C1q binding is not an independent risk factor for kidney allograft loss after an acute antibody‐mediated rejection episode: a retrospective cohort study
Summary After kidney transplantation, C4d is an incomplete marker of acute antibody‐mediated rejection (AMR) and C1q‐binding donor‐specific antibodies (DSA) have been associated with allograft survival. However, the impact on allograft survival of C1q+ DSA after clinical AMR has not been studied yet...
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| Veröffentlicht in: | Transplant international 2017-03, Vol.30 (3), p.277-287 |
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| creator | Moktefi, Anissa Parisot, Juliette Desvaux, Dominique Canoui‐Poitrine, Florence Brocheriou, Isabelle Peltier, Julie Audard, Vincent Kofman, Tomek Suberbielle, Caroline Lang, Philippe Rondeau, Eric Grimbert, Philippe Matignon, Marie |
| description | Summary
After kidney transplantation, C4d is an incomplete marker of acute antibody‐mediated rejection (AMR) and C1q‐binding donor‐specific antibodies (DSA) have been associated with allograft survival. However, the impact on allograft survival of C1q+ DSA after clinical AMR has not been studied yet. We analysed retrospectively in clinical AMR C4d staining and C1q‐binding impact on allograft survival. We compared clinical, histological and serological features of C4d− and C4d+ AMR, C1q+ and C1q− DSA AMR and analysed C4d and C1q‐binding impact on allograft survival. Among 500 for‐cause kidney allograft biopsies, 48 fulfilled AMR criteria. C4d+ AMR [N = 18 (37.5%)] have significantly higher number class I DSA (P = 0.02), higher microvascular score (P = 0.02) and more transplant glomerulopathy (P = 0.04). C1q+ AMR [N = 20 (44%)] presented with significantly more class I and class II DSA (P = 0.005 and 0.04) and C4d+ staining (P = 0.01). Graft losses were significantly higher in the C4d+ group (P = 0.04) but similar in C1q groups. C4d+ but not C1q+ binding was an independent risk factor for graft loss [HR = 2.65; (1.11–6.34); P = 0.028]. In our cohort of clinical AMR, C4d+ staining but not C1q+ binding is an independent risk factor for graft loss. Allograft loss and patient survival were similar in C1q+ and C1q− AMR. |
| doi_str_mv | 10.1111/tri.12905 |
| format | Article |
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After kidney transplantation, C4d is an incomplete marker of acute antibody‐mediated rejection (AMR) and C1q‐binding donor‐specific antibodies (DSA) have been associated with allograft survival. However, the impact on allograft survival of C1q+ DSA after clinical AMR has not been studied yet. We analysed retrospectively in clinical AMR C4d staining and C1q‐binding impact on allograft survival. We compared clinical, histological and serological features of C4d− and C4d+ AMR, C1q+ and C1q− DSA AMR and analysed C4d and C1q‐binding impact on allograft survival. Among 500 for‐cause kidney allograft biopsies, 48 fulfilled AMR criteria. C4d+ AMR [N = 18 (37.5%)] have significantly higher number class I DSA (P = 0.02), higher microvascular score (P = 0.02) and more transplant glomerulopathy (P = 0.04). C1q+ AMR [N = 20 (44%)] presented with significantly more class I and class II DSA (P = 0.005 and 0.04) and C4d+ staining (P = 0.01). Graft losses were significantly higher in the C4d+ group (P = 0.04) but similar in C1q groups. C4d+ but not C1q+ binding was an independent risk factor for graft loss [HR = 2.65; (1.11–6.34); P = 0.028]. In our cohort of clinical AMR, C4d+ staining but not C1q+ binding is an independent risk factor for graft loss. Allograft loss and patient survival were similar in C1q+ and C1q− AMR.