Influence of low-level laser therapy on the healing of human bone maxillofacial defects: A systematic review
This systematic review evaluates the effectiveness of low-level laser therapy (LLLT) to enhance maxillofacial area bone repair. A comprehensive search of studies published up to February 2017 and listed in PubMed/MEDLINE, Scopus, and Cochrane Library databases was performed in accordance with the Pr...
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| Veröffentlicht in: | Journal of photochemistry and photobiology. B, Biology Biology, 2017-04, Vol.169, p.83-89 |
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| creator | Santinoni, Carolina dos Santos Oliveira, Hiskell Francine Fernandes Batista, Victor Eduardo de Souza Lemos, Cleidiel Aparecido Araujo Verri, Fellippo Ramos |
| description | This systematic review evaluates the effectiveness of low-level laser therapy (LLLT) to enhance maxillofacial area bone repair.
A comprehensive search of studies published up to February 2017 and listed in PubMed/MEDLINE, Scopus, and Cochrane Library databases was performed in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement.
The 15 selected studies evaluated a total of 374 patients (mean age, 28.5years) who were treated with LLLT. Gallium-arsenide (GaAs) and gallium aluminium arsenide (GaAlAs) were the most commonly used devices, and LLLT parameters varied greatly. Wavelengths varied from 500 to 1000nm. Tooth extraction, distraction osteogenesis, maxillary expansion, periodontal defects, orthodontic movement and maxillary cystic defects were evaluated. From the 15 selected studies, six evaluated bone repair (primary outcomes). Of these, four studies showed improvement in bone formation after using LLLT, two demonstrated improved results for only one follow up period, and one showed no additional benefits. The other 9 studies evaluated secondary parameters related to healing (secondary outcomes) in the maxillofacial area after applying LLLT, including anti-inflammatory, analgesic, and healing accelerator effects, and quality of life related to oral health. There were no adverse or negative effects of LLLT reported.
Within the limitation of this review, a possible improvement in bone density can be found when LLLT is applied postoperatively in maxillofacial bony defects. LLLT also seems to promote anti-inflammatory and analgesic effects and accelerate healing, as well as enhance quality of life related to oral health. However, LLLT use protocols need to be standardized before more specific conclusions can be drawn about this subject.
•A systematic review on the clinical effect of LLLT on bone repair was performed.•Fifteen randomized clinical trials were selected for the analysis.•Six studies evaluated bone formation with LLLT. Of these, five showed improvement.•Other nine studies evaluated other benefits related to healing.•There were no adverse or negative effects of LLLT reported. |
| doi_str_mv | 10.1016/j.jphotobiol.2017.03.004 |
| format | Article |
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A comprehensive search of studies published up to February 2017 and listed in PubMed/MEDLINE, Scopus, and Cochrane Library databases was performed in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement.
The 15 selected studies evaluated a total of 374 patients (mean age, 28.5years) who were treated with LLLT. Gallium-arsenide (GaAs) and gallium aluminium arsenide (GaAlAs) were the most commonly used devices, and LLLT parameters varied greatly. Wavelengths varied from 500 to 1000nm. Tooth extraction, distraction osteogenesis, maxillary expansion, periodontal defects, orthodontic movement and maxillary cystic defects were evaluated. From the 15 selected studies, six evaluated bone repair (primary outcomes). Of these, four studies showed improvement in bone formation after using LLLT, two demonstrated improved results for only one follow up period, and one showed no additional benefits. The other 9 studies evaluated secondary parameters related to healing (secondary outcomes) in the maxillofacial area after applying LLLT, including anti-inflammatory, analgesic, and healing accelerator effects, and quality of life related to oral health. There were no adverse or negative effects of LLLT reported.
Within the limitation of this review, a possible improvement in bone density can be found when LLLT is applied postoperatively in maxillofacial bony defects. LLLT also seems to promote anti-inflammatory and analgesic effects and accelerate healing, as well as enhance quality of life related to oral health. However, LLLT use protocols need to be standardized before more specific conclusions can be drawn about this subject.
