Relative validation of 24-h urinary hippuric acid excretion as a biomarker for dietary flavonoid intake from fruit and vegetables in healthy adolescents
Purpose A biomarker for dietary flavonoid intake from fruit and vegetables (FlavFV) is needed to elucidate the relevance of flavonoids from these sources for the prevention of chronic diseases. Urinary hippuric acid (HA)—a major metabolite of flavonoids—is promising in this respect as it was shown t...
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| Veröffentlicht in: | European journal of nutrition 2017-03, Vol.56 (2), p.757-766 |
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| creator | Penczynski, Katharina J. Krupp, Danika Bring, Anna Bolzenius, Katja Remer, Thomas Buyken, Anette E. |
| description | Purpose
A biomarker for dietary flavonoid intake from fruit and vegetables (FlavFV) is needed to elucidate the relevance of flavonoids from these sources for the prevention of chronic diseases. Urinary hippuric acid (HA)—a major metabolite of flavonoids—is promising in this respect as it was shown to satisfyingly indicate fruit and vegetable consumption in different age groups. Therefore, we validated urinary HA as a biomarker for intake of FlavFV.
Methods
Analyses included data from 287 healthy adolescents of the DONALD Study (aged 9–16 years) for whom a minimum of two pairs of HA measurements from 24-h urine samples (test method) and FlavFV intake estimated from 3-day weighed dietary records (reference method) existed. Agreement between both methods was assessed by Spearman correlation and cross-classification analyses. Possible confounders of the association were identified by linear regression models. Analyses were performed using a split-sample approach allowing for consecutive exploration (
n
= 192) and confirmation (
n
= 95) of results.
Results
Agreement between urinary HA excretion and FlavFV intake was moderate according to correlation analysis in the exploratory sample (
r
unadjusted
= 0.47,
P
|
| doi_str_mv | 10.1007/s00394-015-1121-9 |
| format | Article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1877844295</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1877844295</sourcerecordid><originalsourceid>FETCH-LOGICAL-c405t-4fa99889c767040fea5e511d4da2f76b1447954787cbcd71ea29b9b98d3e906d3</originalsourceid><addsrcrecordid>eNqNkd9qFDEUxgdRbG19AG8k4I03Y5OZ_JlcStEqFIRir8OZ5Ew37exkTWaW7pv4uJ7t1iKCIIHkkPy-L8n5quqN4B8E5-ascN5aWXOhaiEaUdtn1bGQra51I9Tzp5qbo-pVKbec86bV4mV11GitOqPVcfXzCkeY4xbZFsYYqEwTSwNrZL1iS44T5B1bxc2Gas_Ax8Dw3md84KAwYH1Ma8h3mNmQMgsR571kGGGbpkR4nGa4QzbktKZpiTODKbAt3hDYj1gIYCuEcV7tGIREOx6nuZxWLwYYC75-XE-q68-fvp9_qS-_XXw9_3hZe8nVXMsBrO066402XPIBQaESIsgAzWB0L6Q0VknTGd_7YARCY3saXWjRch3ak-r9wXeT048Fy-zWkV4wjjBhWooTnTGdlI1V_4FSX6WysiP03V_obVryRB_ZG1IIshWaKHGgfE6lZBzcJkdq5s4J7vYJu0PCjhJ2-4SdJc3bR-elX2N4UvyOlIDmABQ6mm4w_3H1P11_AfDBsjU</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1873614316</pqid></control><display><type>article</type><title>Relative validation of 24-h urinary hippuric acid excretion as a biomarker for dietary flavonoid intake from fruit and vegetables in healthy adolescents</title><source>MEDLINE</source><source>SpringerNature Journals</source><creator>Penczynski, Katharina J. ; Krupp, Danika ; Bring, Anna ; Bolzenius, Katja ; Remer, Thomas ; Buyken, Anette E.</creator><creatorcontrib>Penczynski, Katharina J. ; Krupp, Danika ; Bring, Anna ; Bolzenius, Katja ; Remer, Thomas ; Buyken, Anette E.</creatorcontrib><description>Purpose
A biomarker for dietary flavonoid intake from fruit and vegetables (FlavFV) is needed to elucidate the relevance of flavonoids from these sources for the prevention of chronic diseases. Urinary hippuric acid (HA)—a major metabolite of flavonoids—is promising in this respect as it was shown to satisfyingly indicate fruit and vegetable consumption in different age groups. Therefore, we validated urinary HA as a biomarker for intake of FlavFV.