</description><identifier>ISSN: 0934-0874</identifier><identifier>EISSN: 1432-2277</identifier><identifier>DOI: 10.1111/tri.12905</identifier><identifier>PMID: 27992962</identifier><language>eng</language><publisher>England: Blackwell Publishing Ltd</publisher><subject>Adult ; allograft survival ; antibody‐mediated rejection ; C1q‐binding DSA ; C4d staining ; Cohort Studies ; Complement C1q - metabolism ; Complement C4b - metabolism ; Female ; Graft Rejection - etiology ; Graft Rejection - immunology ; Humans ; Isoantibodies - metabolism ; kidney transplantation ; Kidney Transplantation - adverse effects ; Male ; Middle Aged ; Peptide Fragments - metabolism ; Retrospective Studies ; Risk Factors ; Tissue Donors</subject><ispartof>Transplant international, 2017-03, Vol.30 (3), p.277-287</ispartof><rights>2016 Steunstichting ESOT</rights><rights>2016 Steunstichting ESOT.</rights><rights>Copyright © 2017 Steunstichting ESOT. Published by John Wiley & Sons Ltd</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3365-1658bd757ba7fd1657cd86c8f5b90bbe1ad0f60177a8d5c5d3364641735e6b183</citedby><cites>FETCH-LOGICAL-c3365-1658bd757ba7fd1657cd86c8f5b90bbe1ad0f60177a8d5c5d3364641735e6b183</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Ftri.12905$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Ftri.12905$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27903,27904,45553,45554</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/27992962$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Moktefi, Anissa</creatorcontrib><creatorcontrib>Parisot, Juliette</creatorcontrib><creatorcontrib>Desvaux, Dominique</creatorcontrib><creatorcontrib>Canoui‐Poitrine, Florence</creatorcontrib><creatorcontrib>Brocheriou, Isabelle</creatorcontrib><creatorcontrib>Peltier, Julie</creatorcontrib><creatorcontrib>Audard, Vincent</creatorcontrib><creatorcontrib>Kofman, Tomek</creatorcontrib><creatorcontrib>Suberbielle, Caroline</creatorcontrib><creatorcontrib>Lang, Philippe</creatorcontrib><creatorcontrib>Rondeau, Eric</creatorcontrib><creatorcontrib>Grimbert, Philippe</creatorcontrib><creatorcontrib>Matignon, Marie</creatorcontrib><title>C1q binding is not an independent risk factor for kidney allograft loss after an acute antibody‐mediated rejection episode: a retrospective cohort study</title><title>Transplant international</title><addtitle>Transpl Int</addtitle><description>Summary
After kidney transplantation, C4d is an incomplete marker of acute antibody‐mediated rejection (AMR) and C1q‐binding donor‐specific antibodies (DSA) have been associated with allograft survival. However, the impact on allograft survival of C1q+ DSA after clinical AMR has not been studied yet. We analysed retrospectively in clinical AMR C4d staining and C1q‐binding impact on allograft survival. We compared clinical, histological and serological features of C4d− and C4d+ AMR, C1q+ and C1q− DSA AMR and analysed C4d and C1q‐binding impact on allograft survival. Among 500 for‐cause kidney allograft biopsies, 48 fulfilled AMR criteria. C4d+ AMR [N = 18 (37.5%)] have significantly higher number class I DSA (P = 0.02), higher microvascular score (P = 0.02) and more transplant glomerulopathy (P = 0.04). C1q+ AMR [N = 20 (44%)] presented with significantly more class I and class II DSA (P = 0.005 and 0.04) and C4d+ staining (P = 0.01). Graft losses were significantly higher in the C4d+ group (P = 0.04) but similar in C1q groups. C4d+ but not C1q+ binding was an independent risk factor for graft loss [HR = 2.65; (1.11–6.34); P = 0.028]. In our cohort of clinical AMR, C4d+ staining but not C1q+ binding is an independent risk factor for graft loss. Allograft loss and patient survival were similar in C1q+ and C1q− AMR.