•A systematic review on the clinical effect of LLLT on bone repair was performed.•Fifteen randomized clinical trials were selected for the analysis.•Six studies evaluated bone formation with LLLT. Of these, five showed improvement.•Other nine studies evaluated other benefits related to healing.•There were no adverse or negative effects of LLLT reported.</description><identifier>ISSN: 1011-1344</identifier><identifier>ISSN: 1873-2682</identifier><identifier>EISSN: 1873-2682</identifier><identifier>DOI: 10.1016/j.jphotobiol.2017.03.004</identifier><identifier>PMID: 28292696</identifier><language>eng</language><publisher>Switzerland: Elsevier B.V</publisher><subject>Adult ; Aluminum gallium arsenides ; Analgesics ; Arsenides ; Biocompatibility ; Biomedical materials ; Bone ; Bone density ; Bone growth ; Bone healing ; Bone regeneration ; Defects ; Dentistry ; Distraction osteogenesis ; Gallium arsenide ; Healing ; Humans ; Inflammation ; Intermetallic compounds ; Lasers ; Light emitting diodes ; Low-level laser therapy ; Low-Level Light Therapy - methods ; Maxilla ; Maxillofacial ; Maxillofacial Abnormalities - pathology ; Maxillofacial Abnormalities - therapy ; Maxillofacial Injuries - pathology ; Maxillofacial Injuries - therapy ; Orthodontics ; Osteogenesis ; Periodontics ; Quality of life ; Repair ; Review ; Systematic review ; Teeth ; Therapy ; Tissue engineering ; Wavelengths ; Wound Healing</subject><ispartof>Journal of photochemistry and photobiology. B, Biology, 2017-04, Vol.169, p.83-89</ispartof><rights>2017 Elsevier B.V.</rights><rights>Copyright © 2017 Elsevier B.V. All rights reserved.</rights><rights>Copyright Elsevier BV Apr 2017</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c518t-4b084ab904995267b4d98505ef7ad73f93967746eaf5bb12e706355d085e78b53</citedby><cites>FETCH-LOGICAL-c518t-4b084ab904995267b4d98505ef7ad73f93967746eaf5bb12e706355d085e78b53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S101113441630793X$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27903,27904,65309</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28292696$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Santinoni, Carolina dos Santos</creatorcontrib><creatorcontrib>Oliveira, Hiskell Francine Fernandes</creatorcontrib><creatorcontrib>Batista, Victor Eduardo de Souza</creatorcontrib><creatorcontrib>Lemos, Cleidiel Aparecido Araujo</creatorcontrib><creatorcontrib>Verri, Fellippo Ramos</creatorcontrib><title>Influence of low-level laser therapy on the healing of human bone maxillofacial defects: A systematic review</title><title>Journal of photochemistry and photobiology. B, Biology</title><addtitle>J Photochem Photobiol B</addtitle><description>This systematic review evaluates the effectiveness of low-level laser therapy (LLLT) to enhance maxillofacial area bone repair.
A comprehensive search of studies published up to February 2017 and listed in PubMed/MEDLINE, Scopus, and Cochrane Library databases was performed in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement.
The 15 selected studies evaluated a total of 374 patients (mean age, 28.5years) who were treated with LLLT. Gallium-arsenide (GaAs) and gallium aluminium arsenide (GaAlAs) were the most commonly used devices, and LLLT parameters varied greatly. Wavelengths varied from 500 to 1000nm. Tooth extraction, distraction osteogenesis, maxillary expansion, periodontal defects, orthodontic movement and maxillary cystic defects were evaluated. From the 15 selected studies, six evaluated bone repair (primary outcomes). Of these, four studies showed improvement in bone formation after using LLLT, two demonstrated improved results for only one follow up period, and one showed no additional benefits. The other 9 studies evaluated secondary parameters related to healing (secondary outcomes) in the maxillofacial area after applying LLLT, including anti-inflammatory, analgesic, and healing accelerator effects, and quality of life related to oral health. There were no adverse or negative effects of LLLT reported.
