Effects of Physical Exercise on Markers of Cellular Immunosenescence: A Systematic Review
Aging affects negatively the immune system, defined as immunosenescence, which increases the susceptibility of elderly persons to infection, autoimmune disease, and cancer. There are strong indications that physical exercise in elderly persons may prevent the age-related decline in immune response w...
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| Veröffentlicht in: | Calcified tissue international 2017-02, Vol.100 (2), p.193-215 |
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| creator | Cao Dinh, H. Beyer, I. Mets, T. Onyema, O. O. Njemini, R. Renmans, W. De Waele, M. Jochmans, K. Vander Meeren, S. Bautmans, I. |
| description | Aging affects negatively the immune system, defined as immunosenescence, which increases the susceptibility of elderly persons to infection, autoimmune disease, and cancer. There are strong indications that physical exercise in elderly persons may prevent the age-related decline in immune response without significant side effects. Consequently, exercise is being considered as a safe mode of intervention to reduce immunosenescence. The aim of this review was to appraise the existing evidence regarding the impact of exercise on surface markers of cellular immunosenescence in either young and old humans or animals. PubMed and Web of Science were systematically screened, and 28 relevant articles in humans or animals were retrieved. Most of the intervention studies demonstrated that an acute bout of exercise induced increases in senescent, naïve, memory CD4
+
and CD8
+
T-lymphocytes and significantly elevated apoptotic lymphocytes in peripheral blood. As regards long-term effects, exercise induced increased levels of T-lymphocytes expressing CD28
+
in both young and elderly subjects. Few studies found an increase in natural killer cell activity following a period of training. We can conclude that exercise has considerable effects on markers of cellular aspects of the immune system. However, very few studies have been conducted so far to investigate the effects of exercise on markers of cellular immunosenescence in elderly persons. Implications for immunosenescence need further investigation. |
| doi_str_mv | 10.1007/s00223-016-0212-9 |
| format | Article |
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+
and CD8
+
T-lymphocytes and significantly elevated apoptotic lymphocytes in peripheral blood. As regards long-term effects, exercise induced increased levels of T-lymphocytes expressing CD28
+
in both young and elderly subjects. Few studies found an increase in natural killer cell activity following a period of training. We can conclude that exercise has considerable effects on markers of cellular aspects of the immune system. However, very few studies have been conducted so far to investigate the effects of exercise on markers of cellular immunosenescence in elderly persons. Implications for immunosenescence need further investigation.</description><identifier>ISSN: 0171-967X</identifier><identifier>EISSN: 1432-0827</identifier><identifier>DOI: 10.1007/s00223-016-0212-9</identifier><identifier>PMID: 27866236</identifier><language>eng</language><publisher>New York: Springer US</publisher><subject>Animals ; Biochemistry ; Biomarkers ; Biomedical and Life Sciences ; Cell Biology ; Endocrinology ; Exercise ; Exercise - physiology ; Humans ; Immune system ; Immunosenescence - physiology ; Life Sciences ; Older people ; Orthopedics ; Physical Conditioning, Animal - physiology ; Review ; Senescence</subject><ispartof>Calcified tissue international, 2017-02, Vol.100 (2), p.193-215</ispartof><rights>Springer Science+Business Media New York 2016</rights><rights>Calcified Tissue International is a copyright of Springer, 2017.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c405t-f756415cfedee7b3ed77f30966602b33dff5f9a53084b8e3bcdf8ee44fb726fd3</citedby><cites>FETCH-LOGICAL-c405t-f756415cfedee7b3ed77f30966602b33dff5f9a53084b8e3bcdf8ee44fb726fd3</cites><orcidid>0000-0002-6820-9586</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://link.springer.com/content/pdf/10.1007/s00223-016-0212-9$$EPDF$$P50$$Gspringer$$H</linktopdf><linktohtml>$$Uhttps://link.springer.com/10.1007/s00223-016-0212-9$$EHTML$$P50$$Gspringer$$H</linktohtml><link.rule.ids>314,776,780,27901,27902,41464,42533,51294</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27866236$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Cao Dinh, H.