</description><subject>Adult</subject><subject>allograft survival</subject><subject>antibody‐mediated rejection</subject><subject>C1q‐binding DSA</subject><subject>C4d staining</subject><subject>Cohort Studies</subject><subject>Complement C1q - metabolism</subject><subject>Complement C4b - metabolism</subject><subject>Female</subject><subject>Graft Rejection - etiology</subject><subject>Graft Rejection - immunology</subject><subject>Humans</subject><subject>Isoantibodies - metabolism</subject><subject>kidney transplantation</subject><subject>Kidney Transplantation - adverse effects</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Peptide Fragments - metabolism</subject><subject>Retrospective Studies</subject><subject>Risk Factors</subject><subject>Tissue Donors</subject><issn>0934-0874</issn><issn>1432-2277</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkc9qFTEUxoMo9lpd-AIScKOLaZPMZJJxVy5VCwVB6nrInzM1t3OTaZJRZucjdO3j-SRmvNWFIBhIcnLO73yQ8yH0nJITWtZpju6Eso7wB2hDm5pVjAnxEG1IVzcVkaI5Qk9S2hFCmOTkMTpioutY17IN-r6lt1g7b52_xi5hHzJWHpcETFAOn3F06QYPyuQQ8VD2jbMeFqzGMVxHNWQ8hpRwCSCurcrMGUqQnQ52-fHtbg_WqQwWR9iByS54DJNLwcIbrEoyx5CmtfAFsAmfQ8w45dkuT9GjQY0Jnt3fx-jT2_Or7fvq8sO7i-3ZZWXquuUVbbnUVnChlRhseQljZWvkwHVHtAaqLBlaQoVQ0nLDbelq2oaKmkOrqayP0auD7hTD7Qwp93uXDIyj8hDm1FMphKScC_4fKC8-yIbUBX35F7oLc_TlI6sgazmR3Uq9PlCmDCFFGPopur2KS09Jv3rbF2_7X94W9sW94qzLTP-Qv80swOkB-OpGWP6t1F99vDhI_gQjwLBb</recordid><startdate>201703</startdate><enddate>201703</enddate><creator>Moktefi, Anissa</creator><creator>Parisot, Juliette</creator><creator>Desvaux, Dominique</creator><creator>Canoui‐Poitrine, Florence</creator><creator>Brocheriou, Isabelle</creator><creator>Peltier, Julie</creator><creator>Audard, Vincent</creator><creator>Kofman, Tomek</creator><creator>Suberbielle, Caroline</creator><creator>Lang, Philippe</creator><creator>Rondeau, Eric</creator><creator>Grimbert, Philippe</creator><creator>Matignon, Marie</creator><general>Blackwell Publishing Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QO</scope><scope>7T5</scope><scope>8FD</scope><scope>FR3</scope><scope>H94</scope><scope>K9.</scope><scope>P64</scope><scope>7X8</scope></search><sort><creationdate>201703</creationdate><title>C1q binding is not an independent risk factor for kidney allograft loss after an acute antibody‐mediated rejection episode: a retrospective cohort study</title><author>Moktefi, Anissa ; Parisot, Juliette ; Desvaux, Dominique ; Canoui‐Poitrine, Florence ; Brocheriou, Isabelle ; Peltier, Julie ; Audard, Vincent ; Kofman, Tomek ; Suberbielle, Caroline ; Lang, Philippe ; Rondeau, Eric ; Grimbert, Philippe ; Matignon, Marie</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3365-1658bd757ba7fd1657cd86c8f5b90bbe1ad0f60177a8d5c5d3364641735e6b183</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Adult</topic><topic>allograft survival</topic><topic>antibody‐mediated rejection</topic><topic>C1q‐binding DSA</topic><topic>C4d staining</topic><topic>Cohort Studies</topic><topic>Complement C1q - metabolism</topic><topic>Complement C4b - metabolism</topic><topic>Female</topic><topic>Graft Rejection - etiology</topic><topic>Graft Rejection - immunology</topic><topic>Humans</topic><topic>Isoantibodies - metabolism</topic><topic>kidney transplantation</topic><topic>Kidney Transplantation - adverse effects</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Peptide Fragments - metabolism</topic><topic>Retrospective Studies</topic><topic>Risk Factors</topic><topic>Tissue