Within the limitation of this review, a possible improvement in bone density can be found when LLLT is applied postoperatively in maxillofacial bony defects. LLLT also seems to promote anti-inflammatory and analgesic effects and accelerate healing, as well as enhance quality of life related to oral health. However, LLLT use protocols need to be standardized before more specific conclusions can be drawn about this subject.
•A systematic review on the clinical effect of LLLT on bone repair was performed.•Fifteen randomized clinical trials were selected for the analysis.•Six studies evaluated bone formation with LLLT. Of these, five showed improvement.•Other nine studies evaluated other benefits related to healing.•There were no adverse or negative effects of LLLT reported.</description><subject>Adult</subject><subject>Aluminum gallium arsenides</subject><subject>Analgesics</subject><subject>Arsenides</subject><subject>Biocompatibility</subject><subject>Biomedical materials</subject><subject>Bone</subject><subject>Bone density</subject><subject>Bone growth</subject><subject>Bone healing</subject><subject>Bone regeneration</subject><subject>Defects</subject><subject>Dentistry</subject><subject>Distraction osteogenesis</subject><subject>Gallium arsenide</subject><subject>Healing</subject><subject>Humans</subject><subject>Inflammation</subject><subject>Intermetallic compounds</subject><subject>Lasers</subject><subject>Light emitting diodes</subject><subject>Low-level laser therapy</subject><subject>Low-Level Light Therapy - methods</subject><subject>Maxilla</subject><subject>Maxillofacial</subject><subject>Maxillofacial Abnormalities - pathology</subject><subject>Maxillofacial Abnormalities - therapy</subject><subject>Maxillofacial Injuries - pathology</subject><subject>Maxillofacial Injuries - therapy</subject><subject>Orthodontics</subject><subject>Osteogenesis</subject><subject>Periodontics</subject><subject>Quality of life</subject><subject>Repair</subject><subject>Review</subject><subject>Systematic review</subject><subject>Teeth</subject><subject>Therapy</subject><subject>Tissue engineering</subject><subject>Wavelengths</subject><subject>Wound Healing</subject><issn>1011-1344</issn><issn>1873-2682</issn><issn>1873-2682</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkc1u1TAQRi0EoqXlFZAlNmwS7Dj-CbtSFahUqRu6tuxkzHXkxBc7aXvfvo5uAYlNZ-NZnJmxvoMQpqSmhIrPYz3ud3GJ1sdQN4TKmrCakPYVOqVKsqoRqnldekJpRVnbnqB3OY-kFBfyLTppVNM1ohOnKFzPLqww94CjwyE-VAHuIeBgMiS87CCZ_QHHeWvxDkzw86-N3K2TmbGNM-DJPPoQojO9NwEP4KBf8hd8gfMhLzCZxfc4wb2Hh3P0xpmQ4f3ze4buvl39vPxR3dx-v768uKl6TtVStZao1tiOtF3HGyFtO3SKEw5OmkEy17FOSNkKMI5bSxuQRDDOB6I4SGU5O0Ofjnv3Kf5eIS968rmHEMwMcc26ZCQVp5LTgn78Dx3jmubyO007JjjliqtCqSPVp5hzAqf3yU8mHTQlejOiR_3PiN6MaMJ0MVJGPzwfWO0Ew9_BPwoK8PUIQEmkpJR07v0mZPCpJKmH6F--8gTz4aGT</recordid><startdate>201704</startdate><enddate>201704</enddate><creator>Santinoni, Carolina dos Santos</creator><creator>Oliveira, Hiskell Francine Fernandes</creator><creator>Batista, Victor Eduardo de Souza</creator><creator>Lemos, Cleidiel Aparecido Araujo</creator><creator>Verri, Fellippo Ramos</creator><general>Elsevier B.V</general><general>Elsevier BV</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7TK</scope><scope>7U7</scope><scope>C1K</scope><scope>7X8</scope></search><sort><creationdate>201704</creationdate><title>Influence of low-level laser therapy on the healing of human bone maxillofacial defects: A systematic review</title><author>Santinoni, Carolina dos Santos ; 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B, Biology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Santinoni, Carolina dos Santos</au><au>Oliveira, Hiskell Francine Fernandes</au><au>Batista, Victor