Frontline Science: ATF3 is responsible for the inhibition of TNF‐α release and the impaired migration of acute ethanol‐exposed monocytes and macrophages

Acute ethanol exposure decreases the production of LPS‐induced TNF‐α, and the migration of monocytes and macrophages via ATF3. Binge drinking represses host innate immunity and leads to a high risk of infection. Acute EtOH‐pretreated macrophages exhibit a decreased production of proinflammatory medi...

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Veröffentlicht in:	Journal of leukocyte biology 2017-03, Vol.101 (3), p.633-642
Hauptverfasser:	Hu, Chaojie, Meng, Xiaoming, Huang, Cheng, Shen, Chenlin, Li, Jun
Format:	Artikel
Sprache:	eng
Schlagworte:	Activating transcription factor 3 Activating Transcription Factor 3 - metabolism Animals Binge drinking Binge Drinking - metabolism Binge Drinking - pathology Cell Movement - drug effects Drinking behavior Ethanol Ethanol - toxicity Exposure HDAC1 Health risks Histone Deacetylase 1 - metabolism Immunity Inflammation Inhibition Innate immunity Leukocyte migration Lipopolysaccharides Lipopolysaccharides - pharmacology Macrophages Macrophages - drug effects Macrophages - metabolism Macrophages - pathology Male Mice Mice, Inbred C57BL Models, Biological Monocytes Monocytes - drug effects Monocytes - metabolism Monocytes - pathology Protein Binding - drug effects RAW 264.7 Cells Rodents TLR4 protein TLR4 tolerance Toll-Like Receptor 4 - metabolism Toll-like receptors Transcription Transcription, Genetic - drug effects Tumor Necrosis Factor-alpha - biosynthesis Tumor Necrosis Factor-alpha - genetics Tumor Necrosis Factor-alpha - secretion Tumor necrosis factor-α
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