Geodesic distance on a Grassmannian for monitoring the progression of Alzheimer's disease

We propose a geodesic distance on a Grassmannian manifold that can be used to quantify the shape progression patterns of the bilateral hippocampi, amygdalas, and lateral ventricles in healthy control (HC), mild cognitive impairment (MCI), and Alzheimer's disease (AD). Longitudinal magnetic reso...

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Veröffentlicht in:	NeuroImage (Orlando, Fla.) Fla.), 2017-02, Vol.146, p.1016-1024
Hauptverfasser:	Gui, Liangyan, Tang, Xiaoying, Moura, José M.F.
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Aged, 80 and over Alzheimer Disease - diagnostic imaging Alzheimer Disease - pathology Alzheimer's disease Amygdala Amygdala - diagnostic imaging Amygdala - pathology Behavior rating scales Brain - diagnostic imaging Brain - pathology Brain Mapping - methods Cognitive ability Cognitive Dysfunction - diagnostic imaging Cognitive Dysfunction - pathology Disease Progression Euclidean space Female Geodesic distance Grassmannian Hippocampus Hippocampus - diagnostic imaging Hippocampus - pathology Humans Lateral Ventricles - diagnostic imaging Lateral Ventricles - pathology Linear Models Magnetic Resonance Imaging Male Mathematical models Middle Aged Neurodegenerative diseases Neuropathology NMR Nuclear magnetic resonance Shape Ventricle (lateral) Volumetric analysis
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