Administration of Huperzia quadrifariata Extract, a Cholinesterase Inhibitory Alkaloid Mixture, has Neuroprotective Effects in a Rat Model of Cerebral Hypoxia–Ischemia

Neonatal hypoxia–ischemia (HI) is an etiologic component of several neurologic pathologies associated to cognitive impairment. The mechanisms involved in HI-induced tissue damage start immediately after HI and extend for days. Acetylcholine is an important neurotransmitter in the central nervous sys...

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Veröffentlicht in:	Neurochemical research 2017-02, Vol.42 (2), p.552-562
Hauptverfasser:	Odorcyk, F. K., Sanches, E. F., Nicola, F. C., Moraes, J., Pettenuzzo, L. F., Kolling, J., Siebert, C., Longoni, A., Konrath, E. L., Wyse, A., Netto, C. A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Alkaloids - isolation & purification Alkaloids - pharmacology Alkaloids - therapeutic use Animals Animals, Newborn Biochemistry Biomedical and Life Sciences Biomedicine Cell Biology Cholinesterase Inhibitors - isolation & purification Cholinesterase Inhibitors - pharmacology Cholinesterase Inhibitors - therapeutic use Disease Models, Animal Female Huperzia Hypoxia-Ischemia, Brain - enzymology Hypoxia-Ischemia, Brain - prevention & control Male Maze Learning - drug effects Maze Learning - physiology Neurochemistry Neurology Neuroprotective Agents - isolation & purification Neuroprotective Agents - pharmacology Neuroprotective Agents - therapeutic use Neurosciences Original Paper Plant Components, Aerial Plant Extracts - isolation & purification Plant Extracts - pharmacology Plant Extracts - therapeutic use Rats Rats, Wistar Treatment Outcome
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