Alanine substitutions in the GXXXG motif alter C99 cleavage by γ‐secretase but not its dimerization

The amyloid β (Aβ) protein is a major component of senile plaques, one of the neuropathological hallmarks of Alzheimer's disease. Amyloidogenic processing of amyloid precursor protein (APP) by β‐ and γ‐secretases leads to production of Aβ. APP contains tandem triple repeats of the GXXXG motif i...

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Veröffentlicht in:	Journal of neurochemistry 2017-03, Vol.140 (6), p.955-962
Hauptverfasser:	Higashide, Hidekazu, Ishihara, Seiko, Nobuhara, Mika, Ihara, Yasuo, Funamoto, Satoru
Format:	Artikel
Sprache:	eng
Schlagworte:	Alanine - genetics Alanine - metabolism Alzheimer disease Amino Acid Motifs - physiology Amino Acid Sequence Amino Acid Substitution - physiology Amyloid beta-Peptides - genetics Amyloid beta-Peptides - metabolism Amyloid beta-Protein Precursor - metabolism Amyloid Precursor Protein Secretases - metabolism amyloid‐β Animals CHO Cells Cricetinae Cricetulus dimerization enzyme processing gamma‐secretase Humans Insecta Peptide Fragments - metabolism Protein Multimerization - physiology transmembrane domain
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