae) is a traditional medicinal plant in P. R. China. In this study, seven flavonoids, ayanin (1), tricin (2), quercetin (3), tiliroside (4), miquelianin (5), isoquercitrin (6), and astragalin (7), were separated and purified from ethyl acetate extractive fractions from ethanol extracts of P. parvifolia using a combination of sevaral chromatographic methods. The human neuroblastoma SH‐SY5Y cells were differentiated with all trans‐retinoic acid and treated with okadaic acid to induce tau protein phosphorylation and synaptic atrophy, which could establish an Alzheimer's disease cell model. The neuroprotective effects of these flavonoids in cellular were evaluated in vitro by this cell model. Results from the Western blot and morphology analysis suggested that compounds 3 and 4 had the better neuroprotective effects.</description><subject>Alzheimer Disease - chemically induced</subject><subject>Alzheimer Disease - drug therapy</subject><subject>Alzheimer Disease - pathology</subject><subject>Cell Differentiation</subject><subject>Cell Line, Tumor</subject><subject>Flavonoids</subject><subject>Flavonoids - isolation & purification</subject><subject>Flavonoids - pharmacology</subject><subject>Humans</subject><subject>Neuroblastoma - drug therapy</subject><subject>Neuroblastoma - pathology</subject><subject>Neuroprotective Agents - isolation & purification</subject><subject>Neuroprotective Agents - pharmacology</subject><subject>Neuroprotective effects</subject><subject>Phosphorylation</subject><subject>Plant Extracts - chemistry</subject><subject>Potentilla - chemistry</subject><subject>Potentilla parvifolia Fisch</subject><subject>SH‐SY5Y cells</subject><subject>Tau phosphorylation</subject><subject>tau Proteins - metabolism</subject><issn>1612-1872</issn><issn>1612-1880</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNo9kbFOwzAURS0EolBYGZFHlhTbSZ1khNBSpAqQWpA6RXbsqEZOHOIkqAviE_hGvgSXlgyW37WPnt67F4ALjEYYIXKdcdGNCMIUoSAKD8AJpph4OIrQYV-HZABOrX1zvHuPjsGARCQOxsQ_AZ9TzTpTGiUszGtTwGfTyLJRWjNYsbpTudGKwamy2XoEWSngci1VDR9lW5uqdnDWqE7CSZ67ykJVwllbsHIHcM1sYwoGF7Ofr-_FaryCidT6D-tUU5szcJQzbeX5_h6Cl-lkmcy8-dP9Q3Iz9ypCcejRUBBKQix87gdCSspwnOE8ltwdRCmP84BKjtE4zihHhKKYM586RYLQF9gfgqtdXzfyeyttkxZuIzcKK6VpbepMCiNnCA4derlHW15IkVa1Kli9Sf89c0C8Az6Ulpv-H6N0m0i6TSTtE0mT27vXXvm_TdWA9Q</recordid><startdate>201706</startdate><enddate>201706</enddate><creator>Yuan, Zhenzhen</creator><creator>Luan, Guangxiang</creator><creator>Wang, Zhenhua</creator><creator>Hao, Xueyan</creator><creator>Li, Ji</creator><creator>Suo, Yourui</creator><creator>Li, Gang</creator><creator>Wang, Honglun</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7X8</scope></search><sort><creationdate>201706</creationdate><title>Flavonoids from Potentilla parvifolia Fisch. and Their Neuroprotective Effects in Human Neuroblastoma SH‐SY5Y Cells in vitro</title><author>Yuan, Zhenzhen ; 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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Alzheimer Disease - chemically induced Alzheimer Disease - drug therapy Alzheimer Disease - pathology Cell Differentiation Cell Line, Tumor Flavonoids Flavonoids - isolation & purification Flavonoids - pharmacology Humans Neuroblastoma - drug therapy Neuroblastoma - pathology Neuroprotective Agents - isolation & purification Neuroprotective Agents - pharmacology Neuroprotective effects Phosphorylation Plant Extracts - chemistry Potentilla - chemistry Potentilla parvifolia Fisch SH‐SY5Y cells Tau phosphorylation tau Proteins - metabolism |
| title | Flavonoids from Potentilla parvifolia Fisch. and Their Neuroprotective Effects in Human Neuroblastoma SH‐SY5Y Cells in vitro |
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