Eduardo de Souza</au><au>Lemos, Cleidiel Aparecido Araujo</au><au>Verri, Fellippo Ramos</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Influence of low-level laser therapy on the healing of human bone maxillofacial defects: A systematic review</atitle><jtitle>Journal of photochemistry and photobiology. B, Biology</jtitle><addtitle>J Photochem Photobiol B</addtitle><date>2017-04</date><risdate>2017</risdate><volume>169</volume><spage>83</spage><epage>89</epage><pages>83-89</pages><issn>1011-1344</issn><issn>1873-2682</issn><eissn>1873-2682</eissn><abstract>This systematic review evaluates the effectiveness of low-level laser therapy (LLLT) to enhance maxillofacial area bone repair.
A comprehensive search of studies published up to February 2017 and listed in PubMed/MEDLINE, Scopus, and Cochrane Library databases was performed in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) statement.
The 15 selected studies evaluated a total of 374 patients (mean age, 28.5years) who were treated with LLLT. Gallium-arsenide (GaAs) and gallium aluminium arsenide (GaAlAs) were the most commonly used devices, and LLLT parameters varied greatly. Wavelengths varied from 500 to 1000nm. Tooth extraction, distraction osteogenesis, maxillary expansion, periodontal defects, orthodontic movement and maxillary cystic defects were evaluated. From the 15 selected studies, six evaluated bone repair (primary outcomes). Of these, four studies showed improvement in bone formation after using LLLT, two demonstrated improved results for only one follow up period, and one showed no additional benefits. The other 9 studies evaluated secondary parameters related to healing (secondary outcomes) in the maxillofacial area after applying LLLT, including anti-inflammatory, analgesic, and healing accelerator effects, and quality of life related to oral health. There were no adverse or negative effects of LLLT reported.
Within the limitation of this review, a possible improvement in bone density can be found when LLLT is applied postoperatively in maxillofacial bony defects. LLLT also seems to promote anti-inflammatory and analgesic effects and accelerate healing, as well as enhance quality of life related to oral health. However, LLLT use protocols need to be standardized before more specific conclusions can be drawn about this subject.
•A systematic review on the clinical effect of LLLT on bone repair was performed.•Fifteen randomized clinical trials were selected for the analysis.•Six studies evaluated bone formation with LLLT. Of these, five showed improvement.•Other nine studies evaluated other benefits related to healing.•There were no adverse or negative effects of LLLT reported.</abstract><cop>Switzerland</cop><pub>Elsevier B.V</pub><pmid>28292696</pmid><doi>10.1016/j.jphotobiol.2017.03.004</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Adult Aluminum gallium arsenides Analgesics Arsenides Biocompatibility Biomedical materials Bone Bone density Bone growth Bone healing Bone regeneration Defects Dentistry Distraction osteogenesis Gallium arsenide Healing Humans Inflammation Intermetallic compounds Lasers Light emitting diodes Low-level laser therapy Low-Level Light Therapy - methods Maxilla Maxillofacial Maxillofacial Abnormalities - pathology Maxillofacial Abnormalities - therapy Maxillofacial Injuries - pathology Maxillofacial Injuries - therapy Orthodontics Osteogenesis Periodontics Quality of life Repair Review Systematic review Teeth Therapy Tissue engineering Wavelengths Wound Healing |
| title | Influence of low-level laser therapy on the healing of human bone maxillofacial defects: A systematic review |
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