Changing pulsatility by delaying the rotational speed phasing of a rotary left ventricular assist device
Continuous-flow left ventricular assist devices (LVADs) have improved the prognosis of end-stage heart failure. However, continuous-flow LVADs diminish pulsatility, which possibly result in bleeding, aortic insufficiency, and other adverse effects. We previously developed a novel control system for...
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| Veröffentlicht in: | Journal of artificial organs 2017-03, Vol.20 (1), p.18-25 |
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| creator | Date, Kazuma Nishimura, Takashi Arakawa, Mamoru Takewa, Yoshiaki Kishimoto, Satoru Umeki, Akihide Ando, Masahiko Mizuno, Toshihide Tsukiya, Tomonori Ono, Minoru Tatsumi, Eisuke |
| description | Continuous-flow left ventricular assist devices (LVADs) have improved the prognosis of end-stage heart failure. However, continuous-flow LVADs diminish pulsatility, which possibly result in bleeding, aortic insufficiency, and other adverse effects. We previously developed a novel control system for a continuous-flow LVAD (EVAHEART
®
; Sun Medical), and demonstrated that we could create sufficient pulsatility by increasing its rotational speed (RS) in the systolic phase (Pulsatile Mode) in the normal heart model. Here, we aimed to evaluate differences between systolic assist with advanced and delayed loads by shifting the timing of increased RS. We implanted EVAHEART in six goats (55.3 ± 4.3 kg) with normal hearts. We reduced their heart rates to |
| doi_str_mv | 10.1007/s10047-016-0920-y |
| format | Article |
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®
; Sun Medical), and demonstrated that we could create sufficient pulsatility by increasing its rotational speed (RS) in the systolic phase (Pulsatile Mode) in the normal heart model. Here, we aimed to evaluate differences between systolic assist with advanced and delayed loads by shifting the timing of increased RS. We implanted EVAHEART in six goats (55.3 ± 4.3 kg) with normal hearts. We reduced their heart rates to <60 bpm using propranolol and controlled the heart rates at 80 and 120 bpm using ventricular pacing. We shifted the timing of increasing RS from −60 to +60 ms in the systolic phase. We found significant increases in all the following parameters when assessments of delayed timing (+60 ms) were compared with assessments of advanced timing (−60 ms): pulse pressure, mean d
P
/d
t
max of aortic pressure, and energy-equivalent pulse pressure. During continuous-flow LVAD support, pulsatility can be controlled using a rotary pump. In particular, pulsatility can be shifted by delaying increased RS.</description><identifier>ISSN: 1434-7229</identifier><identifier>EISSN: 1619-0904</identifier><identifier>DOI: 10.1007/s10047-016-0920-y</identifier><identifier>PMID: 27436097</identifier><language>eng</language><publisher>Tokyo: Springer Japan</publisher><subject>Animals ; Aortic Valve Insufficiency - etiology ; Biomedical Engineering and Bioengineering ; Blood Pressure ; Cardiac Surgery ; Goats ; Heart Failure - physiopathology ; Heart Failure - therapy ; Heart Rate - physiology ; Heart Ventricles - physiopathology ; Heart-Assist Devices - adverse effects ; Medicine ; Medicine & Public Health ; Nephrology ; Original Article ; Pulsatile Flow - physiology ; Systole</subject><ispartof>Journal of artificial organs, 2017-03, Vol.20 (1), p.18-25</ispartof><rights>The Japanese Society for Artificial Organs 2016</rights><rights>Journal of Artificial Organs is a copyright of Springer, 2017.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c495t-46d1605305712a03008dd0fc2bfeccbf6ce6a94aec6244af7ba6ba4a695d6db63</citedby><cites>FETCH-LOGICAL-c495t-46d1605305712a03008dd0fc2bfeccbf6ce6a94aec6244af7ba6ba4a695d6db63</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s10047-016-0920-y$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s10047-016-0920-y$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,780,784,27924,27925,41488,42557,51319</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27436097$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Date, Kazuma</creatorcontrib><creatorcontrib>Nishimura, Takashi</creatorcontrib><creatorcontrib>Arakawa, Mamoru</creatorcontrib><creatorcontrib>Takewa, Yoshiaki</creatorcontrib><creatorcontrib>Kishimoto, Satoru</creatorcontrib><creatorcontrib>Umeki, Akihide</creatorcontrib><creatorcontrib>Ando, Masahiko</creatorcontrib><creatorcontrib>Mizuno, Toshihide</creatorcontrib><creatorcontrib>Tsukiya, Tomonori</creatorcontrib><creatorcontrib>Ono, Minoru</creatorcontrib><creatorcontrib>Tatsumi, Eisuke</creatorcontrib><title>Changing pulsatility by delaying the rotational speed phasing of a rotary left ventricular assist device</title><title>Journal of artificial organs</title><addtitle>J Artif Organs</addtitle><addtitle>J Artif Organs</addtitle><description>Continuous-flow left ventricular assist devices (LVADs) have improved the prognosis of end-stage heart failure. However, continuous-flow LVADs diminish pulsatility, which possibly result in bleeding, aortic insufficiency, and other adverse effects. We previously developed a novel control system for a continuous-flow LVAD (EVAHEART
