Reconditioning by end‐ischemic hypothermic in‐house machine perfusion: A promising strategy to improve outcome in expanded criteria donors kidney transplantation
This clinical study evaluates end‐ischemic hypothermic machine perfusion (eHMP) in expanded criteria donors (ECD) kidneys. eHMP was initiated upon arrival of the kidney in our center and continued until transplantation. Between 11/2011 and 8/2014 eHMP was performed in 66 ECD kidneys for 369 (98‐912)...
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| Veröffentlicht in: | Clinical transplantation 2017-03, Vol.31 (3), p.np-n/a |
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| creator | Gallinat, Anja Amrillaeva, Vera Hoyer, Dieter P. Kocabayoglu, Peri Benko, Tamas Treckmann, Jürgen W. Meel, Marieke Samuel, Undine Minor, Thomas Paul, Andreas |
| description | This clinical study evaluates end‐ischemic hypothermic machine perfusion (eHMP) in expanded criteria donors (ECD) kidneys. eHMP was initiated upon arrival of the kidney in our center and continued until transplantation. Between 11/2011 and 8/2014 eHMP was performed in 66 ECD kidneys for 369 (98‐912) minutes after 863 (364‐1567) minutes of cold storage (CS). In 49 of 66 cases, the contralateral kidney from the same donor was preserved by static CS only and accepted by another Eurotransplant (ET) center. Five (10.2%) of these kidneys were ultimately judged as “not transplantable” by the accepting center and discarded. After exclusion of early unrelated graft losses, 43 kidney pairs from the same donor were eligible for direct comparison of eHMP vs CS only: primary non‐function and delayed graft function (DGF) were 0% vs 9.3% (P=.04) and 11.6% vs 20.9% (P=.24). There was no statistically significant difference in 1‐year graft survival (eHMP vs CS only: 97.7% vs 88.4%, P=.089). In a multivariate analysis, eHMP was an independent factor for prevention of DGF (OR: 0.28, P=.041). Development of DGF was the strongest risk factor for 1‐year graft failure (Renal resistance: 38.2, P |
| doi_str_mv | 10.1111/ctr.12904 |
| format | Article |
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Between 11/2011 and 8/2014 eHMP was performed in 66 ECD kidneys for 369 (98‐912) minutes after 863 (364‐1567) minutes of cold storage (CS). In 49 of 66 cases, the contralateral kidney from the same donor was preserved by static CS only and accepted by another Eurotransplant (ET) center. Five (10.2%) of these kidneys were ultimately judged as “not transplantable” by the accepting center and discarded. After exclusion of early unrelated graft losses, 43 kidney pairs from the same donor were eligible for direct comparison of eHMP vs CS only: primary non‐function and delayed graft function (DGF) were 0% vs 9.3% (P=.04) and 11.6% vs 20.9% (P=.24). There was no statistically significant difference in 1‐year graft survival (eHMP vs CS only: 97.7% vs 88.4%, P=.089). In a multivariate analysis, eHMP was an independent factor for prevention of DGF (OR: 0.28, P=.041). Development of DGF was the strongest risk factor for 1‐year graft failure (Renal resistance: 38.2, P<.001). In summary, eHMP is a promising reconditioning technique to improve the quality and acceptance rate of suboptimal grafts.</description><identifier>ISSN: 0902-0063</identifier><identifier>EISSN: 1399-0012</identifier><identifier>DOI: 10.1111/ctr.12904</identifier><identifier>PMID: 28035688</identifier><language>eng</language><publisher>Denmark</publisher><subject>Adult ; Aged ; Aged, 80 and over ; Cryopreservation ; delayed graft function ; Female ; Follow-Up Studies ; Glomerular Filtration Rate ; Graft Rejection - epidemiology ; Graft Rejection - prevention & control ; Graft Survival ; Humans ; Hypothermia, Induced ; Kidney Failure, Chronic - surgery ; Kidney Function Tests ; Kidney Transplantation ; machine perfusion ; Male ; Middle Aged ; Organ Preservation - methods ; Perfusion - instrumentation ; primary kidney function ; Prognosis ; reconditioning ; Risk Factors ; Tissue and Organ Procurement - methods ; Tissue Donors</subject><ispartof>Clinical transplantation, 2017-03, Vol.31 (3), p.np-n/a</ispartof><rights>2017 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd</rights><rights>2017 