Methods
Analyses included data from 287 healthy adolescents of the DONALD Study (aged 9–16 years) for whom a minimum of two pairs of HA measurements from 24-h urine samples (test method) and FlavFV intake estimated from 3-day weighed dietary records (reference method) existed. Agreement between both methods was assessed by Spearman correlation and cross-classification analyses. Possible confounders of the association were identified by linear regression models. Analyses were performed using a split-sample approach allowing for consecutive exploration (
n
= 192) and confirmation (
n
= 95) of results.
Results
Agreement between urinary HA excretion and FlavFV intake was moderate according to correlation analysis in the exploratory sample (
r
unadjusted
= 0.47,
P
< 0.0001). Yet, 79 % of the subjects were classified into same/adjacent quartiles, and only 5 % were misclassified into opposite quartiles. These findings were corroborated by analyses in the confirmatory sample (
r
unadjusted
= 0.64; 88 % in same/adjacent vs. 4 % in opposite quartiles). Body surface area (BSA) was the only relevant covariate in the exploratory sample, and its adjustment improved cross-classification estimates in both subsamples.
Conclusions
BSA-adjusted 24-h urinary HA excretion represents a suitable biomarker of habitual FlavFV intake in healthy adolescents.</description><identifier>ISSN: 1436-6207</identifier><identifier>EISSN: 1436-6215</identifier><identifier>DOI: 10.1007/s00394-015-1121-9</identifier><identifier>PMID: 26658765</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Adolescent ; Adolescent Nutritional Physiological Phenomena - ethnology ; Biomarkers - urine ; Body Surface Area ; Chemistry ; Chemistry and Materials Science ; Child ; Child Nutritional Physiological Phenomena - ethnology ; Cohort Studies ; Diet Records ; Female ; Flavonoids - administration & dosage ; Fruit - chemistry ; Germany ; Healthy Diet - ethnology ; Hippurates - urine ; Humans ; Longitudinal Studies ; Male ; Nutrition ; Nutrition Assessment ; Original Contribution ; Patient Compliance - ethnology ; Regression Analysis ; Renal Elimination ; Vegetables - chemistry</subject><ispartof>European journal of nutrition, 2017-03, Vol.56 (2), p.757-766</ispartof><rights>Springer-Verlag Berlin Heidelberg 2015</rights><rights>European Journal of Nutrition is a copyright of Springer, 2017.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c405t-4fa99889c767040fea5e511d4da2f76b1447954787cbcd71ea29b9b98d3e906d3</citedby><cites>FETCH-LOGICAL-c405t-4fa99889c767040fea5e511d4da2f76b1447954787cbcd71ea29b9b98d3e906d3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00394-015-1121-9$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00394-015-1121-9$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26658765$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Penczynski, Katharina J.</creatorcontrib><creatorcontrib>Krupp, Danika</creatorcontrib><creatorcontrib>Bring, Anna</creatorcontrib><creatorcontrib>Bolzenius, Katja</creatorcontrib><creatorcontrib>Remer, Thomas</creatorcontrib><creatorcontrib>Buyken, Anette E.</creatorcontrib><title>Relative validation of 24-h urinary hippuric acid excretion as a biomarker for dietary flavonoid intake from fruit and vegetables in healthy adolescents</title><title>European journal of nutrition</title><addtitle>Eur J Nutr</addtitle><addtitle>Eur J Nutr</addtitle><description>Purpose
A biomarker for dietary flavonoid intake from fruit and vegetables (FlavFV) is needed to elucidate the relevance of flavonoids from these sources for the prevention of chronic diseases. Urinary hippuric acid (HA)—a major metabolite of flavonoids—is promising in this respect as it was shown to satisfyingly indicate fruit and vegetable consumption in different age groups. Therefore, we validated urinary HA as a biomarker for intake of FlavFV.
Methods
Analyses included data from 287 healthy adolescents of the DONALD Study (aged 9–16 years) for whom a minimum of two pairs of HA measurements from 24-h urine samples (test method) and FlavFV intake estimated from 3-day weighed dietary records (reference method) existed. Agreement between both methods was assessed by Spearman correlation and cross-classification analyses. Possible confounders of the association were identified by linear regression models. Analyses were performed using a split-sample approach allowing for consecutive exploration (
n
= 192) and confirmation (
n
= 95) of results.
