Dasatinib induces autophagy in mice with Bcr-Abl-positive leukemia

Dasatinib, a second-generation tyrosine kinase inhibitor, is a highly effective treatment for Bcr-Abl-positive leukemia. However, the mechanism by which dasatinib induces cell death is unclear, particularly in vivo. Autophagy is a lysosomal degradation mechanism essential for cell survival and diffe...

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Veröffentlicht in:	International journal of hematology 2017-03, Vol.105 (3), p.335-340
Hauptverfasser:	Morita, Makiko, Nishinaka, Yoko, Kato, Itaru, Saida, Satoshi, Hiramatsu, Hidefumi, Kamikubo, Yasuhiko, Heike, Toshio, Nakahata, Tatsutoshi, Adachi, Souichi
Format:	Artikel
Sprache:	eng
Schlagworte:	Animals Autophagy - drug effects Bone Marrow - pathology Cell Line, Tumor Central Nervous System - pathology Cerebrospinal Fluid Dasatinib - pharmacology Dasatinib - therapeutic use Disease Models, Animal Hematology Humans Leukemia, Myelogenous, Chronic, BCR-ABL Positive - drug therapy Leukemia, Myelogenous, Chronic, BCR-ABL Positive - pathology Leukemic Infiltration - drug therapy Medicine Medicine & Public Health Mice Oncology Original Article
Online-Zugang:	Volltext
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