Cutaneous side effects of TNF‐alpha inhibitors
Summary Since the early 1990s, tumor necrosis factor alpha (TNF‐alpha) inhibitors have been successfully used in the treatment of various immune‐mediated inflammatory diseases. By now, comprehensive safety data has been compiled. While adverse reactions do occur, they are – in relation to the freque...
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| Veröffentlicht in: | Journal der Deutschen Dermatologischen Gesellschaft 2017-03, Vol.15 (3), p.281-288 |
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| container_title | Journal der Deutschen Dermatologischen Gesellschaft |
| container_volume | 15 |
| creator | Lindhaus, Claudia Tittelbach, Jörg Elsner, Peter |
| description | Summary
Since the early 1990s, tumor necrosis factor alpha (TNF‐alpha) inhibitors have been successfully used in the treatment of various immune‐mediated inflammatory diseases. By now, comprehensive safety data has been compiled. While adverse reactions do occur, they are – in relation to the frequent use of these agents – rare and usually not serious. Cutaneous side effects include local injection site reactions, infections, immune‐mediated reactions, and neoplasms. The most common serious adverse events are of an infectious nature. Mycobacteria but also non‐mycobacterial pathogens, such as viruses and fungi, may cause serious, even lethal, systemic infections. The present article is meant to review current knowledge with respect to cutaneous side effects of TNF‐alpha inhibitors. |
| doi_str_mv | 10.1111/ddg.13200 |
| format | Article |
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Since the early 1990s, tumor necrosis factor alpha (TNF‐alpha) inhibitors have been successfully used in the treatment of various immune‐mediated inflammatory diseases. By now, comprehensive safety data has been compiled. While adverse reactions do occur, they are – in relation to the frequent use of these agents – rare and usually not serious. Cutaneous side effects include local injection site reactions, infections, immune‐mediated reactions, and neoplasms. The most common serious adverse events are of an infectious nature. Mycobacteria but also non‐mycobacterial pathogens, such as viruses and fungi, may cause serious, even lethal, systemic infections. The present article is meant to review current knowledge with respect to cutaneous side effects of TNF‐alpha inhibitors.</description><identifier>ISSN: 1610-0379</identifier><identifier>EISSN: 1610-0387</identifier><identifier>DOI: 10.1111/ddg.13200</identifier><identifier>PMID: 28252861</identifier><language>eng</language><publisher>Germany: Wiley Subscription Services, Inc</publisher><subject>Anti-Inflammatory Agents, Non-Steroidal - adverse effects ; Dose-Response Relationship, Drug ; Drug Eruptions - diagnosis ; Drug Eruptions - etiology ; Drug Eruptions - prevention & control ; Evidence-Based Medicine ; Humans ; Immunosuppressive Agents - adverse effects ; Psoriasis - chemically induced ; Psoriasis - diagnosis ; Psoriasis - prevention & control ; Risk Factors ; Skin Diseases, Infectious - chemically induced ; Skin Diseases, Infectious - diagnosis ; Skin Diseases, Infectious - prevention & control ; Skin Neoplasms - chemically induced ; Skin Neoplasms - diagnosis ; Skin Neoplasms - prevention & control ; Treatment Outcome ; Tumor Necrosis Factor-alpha - antagonists & inhibitors</subject><ispartof>Journal der Deutschen Dermatologischen Gesellschaft, 2017-03, Vol.15 (3), p.281-288</ispartof><rights>2017 Deutsche Dermatologische Gesellschaft (DDG). Published by John Wiley & Sons Ltd.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4210-b4ccdb948c241e8d8fcb8affb41aad6b33864735df540d620440937da98821b53</citedby><cites>FETCH-LOGICAL-c4210-b4ccdb948c241e8d8fcb8affb41aad6b33864735df540d620440937da98821b53</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fddg.13200$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fddg.13200$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>315,781,785,1418,27929,27930,45579,45580</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28252861$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Lindhaus, Claudia</creatorcontrib><creatorcontrib>Tittelbach, Jörg</creatorcontrib><creatorcontrib>Elsner, Peter</creatorcontrib><title>Cutaneous side effects of TNF‐alpha inhibitors</title><title>Journal der Deutschen Dermatologischen Gesellschaft</title><addtitle>J Dtsch Dermatol Ges</addtitle><description>Summary
Since the early 1990s, tumor necrosis factor alpha (TNF‐alpha) inhibitors have been successfully used in the treatment of various immune‐mediated inflammatory diseases. By now, comprehensive safety data has been compiled. While adverse reactions do occur, they are – in relation to the frequent use of these agents – rare and usually not serious. Cutaneous side effects include local injection site reactions, infections, immune‐mediated reactions, and neoplasms. The most common serious adverse events are of an infectious nature. Mycobacteria but also non‐mycobacterial pathogens, such as viruses and fungi, may cause serious, even lethal, systemic infections. The present article is meant to review current knowledge with respect to cutaneous side effects of TNF‐alpha inhibitors.