PASylation technology improves recombinant interferon- beta 1b solubility, stability, and biological activity

Recombinant interferon- beta 1b (IFN- beta 1b) is an effective remedy against multiple sclerosis and other diseases. However, use of small polypeptide (molecular weight is around 18.5 kDa) is limited due to poor solubility, stability, and short half-life in systemic circulation. To solve this proble...

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Veröffentlicht in:	Applied microbiology and biotechnology 2017-03, Vol.101 (5), p.1975-1987
Hauptverfasser:	Zvonova, Elizaveta A, Ershov, Alexander V, Ershova, Olga A, Sudomoina, Marina A, Degterev, Maksim B, Poroshin, Grigoriy N, Eremeev, Artem V, Karpov, Andrey P, Vishnevsky, Alexander Yu, Goldenkova-Pavlova, Irina V, Petrov, Andrei V, Ruchko, Sergey V, Shuster, Alexander M
Format:	Artikel
Sprache:	eng
Online-Zugang:	Volltext
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