Results
Agreement between urinary HA excretion and FlavFV intake was moderate according to correlation analysis in the exploratory sample (
r
unadjusted
= 0.47,
P
< 0.0001). Yet, 79 % of the subjects were classified into same/adjacent quartiles, and only 5 % were misclassified into opposite quartiles. These findings were corroborated by analyses in the confirmatory sample (
r
unadjusted
= 0.64; 88 % in same/adjacent vs. 4 % in opposite quartiles). Body surface area (BSA) was the only relevant covariate in the exploratory sample, and its adjustment improved cross-classification estimates in both subsamples.
Conclusions
BSA-adjusted 24-h urinary HA excretion represents a suitable biomarker of habitual FlavFV intake in healthy adolescents.</description><subject>Adolescent</subject><subject>Adolescent Nutritional Physiological Phenomena - ethnology</subject><subject>Biomarkers - urine</subject><subject>Body Surface Area</subject><subject>Chemistry</subject><subject>Chemistry and Materials Science</subject><subject>Child</subject><subject>Child Nutritional Physiological Phenomena - ethnology</subject><subject>Cohort Studies</subject><subject>Diet Records</subject><subject>Female</subject><subject>Flavonoids - administration & dosage</subject><subject>Fruit - chemistry</subject><subject>Germany</subject><subject>Healthy Diet - ethnology</subject><subject>Hippurates - urine</subject><subject>Humans</subject><subject>Longitudinal Studies</subject><subject>Male</subject><subject>Nutrition</subject><subject>Nutrition Assessment</subject><subject>Original Contribution</subject><subject>Patient Compliance - ethnology</subject><subject>Regression Analysis</subject><subject>Renal Elimination</subject><subject>Vegetables - chemistry</subject><issn>1436-6207</issn><issn>1436-6215</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><recordid>eNqNkd9qFDEUxgdRbG19AG8k4I03Y5OZ_JlcStEqFIRir8OZ5Ew37exkTWaW7pv4uJ7t1iKCIIHkkPy-L8n5quqN4B8E5-ascN5aWXOhaiEaUdtn1bGQra51I9Tzp5qbo-pVKbec86bV4mV11GitOqPVcfXzCkeY4xbZFsYYqEwTSwNrZL1iS44T5B1bxc2Gas_Ax8Dw3md84KAwYH1Ma8h3mNmQMgsR571kGGGbpkR4nGa4QzbktKZpiTODKbAt3hDYj1gIYCuEcV7tGIREOx6nuZxWLwYYC75-XE-q68-fvp9_qS-_XXw9_3hZe8nVXMsBrO066402XPIBQaESIsgAzWB0L6Q0VknTGd_7YARCY3saXWjRch3ak-r9wXeT048Fy-zWkV4wjjBhWooTnTGdlI1V_4FSX6WysiP03V_obVryRB_ZG1IIshWaKHGgfE6lZBzcJkdq5s4J7vYJu0PCjhJ2-4SdJc3bR-elX2N4UvyOlIDmABQ6mm4w_3H1P11_AfDBsjU</recordid><startdate>20170301</startdate><enddate>20170301</enddate><creator>Penczynski, Katharina J.</creator><creator>Krupp, Danika</creator><creator>Bring, Anna</creator><creator>Bolzenius, Katja</creator><creator>Remer, Thomas</creator><creator>Buyken, Anette E.</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7RQ</scope><scope>7RV</scope><scope>7TS</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9-</scope><scope>K9.</scope><scope>KB0</scope><scope>M0R</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope></search><sort><creationdate>20170301</creationdate><title>Relative validation of 24-h urinary hippuric acid excretion as a biomarker for dietary flavonoid intake from fruit and vegetables in healthy adolescents</title><author>Penczynski, Katharina J. ; Krupp, Danika ; Bring, Anna ; Bolzenius, Katja ; Remer, Thomas ; Buyken, Anette E.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c405t-4fa99889c767040fea5e511d4da2f76b1447954787cbcd71ea29b9b98d3e906d3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Adolescent</topic><topic>Adolescent Nutritional Physiological Phenomena - ethnology</topic><topic>Biomarkers - urine</topic><topic>Body Surface Area</topic><topic>Chemistry</topic><topic>Chemistry and Materials Science</topic><topic>Child</topic><topic>Child Nutritional Physiological Phenomena - ethnology</topic><topic>Cohort Studies</topic><topic>Diet Records</topic><topic>Female</topic><topic>Flavonoids - administration & dosage</topic><topic>Fruit - chemistry</topic><topic>Germany</topic><topic>Healthy Diet - ethnology</topic><topic>Hippurates - urine</topic><topic>Humans</topic><topic>Longitudinal Studies</topic><topic>Male</topic><topic>Nutrition</topic><topic>Nutrition Assessment</topic><topic>Original Contribution</topic><topic>Patient Compliance - ethnology</topic><topic>Regression Analysis</topic><topic>Renal Elimination</topic><topic>Vegetables - chemistry</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Penczynski, Katharina J.