Rational Design of a Transferrin-Binding Peptide Sequence Tailored to Targeted Nanoparticle Internalization

The transferrin receptor (TfR) is a promising target in cancer therapy owing to its overexpression in most solid tumors and on the blood–brain barrier. Nanostructures chemically derivatized with transferrin are employed in TfR targeting but often lose their functionality upon injection in the bloods...

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Veröffentlicht in:	Bioconjugate chemistry 2017-02, Vol.28 (2), p.471-480
Hauptverfasser:	Santi, Melissa, Maccari, Giuseppe, Mereghetti, Paolo, Voliani, Valerio, Rocchiccioli, Silvia, Ucciferri, Nadia, Luin, Stefano, Signore, Giovanni
Format:	Artikel
Sprache:	eng
Schlagworte:	Adsorption Algorithms Amino Acid Sequence Binding sites Cell Line, Tumor Endocytosis Gold - chemistry Gold - metabolism Humans Models, Molecular Nanoparticles Nanoparticles - chemistry Nanoparticles - metabolism Peptides Peptides - chemistry Peptides - metabolism Protein Binding Protein Corona - chemistry Protein Corona - metabolism Proteins Quantitative Structure-Activity Relationship Receptors, Transferrin - metabolism Transferrin - chemistry Transferrin - metabolism
Online-Zugang:	Volltext
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