Lenalidomide long-term neurotoxicity: Clinical and neurophysiologic prospective study

OBJECTIVE:To evaluate long-term lenalidomide neurotoxicity and correlation with cumulative dose and hematologic response. METHODS:Nineteen myeloma patients (7 men, mean age 63.2 years) underwent clinical and neurophysiologic assessment at baseline and at 2 (8 patients, group A) or 5 years (11 patien...

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Veröffentlicht in:	Neurology 2016-09, Vol.87 (11), p.1161-1166
Hauptverfasser:	Dalla Torre, Chiara, Zambello, Renato, Cacciavillani, Mario, Campagnolo, Marta, Berno, Tamara, Salvalaggio, Alessandro, De March, Elena, Barilà, Gregorio, Lico, Albano, Lucchetta, Marta, Ermani, Mario, Briani, Chiara
Format:	Artikel
Sprache:	eng
Schlagworte:	Adult Aged Aged, 80 and over Angiogenesis Inhibitors - adverse effects Angiogenesis Inhibitors - therapeutic use Dose-Response Relationship, Drug Drug Resistance, Neoplasm Female Follow-Up Studies Humans Male Middle Aged Multiple Myeloma - drug therapy Neurotoxicity Syndromes - physiopathology Peripheral Nervous System Diseases - etiology Peripheral Nervous System Diseases - physiopathology Prospective Studies Recurrence Sensory Receptor Cells - drug effects Sensory Receptor Cells - physiology Severity of Illness Index Thalidomide - adverse effects Thalidomide - analogs & derivatives Thalidomide - therapeutic use Time Factors
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