Molecular mechanisms of neuroinflammation and injury during acute viral encephalitis
Abstract Viral infections in the central nervous system are a major cause of encephalitis. West Nile virus (WNV) and Herpes simplex virus (HSV) are the most common causes of viral encephalitis in the United States. We review the role of neuroinflammation in the pathogenesis of WNV and HSV infections...
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| Veröffentlicht in: | Journal of neuroimmunology 2017-07, Vol.308, p.102-111 |
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| container_title | Journal of neuroimmunology |
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| creator | Shives, Katherine D Tyler, Kenneth L Beckham, J. David |
| description | Abstract Viral infections in the central nervous system are a major cause of encephalitis. West Nile virus (WNV) and Herpes simplex virus (HSV) are the most common causes of viral encephalitis in the United States. We review the role of neuroinflammation in the pathogenesis of WNV and HSV infections in the central nervous system (CNS). We discuss the role of the innate and cell-mediated immune responses in peripheral control of viral infection, viral invasion of the CNS, and in inflammatory-mediated neuronal injury. By understanding the role of specific inflammatory responses to viral infections in the CNS, targeted therapeutic approaches can be developed to maximize control of acute viral infection while minimizing neuronal injury in the CNS. |
| doi_str_mv | 10.1016/j.jneuroim.2017.03.006 |
| format | Article |
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| ispartof | Journal of neuroimmunology, 2017-07, Vol.308, p.102-111 |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete |
| subjects | Allergy and Immunology Animals Central Nervous System - immunology Central Nervous System - pathology Central Nervous System - virology Encephalitis Encephalitis, Viral - complications Encephalitis, Viral - immunology Encephalitis, Viral - pathology Herpes simplex virus Humans Innate immunity Neurology Simplexvirus - pathogenicity West Nile virus West Nile virus - pathogenicity |
| title | Molecular mechanisms of neuroinflammation and injury during acute viral encephalitis |
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