Diagnosis of Human Prion Disease Using Real-Time Quaking-Induced Conversion Testing of Olfactory Mucosa and Cerebrospinal Fluid Samples

IMPORTANCE: Early and accurate in vivo diagnosis of Creutzfeldt-Jakob disease (CJD) is necessary for quickly distinguishing treatable from untreatable rapidly progressive dementias and for future therapeutic trials. This early diagnosis is becoming possible using the real-time quaking-induced conver...

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Veröffentlicht in:	JAMA neurology 2017-02, Vol.74 (2), p.155-162
Hauptverfasser:	Bongianni, Matilde, Orrù, Christina, Groveman, Bradley R, Sacchetto, Luca, Fiorini, Michele, Tonoli, Giovanni, Triva, Giorgio, Capaldi, Stefano, Testi, Silvia, Ferrari, Sergio, Cagnin, Annachiara, Ladogana, Anna, Poleggi, Anna, Colaizzo, Elisa, Tiple, Dorina, Vaianella, Luana, Castriciano, Santina, Marchioni, Daniele, Hughson, Andrew G, Imperiale, Daniele, Cattaruzza, Tatiana, Fabrizi, Gian Maria, Pocchiari, Maurizio, Monaco, Salvatore, Caughey, Byron, Zanusso, Gianluigi
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Algorithms Case-Control Studies Creutzfeldt-Jakob Syndrome - cerebrospinal fluid Creutzfeldt-Jakob Syndrome - diagnosis Creutzfeldt-Jakob Syndrome - pathology Female Humans Italy Male Middle Aged Olfactory Mucosa - metabolism Olfactory Mucosa - pathology Prions - cerebrospinal fluid Sensitivity and Specificity
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