</creatorcontrib><creatorcontrib>Krupp, Danika</creatorcontrib><creatorcontrib>Bring, Anna</creatorcontrib><creatorcontrib>Bolzenius, Katja</creatorcontrib><creatorcontrib>Remer, Thomas</creatorcontrib><creatorcontrib>Buyken, Anette E.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>Career & Technical Education Database</collection><collection>Nursing & Allied Health Database</collection><collection>Physical Education Index</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>Consumer Health Database (Alumni Edition)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>Consumer Health Database</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Nursing & Allied Health Premium</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><jtitle>European journal of nutrition</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Penczynski, Katharina J.</au><au>Krupp, Danika</au><au>Bring, Anna</au><au>Bolzenius, Katja</au><au>Remer, Thomas</au><au>Buyken, Anette E.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Relative validation of 24-h urinary hippuric acid excretion as a biomarker for dietary flavonoid intake from fruit and vegetables in healthy adolescents</atitle><jtitle>European journal of nutrition</jtitle><stitle>Eur J Nutr</stitle><addtitle>Eur J Nutr</addtitle><date>2017-03-01</date><risdate>2017</risdate><volume>56</volume><issue>2</issue><spage>757</spage><epage>766</epage><pages>757-766</pages><issn>1436-6207</issn><eissn>1436-6215</eissn><abstract>Purpose
A biomarker for dietary flavonoid intake from fruit and vegetables (FlavFV) is needed to elucidate the relevance of flavonoids from these sources for the prevention of chronic diseases. Urinary hippuric acid (HA)—a major metabolite of flavonoids—is promising in this respect as it was shown to satisfyingly indicate fruit and vegetable consumption in different age groups. Therefore, we validated urinary HA as a biomarker for intake of FlavFV.
Methods
Analyses included data from 287 healthy adolescents of the DONALD Study (aged 9–16 years) for whom a minimum of two pairs of HA measurements from 24-h urine samples (test method) and FlavFV intake estimated from 3-day weighed dietary records (reference method) existed. Agreement between both methods was assessed by Spearman correlation and cross-classification analyses. Possible confounders of the association were identified by linear regression models. Analyses were performed using a split-sample approach allowing for consecutive exploration (
n
= 192) and confirmation (
n
= 95) of results.
Results
Agreement between urinary HA excretion and FlavFV intake was moderate according to correlation analysis in the exploratory sample (
r
unadjusted
= 0.47,
P
< 0.0001). Yet, 79 % of the subjects were classified into same/adjacent quartiles, and only 5 % were misclassified into opposite quartiles. These findings were corroborated by analyses in the confirmatory sample (
r
unadjusted
= 0.64; 88 % in same/adjacent vs. 4 % in opposite quartiles). Body surface area (BSA) was the only relevant covariate in the exploratory sample, and its adjustment improved cross-classification estimates in both subsamples.
Conclusions
BSA-adjusted 24-h urinary HA excretion represents a suitable biomarker of habitual FlavFV intake in healthy adolescents.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>26658765</pmid><doi>10.1007/s00394-015-1121-9</doi><tpages>10</tpages></addata></record> |
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| identifier | ISSN: 1436-6207 |
| ispartof | European journal of nutrition, 2017-03, Vol.56 (2), p.757-766 |
| issn | 1436-6207 1436-6215 |
| language | eng |
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| source | MEDLINE; SpringerNature Journals |
| subjects | Adolescent Adolescent Nutritional Physiological Phenomena - ethnology Biomarkers - urine Body Surface Area Chemistry Chemistry and Materials Science Child Child Nutritional Physiological Phenomena - ethnology Cohort Studies Diet Records Female Flavonoids - administration & dosage Fruit - chemistry Germany Healthy Diet - ethnology Hippurates - urine Humans Longitudinal Studies Male Nutrition Nutrition Assessment Original Contribution Patient Compliance - ethnology Regression Analysis Renal Elimination Vegetables - chemistry |
| title | Relative validation of 24-h urinary hippuric acid excretion as a biomarker for dietary flavonoid intake from fruit and vegetables in healthy adolescents |
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