Fetuin‐A, serum amyloid A and tumor necrosis factor alpha levels in periodontal health and disease
Objectives This study is evaluating fetuin‐A, serum amyloid A (SAA) and tumor necrosis factor alpha (TNF‐α) levels in gingival crevicular fluid (GCF) and serum samples in periodontal health and disease. Material and Methods Sixty patients were divided into three groups: Group 1 periodontal health (n...
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| Veröffentlicht in: | Oral diseases 2017-04, Vol.23 (3), p.379-386 |
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| creator | Tuerer, C C Balli, U Gueven, B |
| description | Objectives
This study is evaluating fetuin‐A, serum amyloid A (SAA) and tumor necrosis factor alpha (TNF‐α) levels in gingival crevicular fluid (GCF) and serum samples in periodontal health and disease.
Material and Methods
Sixty patients were divided into three groups: Group 1 periodontal health (n = 20), Group 2 gingivitis (n = 20) and Group 3 chronic periodontitis (CP) (n = 20). GCF and serum samples were evaluated using enzyme‐linked immunosorbent assay kit.
Results
SAA and TNF‐α levels in GCF and serum were significantly higher in patients with gingivitis and CP compared with controls (P |
| doi_str_mv | 10.1111/odi.12625 |
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This study is evaluating fetuin‐A, serum amyloid A (SAA) and tumor necrosis factor alpha (TNF‐α) levels in gingival crevicular fluid (GCF) and serum samples in periodontal health and disease.
Material and Methods
Sixty patients were divided into three groups: Group 1 periodontal health (n = 20), Group 2 gingivitis (n = 20) and Group 3 chronic periodontitis (CP) (n = 20). GCF and serum samples were evaluated using enzyme‐linked immunosorbent assay kit.
Results
SAA and TNF‐α levels in GCF and serum were significantly higher in patients with gingivitis and CP compared with controls (P < 0.016). Contrarily, fetuin‐A levels in GCF and serum were significantly higher in controls than in patients with gingivitis and CP (P < 0.016). In CP group, a significant correlation was observed between GCF‐SAA amount and the number of sites with 4 ≤ PPD ≤ 5 mm (P < 0.05). There was a significant correlation between GCF‐fetuin‐A levels and the number of sites with PPD ≥ 6 mm (P < 0.05). GCF‐TNF‐α was found to have a significant relationship with the number of sites with 4 ≤ PPD ≤ 5 mm and PPD ≥ 6 mm (P < 0.05).
Conclusions
In conclusion, serum and total levels of SAA significantly increased, whereas fetuin‐A levels significantly decreased, with increasing severity of PD.</description><identifier>ISSN: 1354-523X</identifier><identifier>EISSN: 1601-0825</identifier><identifier>DOI: 10.1111/odi.12625</identifier><identifier>PMID: 27998014</identifier><language>eng</language><publisher>Denmark: Wiley Subscription Services, Inc</publisher><subject>Adult ; alpha-2-HS-Glycoprotein - metabolism ; Case-Control Studies ; Chronic Disease ; Dentistry ; Female ; Fetuin‐A ; Gangrene ; gingival crevicular fluid ; Gingival Crevicular Fluid - metabolism ; Gingivitis - metabolism ; Gum disease ; Humans ; Male ; Middle Aged ; periodontal disease ; Periodontitis - metabolism ; serum ; serum amyloid A ; Serum Amyloid A Protein - metabolism ; Severity of Illness Index ; Tumor Necrosis Factor-alpha - blood ; Tumor Necrosis Factor-alpha - metabolism ; Tumor necrosis factor-TNF</subject><ispartof>Oral diseases, 2017-04, Vol.23 (3), p.379-386</ispartof><rights>2016 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd</rights><rights>2016 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.</rights><rights>Copyright © 2017 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4525-a85221057b04f70e5dfdf2dde21f7f45bdc6eab6be38b6a1df52743bed6e21683</citedby><cites>FETCH-LOGICAL-c4525-a85221057b04f70e5dfdf2dde21f7f45bdc6eab6be38b6a1df52743bed6e21683</cites><orcidid>0000-0003-3856-4218</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fodi.12625$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fodi.12625$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>315,781,785,1418,27929,27930,45579,45580</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27998014$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Tuerer, C C</creatorcontrib><creatorcontrib>Balli, U</creatorcontrib><creatorcontrib>Gueven, B</creatorcontrib><title>Fetuin‐A, serum amyloid A and tumor necrosis factor alpha levels in periodontal health and disease</title><title>Oral diseases</title><addtitle>Oral Dis</addtitle><description>Objectives
This study is evaluating fetuin‐A, serum amyloid A (SAA) and tumor necrosis factor alpha (TNF‐α) levels in gingival crevicular fluid (GCF) and serum samples in periodontal health and disease.