</creatorcontrib><creatorcontrib>Beyer, I.</creatorcontrib><creatorcontrib>Mets, T.</creatorcontrib><creatorcontrib>Onyema, O. O.</creatorcontrib><creatorcontrib>Njemini, R.</creatorcontrib><creatorcontrib>Renmans, W.</creatorcontrib><creatorcontrib>De Waele, M.</creatorcontrib><creatorcontrib>Jochmans, K.</creatorcontrib><creatorcontrib>Vander Meeren, S.</creatorcontrib><creatorcontrib>Bautmans, I.</creatorcontrib><title>Effects of Physical Exercise on Markers of Cellular Immunosenescence: A Systematic Review</title><title>Calcified tissue international</title><addtitle>Calcif Tissue Int</addtitle><addtitle>Calcif Tissue Int</addtitle><description>Aging affects negatively the immune system, defined as immunosenescence, which increases the susceptibility of elderly persons to infection, autoimmune disease, and cancer. There are strong indications that physical exercise in elderly persons may prevent the age-related decline in immune response without significant side effects. Consequently, exercise is being considered as a safe mode of intervention to reduce immunosenescence. The aim of this review was to appraise the existing evidence regarding the impact of exercise on surface markers of cellular immunosenescence in either young and old humans or animals. PubMed and Web of Science were systematically screened, and 28 relevant articles in humans or animals were retrieved. Most of the intervention studies demonstrated that an acute bout of exercise induced increases in senescent, naïve, memory CD4
+
and CD8
+
T-lymphocytes and significantly elevated apoptotic lymphocytes in peripheral blood. As regards long-term effects, exercise induced increased levels of T-lymphocytes expressing CD28
+
in both young and elderly subjects. Few studies found an increase in natural killer cell activity following a period of training. We can conclude that exercise has considerable effects on markers of cellular aspects of the immune system. However, very few studies have been conducted so far to investigate the effects of exercise on markers of cellular immunosenescence in elderly persons. Implications for immunosenescence need further investigation.</description><subject>Animals</subject><subject>Biochemistry</subject><subject>Biomarkers</subject><subject>Biomedical and Life Sciences</subject><subject>Cell Biology</subject><subject>Endocrinology</subject><subject>Exercise</subject><subject>Exercise - physiology</subject><subject>Humans</subject><subject>Immune system</subject><subject>Immunosenescence - physiology</subject><subject>Life Sciences</subject><subject>Older people</subject><subject>Orthopedics</subject><subject>Physical Conditioning, Animal - physiology</subject><subject>Review</subject><subject>Senescence</subject><issn>0171-967X</issn><issn>1432-0827</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BENPR</sourceid><recordid>eNqNkUtLxDAQx4Mouj4-gBcJePFSzatJ602W9QErig_QU2jTiVb7WJNW3W9v1l1FBMHTHOY3_5nhh9A2JfuUEHXgCWGMR4TKiDDKonQJDajgLCIJU8toQKiiUSrV3Rpa9_6JECqklKtojalESsblAN2PrAXTedxafPk49aXJKjx6B2dKD7ht8HnmnsF99odQVX2VOXxW133TemjAG2gMHOIjfD31HdRZVxp8Ba8lvG2iFZtVHrYWdQPdHo9uhqfR-OLkbHg0jowgcRdZFUtBY2OhAFA5h0Ipy0kaDiUs57ywNrZpFnOSiDwBnpvCJgBC2FwxaQu-gfbmuRPXvvTgO12X4ayqyhpoe69polTCJaf0H6hgsUiEYgHd_YU-tb1rwiOBkiplKedpoOicMq713oHVE1fWmZtqSvRMkZ4r0kGRninSs5mdRXKf11B8T3w5CQCbAz60mgdwP1b_mfoBeQmbSw</recordid><startdate>20170201</startdate><enddate>20170201</enddate><creator>Cao Dinh, H.</creator><creator>Beyer, I.</creator><creator>Mets, T.</creator><creator>Onyema, O. O.</creator><creator>Njemini, R.</creator><creator>Renmans, W.</creator><creator>De Waele, M.</creator><creator>Jochmans, K.</creator><creator>Vander Meeren, S.</creator><creator>Bautmans, I.</creator><general>Springer US</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7QP</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>K9.