Guided introduction after negative double-blind placebo-controlled peanut challenges in children

A diagnostic double-blind placebo-controlled food challenge (DBPCFC) is the gold standard to confirm or exclude a peanut allergy.1 After a negative food challenge, parents and children report less fear of an allergic reaction and better quality of life.2 Moreover, a negative food challenge usually results in the introduction of peanut at home and when successful no restrictions when eating out or buying and cooking food related to peanut. Aversion was also a common problem despite the offering of alternative products with hidden peanut.\n05 0.10 0.10 M - - - Yes Yes 0 - Yes No Aversion No 69 0.07 0.10 0.10 0.01 Changed stool >2 h - Changed stool >2 h No Yes 2 - No Yes Not convinced about challenge outcome No 75 0.51 0.10 4.19 52.00 - - - No No - - Yes Yes Aversion, fear No 85 0.44 0.23 0.10 0.05 - OAS OAS Yes No - OAS Yes Yes Symptoms Yes 88 0.02 0.10 0.10 M - - - No No - OAS Yes Yes Symptoms No 91 0.37 0.10 0.10 M - ABP - No No - - No Yes Aversion, fear No 99 2.12 0.94 0.10 0.03 - OAS OAS Yes Yes 1 - No Yes Frequency No 100 5.50 4.80 18.50 101.00 - ABP, OAS OAS Yes No - OAS No Yes Symptoms Yes (b) Introduction success (n = 23) 6 0.49 0.10 2.05 27.40 Redness Yes Yes 2 Yes No - No 12 0.11 0.10 0.10 M ABP Yes Yes 2 Yes No - No 16 0.08 0.10 0.10 0.09 Yes Yes 2 Yes No - No 18 17.80 0.39 0.31 33.40 Yes Yes 2 Yes Yes - No 24 0.94 0.10 0.10 0.03 Yes Yes 12 Yes No - No 25 0.06 0.10 0.10 0.16 ABP Yes Yes 12 Yes Yes - No 29 10.60 0.29 100.00 100.00 OAS OAS, cough Yes Yes 2 Yes Yes - No 31 0.34 0.10 11.07 19.60 Yes Yes 4 Yes Yes - No 41 1.02 0.80 0.10 0.34 Vomiting (aversion) Yes Yes 2 Wheeze and cough due to coinfection Yes Yes - No 48 7.30 0.61 0.62 100.00 Incomplete ingestion Yes Yes 4 Yes No - No 49 0.72 0.81 0.77 M ABP ABP ABP Yes Yes 4 ABP, nausea, redness once only Yes No - No 51 1.74 0.10 24.55 101.00 Yes Yes 6 Yes Yes - No 57 0.59 0.10 0.10 0.79 Vomiting >2 h Yes Yes 6 Yes Yes - No 58 1.39 0.10 4.18 27.40 OAS, feeling dyspnoe Yes Yes 6 OAS once only Yes Yes - No 63 0.43 0.41 4.03 15.70 Yes Yes 20 Yes No - No 81 1.72 0.10 0.10 3.34 Changed stool >2 h Yes Yes 2 Yes No - No 82 1.57 0.10 1.52 4.10 Yes Yes 30 Yes No - No 83 1.64 0.56 8.88 20.40 Yes Yes 3 Perioral eczema Yes Yes - No 84 2.73 0.10 16.50 M Swollen eye ABP Yes Yes 21 Yes Yes - No 86 0.05 0.10 0.10 4.10 Redness Yes Yes 30 Yes Yes - No 90 0.03 0.10 .10 M ABP Yes Yes 5 ABP Yes No - No 92 0.08 0.10 0.10 0.02 Yes Yes M Yes M - No 101 1.55 0.02 3.39 31.30 Yes Yes 8 Yes No - No Table II Children with (a) in