Predicting Alzheimer disease from a blood-based biomarker profile: A 54-month follow-up

OBJECTIVE:We assessed a blood-based signature, which previously demonstrated high accuracy at stratifying individuals with high or low neocortical β-amyloid burden (NAB), to determine whether it could also identify individuals at risk of progression to Alzheimer disease (AD) within 54 months. METHOD...

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Veröffentlicht in:	Neurology 2016-09, Vol.87 (11), p.1093-1101
Hauptverfasser:	Burnham, Samantha C, Rowe, Christopher C, Baker, David, Bush, Ashley I, Doecke, James D, Faux, Noel G, Laws, Simon M, Martins, Ralph N, Maruff, Paul, Macaulay, S Lance, Rainey-Smith, Stephanie, Savage, Greg, Ames, David, Masters, Colin L, Wilson, William, Villemagne, Victor L
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Aged, 80 and over Alzheimer Disease - blood Alzheimer Disease - diagnostic imaging Alzheimer Disease - psychology Amyloid beta-Peptides - metabolism Analysis of Variance Biomarkers - blood Blood Chemical Analysis Brain - diagnostic imaging Brain - metabolism Cognition Cognitive Dysfunction - blood Cognitive Dysfunction - diagnostic imaging Cognitive Dysfunction - psychology Disease Progression Female Follow-Up Studies Humans Linear Models Male Neuropsychological Tests Odds Ratio Positron-Emission Tomography
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