Donors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Moktefi, Anissa</creatorcontrib><creatorcontrib>Parisot, Juliette</creatorcontrib><creatorcontrib>Desvaux, Dominique</creatorcontrib><creatorcontrib>Canoui‐Poitrine, Florence</creatorcontrib><creatorcontrib>Brocheriou, Isabelle</creatorcontrib><creatorcontrib>Peltier, Julie</creatorcontrib><creatorcontrib>Audard, Vincent</creatorcontrib><creatorcontrib>Kofman, Tomek</creatorcontrib><creatorcontrib>Suberbielle, Caroline</creatorcontrib><creatorcontrib>Lang, Philippe</creatorcontrib><creatorcontrib>Rondeau, Eric</creatorcontrib><creatorcontrib>Grimbert, Philippe</creatorcontrib><creatorcontrib>Matignon, Marie</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Biotechnology Research Abstracts</collection><collection>Immunology Abstracts</collection><collection>Technology Research Database</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Transplant international</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Moktefi, Anissa</au><au>Parisot, Juliette</au><au>Desvaux, Dominique</au><au>Canoui‐Poitrine, Florence</au><au>Brocheriou, Isabelle</au><au>Peltier, Julie</au><au>Audard, Vincent</au><au>Kofman, Tomek</au><au>Suberbielle, Caroline</au><au>Lang, Philippe</au><au>Rondeau, Eric</au><au>Grimbert, Philippe</au><au>Matignon, Marie</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>C1q binding is not an independent risk factor for kidney allograft loss after an acute antibody‐mediated rejection episode: a retrospective cohort study</atitle><jtitle>Transplant international</jtitle><addtitle>Transpl Int</addtitle><date>2017-03</date><risdate>2017</risdate><volume>30</volume><issue>3</issue><spage>277</spage><epage>287</epage><pages>277-287</pages><issn>0934-0874</issn><eissn>1432-2277</eissn><abstract>Summary
After kidney transplantation, C4d is an incomplete marker of acute antibody‐mediated rejection (AMR) and C1q‐binding donor‐specific antibodies (DSA) have been associated with allograft survival. However, the impact on allograft survival of C1q+ DSA after clinical AMR has not been studied yet. We analysed retrospectively in clinical AMR C4d staining and C1q‐binding impact on allograft survival. We compared clinical, histological and serological features of C4d− and C4d+ AMR, C1q+ and C1q− DSA AMR and analysed C4d and C1q‐binding impact on allograft survival. Among 500 for‐cause kidney allograft biopsies, 48 fulfilled AMR criteria. C4d+ AMR [N = 18 (37.5%)] have significantly higher number class I DSA (P = 0.02), higher microvascular score (P = 0.02) and more transplant glomerulopathy (P = 0.04). C1q+ AMR [N = 20 (44%)] presented with significantly more class I and class II DSA (P = 0.005 and 0.04) and C4d+ staining (P = 0.01). Graft losses were significantly higher in the C4d+ group (P = 0.04) but similar in C1q groups. C4d+ but not C1q+ binding was an independent risk factor for graft loss [HR = 2.65; (1.11–6.34); P = 0.028]. In our cohort of clinical AMR, C4d+ staining but not C1q+ binding is an independent risk factor for graft loss. Allograft loss and patient survival were similar in C1q+ and C1q− AMR.</abstract><cop>England</cop><pub>Blackwell Publishing Ltd</pub><pmid>27992962</pmid><doi>10.1111/tri.12905</doi><tpages>11</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Transplant international, 2017-03, Vol.30 (3), p.277-287 |
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| subjects | Adult allograft survival antibody‐mediated rejection C1q‐binding DSA C4d staining Cohort Studies Complement C1q - metabolism Complement C4b - metabolism Female Graft Rejection - etiology Graft Rejection - immunology Humans Isoantibodies - metabolism kidney transplantation Kidney Transplantation - adverse effects Male Middle Aged Peptide Fragments - metabolism Retrospective Studies Risk Factors Tissue Donors |
| title | C1q binding is not an independent risk factor for kidney allograft loss after an acute antibody‐mediated rejection episode: a retrospective cohort study |
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