Immunoglobulin G4‐related disease and its skin manifestations
Immunoglobulin G4‐related disease (IgG4‐RD) is a systemic inflammatory condition characterized by tissue infiltration with IgG4+ plasma cells and an elevated serum IgG4 level. It usually occurs in middle‐aged or older patients, with male predominance, and can involve multiple organs synchronously or...
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| Veröffentlicht in: | Journal of dermatology 2017-03, Vol.44 (3), p.288-296 |
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| creator | Takayama, Ryoko Ueno, Takashi Saeki, Hidehisa |
| description | Immunoglobulin G4‐related disease (IgG4‐RD) is a systemic inflammatory condition characterized by tissue infiltration with IgG4+ plasma cells and an elevated serum IgG4 level. It usually occurs in middle‐aged or older patients, with male predominance, and can involve multiple organs synchronously or metachronously. Patients with IgG4‐RD generally respond to steroid therapy. IgG4‐related skin lesions are typically erythematous and itchy plaques, subcutaneous nodules, or papules like prurigo nodularis located on the head and neck areas. Histologically, lymphoplasmacytic infiltrates with abundant IgG4+ plasma cells are seen in the dermis and/or subcutaneous tissue. The skin condition of IgG4‐RD does not necessarily exhibit infiltration of IgG4+ plasma cells, which is a prerequisite for IgG4‐related skin disease, but such skin lesions without infiltration by IgG4+ plasma cells can be included in the skin manifestations of IgG4‐RD. |
| doi_str_mv | 10.1111/1346-8138.13723 |
| format | Article |
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It usually occurs in middle‐aged or older patients, with male predominance, and can involve multiple organs synchronously or metachronously. Patients with IgG4‐RD generally respond to steroid therapy. IgG4‐related skin lesions are typically erythematous and itchy plaques, subcutaneous nodules, or papules like prurigo nodularis located on the head and neck areas. Histologically, lymphoplasmacytic infiltrates with abundant IgG4+ plasma cells are seen in the dermis and/or subcutaneous tissue. The skin condition of IgG4‐RD does not necessarily exhibit infiltration of IgG4+ plasma cells, which is a prerequisite for IgG4‐related skin disease, but such skin lesions without infiltration by IgG4+ plasma cells can be included in the skin manifestations of IgG4‐RD.</description><identifier>ISSN: 0385-2407</identifier><identifier>EISSN: 1346-8138</identifier><identifier>DOI: 10.1111/1346-8138.13723</identifier><identifier>PMID: 28256769</identifier><language>eng</language><publisher>England: Wiley Subscription Services, Inc</publisher><subject>Genes ; Humans ; hypergammaglobulinemia ; Hypergammaglobulinemia - complications ; Hypergammaglobulinemia - immunology ; Immunoglobulin G - immunology ; immunoglobulin G4‐related disease ; immunoglobulin G4‐related skin disease ; Immunoglobulins ; leukocytoclastic vasculitis ; Plasma ; skin ; Skin Diseases - diagnosis ; Skin Diseases - etiology ; Skin Diseases - immunology</subject><ispartof>Journal of dermatology, 2017-03, Vol.44 (3), p.288-296</ispartof><rights>2017 Japanese Dermatological Association</rights><rights>2017 Japanese Dermatological Association.</rights><rights>Copyright © 2017 Japanese Dermatological Association</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c5353-eb7ff247c622680451f855af474f22372e7e7b8bf5f3fab07b04523a05c68a8a3</citedby><cites>FETCH-LOGICAL-c5353-eb7ff247c622680451f855af474f22372e7e7b8bf5f3fab07b04523a05c68a8a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2F1346-8138.13723$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2F1346-8138.13723$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27903,27904,45553,45554</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28256769$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Takayama, Ryoko</creatorcontrib><creatorcontrib>Ueno, Takashi</creatorcontrib><creatorcontrib>Saeki, Hidehisa</creatorcontrib><title>Immunoglobulin G4‐related disease and its skin manifestations</title><title>Journal of dermatology</title><addtitle>J Dermatol</addtitle><description>Immunoglobulin G4‐related disease (IgG4‐RD) is a systemic inflammatory condition characterized by tissue infiltration with IgG4+ plasma cells and an elevated serum IgG4 level. It usually occurs in middle‐aged or older patients, with male predominance, and can involve multiple organs synchronously or metachronously. Patients with IgG4‐RD generally respond to steroid therapy. IgG4‐related skin lesions are typically erythematous and itchy plaques, subcutaneous nodules, or papules like prurigo nodularis located on the head and neck areas. Histologically, lymphoplasmacytic infiltrates with abundant IgG4+ plasma cells are seen in the dermis and/or subcutaneous tissue. The skin condition of IgG4‐RD does not necessarily exhibit infiltration of IgG4+ plasma cells, which is a prerequisite for IgG4‐related skin disease, but such skin lesions without infiltration by IgG4+ plasma cells can be included in the skin manifestations of IgG4‐RD.