Material and Methods
Sixty patients were divided into three groups: Group 1 periodontal health (n = 20), Group 2 gingivitis (n = 20) and Group 3 chronic periodontitis (CP) (n = 20). GCF and serum samples were evaluated using enzyme‐linked immunosorbent assay kit.
Results
SAA and TNF‐α levels in GCF and serum were significantly higher in patients with gingivitis and CP compared with controls (P < 0.016). Contrarily, fetuin‐A levels in GCF and serum were significantly higher in controls than in patients with gingivitis and CP (P < 0.016). In CP group, a significant correlation was observed between GCF‐SAA amount and the number of sites with 4 ≤ PPD ≤ 5 mm (P < 0.05). There was a significant correlation between GCF‐fetuin‐A levels and the number of sites with PPD ≥ 6 mm (P < 0.05). GCF‐TNF‐α was found to have a significant relationship with the number of sites with 4 ≤ PPD ≤ 5 mm and PPD ≥ 6 mm (P < 0.05).
Conclusions
In conclusion, serum and total levels of SAA significantly increased, whereas fetuin‐A levels significantly decreased, with increasing severity of PD.</description><subject>Adult</subject><subject>alpha-2-HS-Glycoprotein - metabolism</subject><subject>Case-Control Studies</subject><subject>Chronic Disease</subject><subject>Dentistry</subject><subject>Female</subject><subject>Fetuin‐A</subject><subject>Gangrene</subject><subject>gingival crevicular fluid</subject><subject>Gingival Crevicular Fluid - metabolism</subject><subject>Gingivitis - metabolism</subject><subject>Gum disease</subject><subject>Humans</subject><subject>Male</subject><subject>Middle Aged</subject><subject>periodontal disease</subject><subject>Periodontitis - metabolism</subject><subject>serum</subject><subject>serum amyloid A</subject><subject>Serum Amyloid A Protein - metabolism</subject><subject>Severity of Illness Index</subject><subject>Tumor Necrosis Factor-alpha - blood</subject><subject>Tumor Necrosis Factor-alpha - metabolism</subject><subject>Tumor necrosis factor-TNF</subject><issn>1354-523X</issn><issn>1601-0825</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkc9KxDAQh4Mo_lk9-AIS8KJgNUmbpntcVlcXBC8K3kraTNgsabMmrbI3H8Fn9EnMuupBEMxlMvDNBzM_hA4pOafxXThlzinLGd9AuzQnNCEF45vxn_Is4Sx93EF7IcwJoWKYsm20w8RwWBCa7SI1ga437fvr2-gMB_B9g2WztM4oPMKyVbjrG-dxC7V3wQSsZd3FXtrFTGILz2ADNi1egDdOubaTFs9A2m72OaxMABlgH21paQMcfNUBephc3Y9vktu76-l4dJvUGWc8kQVnjBIuKpJpQYArrTRTChjVQme8UnUOssorSIsql1RpzkSWVqDyiORFOkAna-_Cu6ceQlc2JtRgrWzB9aGkhRAFo0NC_oFymhLGycp6_Audu963cZGVMBOUkSKP1OmaWh0qeNDlwptG-mVJSblKqYwplZ8pRfboy9hXDagf8juWCFysgRdjYfm3qby7nK6VH3KvnBo</recordid><startdate>201704</startdate><enddate>201704</enddate><creator>Tuerer, C C</creator><creator>Balli, U</creator><creator>Gueven, B</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>K9.</scope><scope>7X8</scope><scope>7T5</scope><scope>H94</scope><orcidid>https://orcid.org/0000-0003-3856-4218</orcidid></search><sort><creationdate>201704</creationdate><title>Fetuin‐A, serum amyloid A and tumor necrosis factor alpha levels in periodontal health and disease</title><author>Tuerer, C C ; Balli, U ; Gueven, B</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4525-a85221057b04f70e5dfdf2dde21f7f45bdc6eab6be38b6a1df52743bed6e21683</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Adult</topic><topic>alpha-2-HS-Glycoprotein - metabolism</topic><topic>Case-Control Studies</topic><topic>Chronic Disease</topic><topic>Dentistry</topic><topic>Female</topic><topic>Fetuin‐A</topic><topic>Gangrene</topic><topic>gingival