</scope><scope>KB0</scope><scope>LK8</scope><scope>M0S</scope><scope>M1P</scope><scope>M7P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-6820-9586</orcidid></search><sort><creationdate>20170201</creationdate><title>Effects of Physical Exercise on Markers of Cellular Immunosenescence: A Systematic Review</title><author>Cao Dinh, H. ; Beyer, I. ; Mets, T. ; Onyema, O. O. ; Njemini, R. ; Renmans, W. ; De Waele, M. ; Jochmans, K. ; Vander Meeren, S. ; Bautmans, I.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c405t-f756415cfedee7b3ed77f30966602b33dff5f9a53084b8e3bcdf8ee44fb726fd3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Animals</topic><topic>Biochemistry</topic><topic>Biomarkers</topic><topic>Biomedical and Life Sciences</topic><topic>Cell Biology</topic><topic>Endocrinology</topic><topic>Exercise</topic><topic>Exercise - physiology</topic><topic>Humans</topic><topic>Immune system</topic><topic>Immunosenescence - physiology</topic><topic>Life Sciences</topic><topic>Older people</topic><topic>Orthopedics</topic><topic>Physical Conditioning, Animal - physiology</topic><topic>Review</topic><topic>Senescence</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Cao Dinh, H.</creatorcontrib><creatorcontrib>Beyer, I.</creatorcontrib><creatorcontrib>Mets, T.</creatorcontrib><creatorcontrib>Onyema, O. 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O.</au><au>Njemini, R.</au><au>Renmans, W.</au><au>De Waele, M.</au><au>Jochmans, K.</au><au>Vander Meeren, S.</au><au>Bautmans, I.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Effects of Physical Exercise on Markers of Cellular Immunosenescence: A Systematic Review</atitle><jtitle>Calcified tissue international</jtitle><stitle>Calcif Tissue Int</stitle><addtitle>Calcif Tissue Int</addtitle><date>2017-02-01</date><risdate>2017</risdate><volume>100</volume><issue>2</issue><spage>193</spage><epage>215</epage><pages>193-215</pages><issn>0171-967X</issn><eissn>1432-0827</eissn><abstract>Aging affects negatively the immune system, defined as immunosenescence, which increases the susceptibility of elderly persons to infection, autoimmune disease, and cancer. There are strong indications that physical exercise in elderly persons may prevent the age-related decline in immune response without significant side effects. Consequently, exercise is being considered as a safe mode of intervention to reduce immunosenescence. The aim of this review was to appraise the existing evidence regarding the impact of exercise on surface markers of cellular immunosenescence in either young and old humans or animals. PubMed and Web of Science were systematically screened, and 28 relevant articles in humans or animals were retrieved. Most of the intervention studies demonstrated that an acute bout of exercise induced increases in senescent, naïve, memory CD4
+
and CD8
+
T-lymphocytes and significantly elevated apoptotic lymphocytes in peripheral blood. As regards long-term effects, exercise induced increased levels of T-lymphocytes expressing CD28
+
in both young and elderly subjects. Few studies found an increase in natural killer cell activity following a period of training. We can conclude that exercise has considerable effects on markers of cellular aspects of the immune system. However, very few studies have been conducted so far to investigate the effects of exercise on markers of cellular immunosenescence in elderly persons. Implications for immunosenescence need further investigation.</abstract><cop>New York</cop><pub>Springer US</pub><pmid>27866236</pmid><doi>10.1007/s00223-016-0212-9</doi><tpages>23</tpages><orcidid>https://orcid.org/0000-0002-6820-9586</orcidid></addata></record> |
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| subjects | Animals Biochemistry Biomarkers Biomedical and Life Sciences Cell Biology Endocrinology Exercise Exercise - physiology Humans Immune system Immunosenescence - physiology Life Sciences Older people Orthopedics Physical Conditioning, Animal - physiology Review Senescence |
| title | Effects of Physical Exercise on Markers of Cellular Immunosenescence: A Systematic Review |
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