Intracellular acidification increases adenosine transport in human umbilical vein endothelial cells

Abstract Introduction Adenosine is taken up via human equilibrative nucleoside transporters 1 (hENT1) and 2 (hENT2) at a physiological extracellular pH (pHo ∼7.4) in human umbilical vein endothelial cells (HUVECs). Acidic pHo increases the uptake of adenosine and 5-hydroxytryptamine (5HT) via hENT4...

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Veröffentlicht in:	Placenta (Eastbourne) 2017-03, Vol.51, p.10-17
Hauptverfasser:	Celis, Natalia, Araos, Joaquín, Sanhueza, Carlos, Toledo, Fernando, Beltrán, Ana R, Pardo, Fabián, Leiva, Andrea, Ramírez, Marco A, Sobrevia, Luis
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenosine - metabolism Adenosine - pharmacology Adenosine transport Biological Transport Endothelium ENT transporters Equilibrative Nucleoside Transporter 1 - metabolism Equilibrative-Nucleoside Transporter 2 - metabolism Female Foetus Human Umbilical Vein Endothelial Cells - drug effects Human Umbilical Vein Endothelial Cells - metabolism Humans Hydrogen-Ion Concentration Internal Medicine Intracellular pH Obstetrics and Gynecology Pregnancy Thioinosine - analogs & derivatives Thioinosine - pharmacology
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