</description><subject>Genes</subject><subject>Humans</subject><subject>hypergammaglobulinemia</subject><subject>Hypergammaglobulinemia - complications</subject><subject>Hypergammaglobulinemia - immunology</subject><subject>Immunoglobulin G - immunology</subject><subject>immunoglobulin G4‐related disease</subject><subject>immunoglobulin G4‐related skin disease</subject><subject>Immunoglobulins</subject><subject>leukocytoclastic vasculitis</subject><subject>Plasma</subject><subject>skin</subject><subject>Skin Diseases - diagnosis</subject><subject>Skin Diseases - etiology</subject><subject>Skin Diseases - immunology</subject><issn>0385-2407</issn><issn>1346-8138</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqN0btOwzAUBmALgWgpzGwoEgtLiq-xOyFUSimqxAKz5SQ2ckniEidC3XgEnpEnwSGlAwt4sWR9_n18DgCnCI5RWJeI0CQWiIgxIhyTPTDcneyDISSCxZhCPgBH3q8gxBOG4CEYYIFZwpPJEFwtyrKt3HPh0rawVTSnn-8ftS5Uo_Mot14rryNV5ZFtfORfgihVZY32jWqsq_wxODCq8Ppku4_A0-3scXoXLx_mi-n1Ms4YYSTWKTcGU54lGCcCUoaMYEwZyqnBOJSuueapSA0zxKgU8jQYTBRkWSKUUGQELvrcde1e2_C8LK3PdFGoSrvWSyQ4F4hjAf9DKaUkoSjQ81905dq6Ch_pFAnFQsqDuuxVVjvva23kuralqjcSQdmNQXZNl13T5fcYwo2zbW6bljrf-Z--B8B68GYLvfkrT97fzPrgL0VmkBU</recordid><startdate>201703</startdate><enddate>201703</enddate><creator>Takayama, Ryoko</creator><creator>Ueno, Takashi</creator><creator>Saeki, Hidehisa</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>201703</creationdate><title>Immunoglobulin G4‐related disease and its skin manifestations</title><author>Takayama, Ryoko ; Ueno, Takashi ; Saeki, Hidehisa</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c5353-eb7ff247c622680451f855af474f22372e7e7b8bf5f3fab07b04523a05c68a8a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Genes</topic><topic>Humans</topic><topic>hypergammaglobulinemia</topic><topic>Hypergammaglobulinemia - complications</topic><topic>Hypergammaglobulinemia - immunology</topic><topic>Immunoglobulin G - immunology</topic><topic>immunoglobulin G4‐related disease</topic><topic>immunoglobulin G4‐related skin disease</topic><topic>Immunoglobulins</topic><topic>leukocytoclastic vasculitis</topic><topic>Plasma</topic><topic>skin</topic><topic>Skin Diseases - diagnosis</topic><topic>Skin Diseases - etiology</topic><topic>Skin Diseases - immunology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Takayama, Ryoko</creatorcontrib><creatorcontrib>Ueno, Takashi</creatorcontrib><creatorcontrib>Saeki, Hidehisa</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of dermatology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Takayama, Ryoko</au><au>Ueno, Takashi</au><au>Saeki, Hidehisa</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Immunoglobulin G4‐related disease and its skin manifestations</atitle><jtitle>Journal of dermatology</jtitle><addtitle>J Dermatol</addtitle><date>2017-03</date><risdate>2017</risdate><volume>44</volume><issue>3</issue><spage>288</spage><epage>296</epage><pages>288-296</pages><issn>0385-2407</issn><eissn>1346-8138</eissn><abstract>Immunoglobulin G4‐related disease (IgG4‐RD) is a systemic inflammatory condition characterized by tissue infiltration with IgG4+ plasma cells and an elevated serum IgG4 level. It usually occurs in middle‐aged or older patients, with male predominance, and can involve multiple organs synchronously or metachronously. Patients with IgG4‐RD generally respond to steroid therapy. IgG4‐related skin lesions are typically erythematous and itchy plaques, subcutaneous nodules, or papules like prurigo nodularis located on the head and neck areas. Histologically, lymphoplasmacytic infiltrates with abundant IgG4+ plasma cells are seen in the dermis and/or subcutaneous tissue. The skin condition of IgG4‐RD does not necessarily exhibit infiltration of IgG4+ plasma cells, which is a prerequisite for IgG4‐related skin disease, but such skin lesions without infiltration by IgG4+ plasma cells can be included in the skin manifestations of IgG4‐RD.</abstract><cop>England</cop><pub>Wiley Subscription Services, Inc</pub><pmid>28256769</pmid><doi>10.1111/1346-8138.13723</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; Wiley Online Library Journals Frontfile Complete |
| subjects | Genes Humans hypergammaglobulinemia Hypergammaglobulinemia - complications Hypergammaglobulinemia - immunology Immunoglobulin G - immunology immunoglobulin G4‐related disease immunoglobulin G4‐related skin disease Immunoglobulins leukocytoclastic vasculitis Plasma skin Skin Diseases - diagnosis Skin Diseases - etiology Skin Diseases - immunology |
| title | Immunoglobulin G4‐related disease and its skin manifestations |
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