®
; Sun Medical), and demonstrated that we could create sufficient pulsatility by increasing its rotational speed (RS) in the systolic phase (Pulsatile Mode) in the normal heart model. Here, we aimed to evaluate differences between systolic assist with advanced and delayed loads by shifting the timing of increased RS. We implanted EVAHEART in six goats (55.3 ± 4.3 kg) with normal hearts. We reduced their heart rates to <60 bpm using propranolol and controlled the heart rates at 80 and 120 bpm using ventricular pacing. We shifted the timing of increasing RS from −60 to +60 ms in the systolic phase. We found significant increases in all the following parameters when assessments of delayed timing (+60 ms) were compared with assessments of advanced timing (−60 ms): pulse pressure, mean d
P
/d
t
max of aortic pressure, and energy-equivalent pulse pressure. During continuous-flow LVAD support, pulsatility can be controlled using a rotary pump. In particular, pulsatility can be shifted by delaying increased RS.</description><subject>Animals</subject><subject>Aortic Valve Insufficiency - etiology</subject><subject>Biomedical Engineering and Bioengineering</subject><subject>Blood Pressure</subject><subject>Cardiac Surgery</subject><subject>Goats</subject><subject>Heart Failure - physiopathology</subject><subject>Heart Failure - therapy</subject><subject>Heart Rate - physiology</subject><subject>Heart Ventricles - physiopathology</subject><subject>Heart-Assist Devices - adverse effects</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Nephrology</subject><subject>Original Article</subject><subject>Pulsatile Flow - physiology</subject><subject>Systole</subject><issn>1434-7229</issn><issn>1619-0904</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><recordid>eNqNkU-LFDEQxYMo7rr6AbxIwIuX1ko6nXSOMvgPFrzoOVSnq2d6yXS3SXqhv72ZmVVEELykknq_eoF6jL0U8FYAmHepnMpUIHQFVkK1PWLXQgtbXqAel7uqVWWktFfsWUp3AMI0Bp6yK2lUrcGaa3bYHXDaj9OeL2tImMcw5o13G-8p4Hbq5wPxOOcizRMGnhaini8HTCdxHjie1bjxQEPm9zTlOPo1YOSY0phycbofPT1nTwYMiV481Bv2_eOHb7vP1e3XT192728rr2yTK6V7oaGpoTFCItQAbd_D4GU3kPfdoD1ptArJa6kUDqZD3aFCbZte952ub9ibi-8S5x8rpeyOY_IUAk40r8mJ1phWCSnr_0ClNtLaM_r6L_RuXmPZx9mwlm2tW1socaF8nFOKNLgljseyGyfAnRJzl8RcScydEnNbmXn14Lx2R-p_T_yKqADyAqQiTXuKf3z9T9efc1Cikg</recordid><startdate>20170301</startdate><enddate>20170301</enddate><creator>Date, Kazuma</creator><creator>Nishimura, Takashi</creator><creator>Arakawa, Mamoru</creator><creator>Takewa, Yoshiaki</creator><creator>Kishimoto, Satoru</creator><creator>Umeki, Akihide</creator><creator>Ando, Masahiko</creator><creator>Mizuno, Toshihide</creator><creator>Tsukiya, Tomonori</creator><creator>Ono, Minoru</creator><creator>Tatsumi, Eisuke</creator><general>Springer Japan</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QO</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>ARAPS</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FR3</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>NAPCQ</scope><scope>P5Z</scope><scope>P62</scope><scope>P64</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope></search><sort><creationdate>20170301</creationdate><title>Changing pulsatility by delaying the rotational speed phasing of a rotary left ventricular assist device</title><author>Date, Kazuma ; Nishimura, Takashi ; Arakawa, Mamoru ; Takewa, Yoshiaki ; Kishimoto, Satoru ; Umeki, Akihide ; Ando, Masahiko ; Mizuno, Toshihide ; Tsukiya, Tomonori ; Ono, Minoru ; Tatsumi, Eisuke</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c495t-46d1605305712a03008dd0fc2bfeccbf6ce6a94aec6244af7ba6ba4a695d6db63</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Animals</topic><topic>Aortic Valve Insufficiency - etiology</topic><topic>Biomedical Engineering and Bioengineering</topic><topic>Blood Pressure</topic><topic>Cardiac Surgery</topic><topic>Goats</topic><topic>Heart Failure - physiopathology</topic><topic>Heart