</description><subject>Anti-Inflammatory Agents, Non-Steroidal - adverse effects</subject><subject>Dose-Response Relationship, Drug</subject><subject>Drug Eruptions - diagnosis</subject><subject>Drug Eruptions - etiology</subject><subject>Drug Eruptions - prevention & control</subject><subject>Evidence-Based Medicine</subject><subject>Humans</subject><subject>Immunosuppressive Agents - adverse effects</subject><subject>Psoriasis - chemically induced</subject><subject>Psoriasis - diagnosis</subject><subject>Psoriasis - prevention & control</subject><subject>Risk Factors</subject><subject>Skin Diseases, Infectious - chemically induced</subject><subject>Skin Diseases, Infectious - diagnosis</subject><subject>Skin Diseases, Infectious - prevention & control</subject><subject>Skin Neoplasms - chemically induced</subject><subject>Skin Neoplasms - diagnosis</subject><subject>Skin Neoplasms - prevention & control</subject><subject>Treatment Outcome</subject><subject>Tumor Necrosis Factor-alpha - antagonists & inhibitors</subject><issn>1610-0379</issn><issn>1610-0387</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqN0LtOwzAUBmALgWgpDLwAisQCQ9vjSxJnRC0tSBUsZbZ8panSpsSJUDcegWfkSTBNYUBCwos9fPrP8Y_QOYYBDmdozPMAUwJwgLo4wdAHytPDn3eaddCJ90sAEnOAY9QhnMSEJ7iLYNTUcm3Lxkc-Nzayzlld-6h00fxh8vH2LovNQkb5epGrvC4rf4qOnCy8PdvfPfQ0uZ2P7vqzx-n96GbW14yEqYppbVTGuCYMW26404pL5xTDUppEUcoTltLYuJiBSQgwBhlNjcw4J1jFtIeu2txNVb401tdilXtti6LdVmCephxnSQL_oTQllMUs0MtfdFk21Tp8ZKdoTBjgoK5bpavS-8o6sanylay2AoP4alyExsWu8WAv9omNWlnzI78rDmDYgte8sNu_k8R4PG0jPwFWVYeq</recordid><startdate>201703</startdate><enddate>201703</enddate><creator>Lindhaus, Claudia</creator><creator>Tittelbach, Jörg</creator><creator>Elsner, Peter</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>7X8</scope><scope>M7N</scope></search><sort><creationdate>201703</creationdate><title>Cutaneous side effects of TNF‐alpha inhibitors</title><author>Lindhaus, Claudia ; Tittelbach, Jörg ; Elsner, Peter</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4210-b4ccdb948c241e8d8fcb8affb41aad6b33864735df540d620440937da98821b53</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Anti-Inflammatory Agents, Non-Steroidal - adverse effects</topic><topic>Dose-Response Relationship, Drug</topic><topic>Drug Eruptions - diagnosis</topic><topic>Drug Eruptions - etiology</topic><topic>Drug Eruptions - prevention & control</topic><topic>Evidence-Based Medicine</topic><topic>Humans</topic><topic>Immunosuppressive Agents - adverse effects</topic><topic>Psoriasis - chemically induced</topic><topic>Psoriasis - diagnosis</topic><topic>Psoriasis - prevention & control</topic><topic>Risk Factors</topic><topic>Skin Diseases, Infectious - chemically induced</topic><topic>Skin Diseases, Infectious - diagnosis</topic><topic>Skin Diseases, Infectious - prevention & control</topic><topic>Skin Neoplasms - chemically induced</topic><topic>Skin Neoplasms - diagnosis</topic><topic>Skin Neoplasms - prevention & control</topic><topic>Treatment Outcome</topic><topic>Tumor Necrosis Factor-alpha - antagonists & inhibitors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Lindhaus, Claudia</creatorcontrib><creatorcontrib>Tittelbach, Jörg</creatorcontrib><creatorcontrib>Elsner, Peter</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>MEDLINE - Academic</collection><collection>Algology Mycology and Protozoology Abstracts (Microbiology C)</collection><jtitle>Journal der Deutschen Dermatologischen Gesellschaft</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Lindhaus, Claudia</au><au>Tittelbach, Jörg</au><au>Elsner, Peter</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Cutaneous side effects of TNF‐alpha inhibitors</atitle><jtitle>Journal der Deutschen Dermatologischen Gesellschaft</jtitle><addtitle>J Dtsch Dermatol Ges</addtitle><date>2017-03</date><risdate>2017</risdate><volume>15</volume><issue>3</issue><spage>281</spage><epage>288</epage><pages>281-288</pages><issn>1610-0379</issn><eissn>1610-0387</eissn><abstract>Summary
Since the early 1990s, tumor necrosis factor alpha (TNF‐alpha) inhibitors have been successfully used in the treatment of various immune‐mediated inflammatory diseases. By now, comprehensive safety data has been compiled. While adverse reactions do occur, they are – in relation to the frequent use of these agents – rare and usually not serious. Cutaneous side effects include local injection site reactions, infections, immune‐mediated reactions, and neoplasms. The most common serious adverse events are of an infectious nature. Mycobacteria but also non‐mycobacterial pathogens, such as viruses and fungi, may cause serious, even lethal, systemic infections. The present article is meant to review current knowledge with respect to cutaneous side effects of TNF‐alpha inhibitors.</abstract><cop>Germany</cop><pub>Wiley Subscription Services, Inc</pub><pmid>28252861</pmid><doi>10.1111/ddg.13200</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
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| subjects | Anti-Inflammatory Agents, Non-Steroidal - adverse effects Dose-Response Relationship, Drug Drug Eruptions - diagnosis Drug Eruptions - etiology Drug Eruptions - prevention & control Evidence-Based Medicine Humans Immunosuppressive Agents - adverse effects Psoriasis - chemically induced Psoriasis - diagnosis Psoriasis - prevention & control Risk Factors Skin Diseases, Infectious - chemically induced Skin Diseases, Infectious - diagnosis Skin Diseases, Infectious - prevention & control Skin Neoplasms - chemically induced Skin Neoplasms - diagnosis Skin Neoplasms - prevention & control Treatment Outcome Tumor Necrosis Factor-alpha - antagonists & inhibitors |
| title | Cutaneous side effects of TNF‐alpha inhibitors |
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