crevicular fluid</topic><topic>Gingival Crevicular Fluid - metabolism</topic><topic>Gingivitis - metabolism</topic><topic>Gum disease</topic><topic>Humans</topic><topic>Male</topic><topic>Middle Aged</topic><topic>periodontal disease</topic><topic>Periodontitis - metabolism</topic><topic>serum</topic><topic>serum amyloid A</topic><topic>Serum Amyloid A Protein - metabolism</topic><topic>Severity of Illness Index</topic><topic>Tumor Necrosis Factor-alpha - blood</topic><topic>Tumor Necrosis Factor-alpha - metabolism</topic><topic>Tumor necrosis factor-TNF</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Tuerer, C C</creatorcontrib><creatorcontrib>Balli, U</creatorcontrib><creatorcontrib>Gueven, B</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><jtitle>Oral diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Tuerer, C C</au><au>Balli, U</au><au>Gueven, B</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Fetuin‐A, serum amyloid A and tumor necrosis factor alpha levels in periodontal health and disease</atitle><jtitle>Oral diseases</jtitle><addtitle>Oral Dis</addtitle><date>2017-04</date><risdate>2017</risdate><volume>23</volume><issue>3</issue><spage>379</spage><epage>386</epage><pages>379-386</pages><issn>1354-523X</issn><eissn>1601-0825</eissn><abstract>Objectives
This study is evaluating fetuin‐A, serum amyloid A (SAA) and tumor necrosis factor alpha (TNF‐α) levels in gingival crevicular fluid (GCF) and serum samples in periodontal health and disease.
Material and Methods
Sixty patients were divided into three groups: Group 1 periodontal health (n = 20), Group 2 gingivitis (n = 20) and Group 3 chronic periodontitis (CP) (n = 20). GCF and serum samples were evaluated using enzyme‐linked immunosorbent assay kit.
Results
SAA and TNF‐α levels in GCF and serum were significantly higher in patients with gingivitis and CP compared with controls (P < 0.016). Contrarily, fetuin‐A levels in GCF and serum were significantly higher in controls than in patients with gingivitis and CP (P < 0.016). In CP group, a significant correlation was observed between GCF‐SAA amount and the number of sites with 4 ≤ PPD ≤ 5 mm (P < 0.05). There was a significant correlation between GCF‐fetuin‐A levels and the number of sites with PPD ≥ 6 mm (P < 0.05). GCF‐TNF‐α was found to have a significant relationship with the number of sites with 4 ≤ PPD ≤ 5 mm and PPD ≥ 6 mm (P < 0.05).
Conclusions
In conclusion, serum and total levels of SAA significantly increased, whereas fetuin‐A levels significantly decreased, with increasing severity of PD.</abstract><cop>Denmark</cop><pub>Wiley Subscription Services, Inc</pub><pmid>27998014</pmid><doi>10.1111/odi.12625</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0003-3856-4218</orcidid></addata></record> |
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| subjects | Adult alpha-2-HS-Glycoprotein - metabolism Case-Control Studies Chronic Disease Dentistry Female Fetuin‐A Gangrene gingival crevicular fluid Gingival Crevicular Fluid - metabolism Gingivitis - metabolism Gum disease Humans Male Middle Aged periodontal disease Periodontitis - metabolism serum serum amyloid A Serum Amyloid A Protein - metabolism Severity of Illness Index Tumor Necrosis Factor-alpha - blood Tumor Necrosis Factor-alpha - metabolism Tumor necrosis factor-TNF |
| title | Fetuin‐A, serum amyloid A and tumor necrosis factor alpha levels in periodontal health and disease |
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