Failure - therapy</topic><topic>Heart Rate - physiology</topic><topic>Heart Ventricles - physiopathology</topic><topic>Heart-Assist Devices - adverse effects</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Nephrology</topic><topic>Original Article</topic><topic>Pulsatile Flow - physiology</topic><topic>Systole</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Date, Kazuma</creatorcontrib><creatorcontrib>Nishimura, Takashi</creatorcontrib><creatorcontrib>Arakawa, Mamoru</creatorcontrib><creatorcontrib>Takewa, Yoshiaki</creatorcontrib><creatorcontrib>Kishimoto, Satoru</creatorcontrib><creatorcontrib>Umeki, Akihide</creatorcontrib><creatorcontrib>Ando, Masahiko</creatorcontrib><creatorcontrib>Mizuno, Toshihide</creatorcontrib><creatorcontrib>Tsukiya, Tomonori</creatorcontrib><creatorcontrib>Ono, Minoru</creatorcontrib><creatorcontrib>Tatsumi, Eisuke</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Biotechnology Research Abstracts</collection><collection>Nursing & Allied Health Database</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>Advanced Technologies & Aerospace Collection</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Engineering Research Database</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Biological Science Database</collection><collection>Nursing & Allied Health Premium</collection><collection>Advanced Technologies & Aerospace Database</collection><collection>ProQuest Advanced Technologies & Aerospace Collection</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of artificial organs</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Date, Kazuma</au><au>Nishimura, Takashi</au><au>Arakawa, Mamoru</au><au>Takewa, Yoshiaki</au><au>Kishimoto, Satoru</au><au>Umeki, Akihide</au><au>Ando, Masahiko</au><au>Mizuno, Toshihide</au><au>Tsukiya, Tomonori</au><au>Ono, Minoru</au><au>Tatsumi, Eisuke</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Changing pulsatility by delaying the rotational speed phasing of a rotary left ventricular assist device</atitle><jtitle>Journal of artificial organs</jtitle><stitle>J Artif Organs</stitle><addtitle>J Artif Organs</addtitle><date>2017-03-01</date><risdate>2017</risdate><volume>20</volume><issue>1</issue><spage>18</spage><epage>25</epage><pages>18-25</pages><issn>1434-7229</issn><eissn>1619-0904</eissn><abstract>Continuous-flow left ventricular assist devices (LVADs) have improved the prognosis of end-stage heart failure. However, continuous-flow LVADs diminish pulsatility, which possibly result in bleeding, aortic insufficiency, and other adverse effects. We previously developed a novel control system for a continuous-flow LVAD (EVAHEART
®
; Sun Medical), and demonstrated that we could create sufficient pulsatility by increasing its rotational speed (RS) in the systolic phase (Pulsatile Mode) in the normal heart model. Here, we aimed to evaluate differences between systolic assist with advanced and delayed loads by shifting the timing of increased RS. We implanted EVAHEART in six goats (55.3 ± 4.3 kg) with normal hearts. We reduced their heart rates to <60 bpm using propranolol and controlled the heart rates at 80 and 120 bpm using ventricular pacing. We shifted the timing of increasing RS from −60 to +60 ms in the systolic phase. We found significant increases in all the following parameters when assessments of delayed timing (+60 ms) were compared with assessments of advanced timing (−60 ms): pulse pressure, mean d
P
/d
t
max of aortic pressure, and energy-equivalent pulse pressure. During continuous-flow LVAD support, pulsatility can be controlled using a rotary pump. In particular, pulsatility can be shifted by delaying increased RS.</abstract><cop>Tokyo</cop><pub>Springer Japan</pub><pmid>27436097</pmid><doi>10.1007/s10047-016-0920-y</doi><tpages>8</tpages></addata></record> |
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| ispartof | Journal of artificial organs, 2017-03, Vol.20 (1), p.18-25 |
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| subjects | Animals Aortic Valve Insufficiency - etiology Biomedical Engineering and Bioengineering Blood Pressure Cardiac Surgery Goats Heart Failure - physiopathology Heart Failure - therapy Heart Rate - physiology Heart Ventricles - physiopathology Heart-Assist Devices - adverse effects Medicine Medicine & Public Health Nephrology Original Article Pulsatile Flow - physiology Systole |
| title | Changing pulsatility by delaying the rotational speed phasing of a rotary left ventricular assist device |
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