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3584-2f38cfeb08fed2279220de2fd884e99702420c44b0f5162181ace2a0790b0a323</citedby><cites>FETCH-LOGICAL-c3584-2f38cfeb08fed2279220de2fd884e99702420c44b0f5162181ace2a0790b0a323</cites><orcidid>0000-0002-0479-5897</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1111%2Fctr.12904$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1111%2Fctr.12904$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>314,776,780,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28035688$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Gallinat, Anja</creatorcontrib><creatorcontrib>Amrillaeva, Vera</creatorcontrib><creatorcontrib>Hoyer, Dieter P.</creatorcontrib><creatorcontrib>Kocabayoglu, Peri</creatorcontrib><creatorcontrib>Benko, Tamas</creatorcontrib><creatorcontrib>Treckmann, Jürgen W.</creatorcontrib><creatorcontrib>Meel, Marieke</creatorcontrib><creatorcontrib>Samuel, Undine</creatorcontrib><creatorcontrib>Minor, Thomas</creatorcontrib><creatorcontrib>Paul, Andreas</creatorcontrib><title>Reconditioning by end‐ischemic hypothermic in‐house machine perfusion: A promising strategy to improve outcome in expanded criteria donors kidney transplantation</title><title>Clinical transplantation</title><addtitle>Clin Transplant</addtitle><description>This clinical study evaluates end‐ischemic hypothermic machine perfusion (eHMP) in expanded criteria donors (ECD) kidneys. eHMP was initiated upon arrival of the kidney in our center and continued until transplantation. Between 11/2011 and 8/2014 eHMP was performed in 66 ECD kidneys for 369 (98‐912) minutes after 863 (364‐1567) minutes of cold storage (CS). In 49 of 66 cases, the contralateral kidney from the same donor was preserved by static CS only and accepted by another Eurotransplant (ET) center. Five (10.2%) of these kidneys were ultimately judged as “not transplantable” by the accepting center and discarded. After exclusion of early unrelated graft losses, 43 kidney pairs from the same donor were eligible for direct comparison of eHMP vs CS only: primary non‐function and delayed graft function (DGF) were 0% vs 9.3% (P=.04) and 11.6% vs 20.9% (P=.24). There was no statistically significant difference in 1‐year graft survival (eHMP vs CS only: 97.7% vs 88.4%, P=.089). In a multivariate analysis, eHMP was an independent factor for prevention of DGF (OR: 0.28, P=.041). Development of DGF was the strongest risk factor for 1‐year graft failure (Renal resistance: 38.2, P<.001). In summary, eHMP is a promising reconditioning technique to improve the quality and acceptance rate of suboptimal grafts.</description><subject>Adult</subject><subject>Aged</subject><subject>Aged, 80 and over</subject><subject>Cryopreservation</subject><subject>delayed graft function</subject><subject>Female</subject><subject>Follow-Up Studies</subject><subject>Glomerular Filtration Rate</subject><subject>Graft Rejection - epidemiology</subject><subject>Graft Rejection - prevention & control</subject><subject>Graft Survival</subject><subject>Humans</subject><subject>Hypothermia, Induced</subject><subject>Kidney Failure, Chronic - surgery</subject><subject>Kidney Function Tests</subject><subject>Kidney Transplantation</subject><subject>machine perfusion</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Organ Preservation - methods</subject><subject>Perfusion - instrumentation</subject><subject>primary kidney function</subject><subject>Prognosis</subject><subject>reconditioning</subject><subject>Risk Factors</subject><subject>Tissue and Organ Procurement - methods</subject><subject>Tissue Donors</subject><issn>0902-0063</issn><issn>1399-0012</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqNkc9u1DAQxi0EokvhwAsgH-Gw7dhxEptbteKfVAmpKufIsSeNYWMH2ynkxiPwErwYT4KXLdyQ8MWjmd98-kYfIU8ZnLHyzk2OZ4wrEPfIhlVKbQEYv082oICXuqlOyKOUPpZuw5r6ITnhEqq6kXJDflyhCd667IJ3_ob2K0Vvf3777pIZcXKGjusc8ojxUDtfJmNYEtJJm9F5pDPGYUll-yW9oHMMk0sHnZSjzniz0hyom0r_FmlYsgkTFhWKX2ftLVpqossYnaY2-BAT_eSsx7IVtU_zXvusD84ekweD3id8cvefkg-vX13v3m4v3795t7u43JqqlmLLh0qaAXuQA1rOW8U5WOSDlVKgUi1wwcEI0cNQs4YzybRBrqFV0IOueHVKnh91i-HPC6bclXMM7osRLFd3TLatZDWH-j_QWjRMKNEW9MURNTGkFHHo5ugmHdeOQXcIsCsBdr8DLOyzO9mln9D-Jf8kVoDzI_DF7XH9t1K3u746Sv4CA66qxg</recordid><startdate>201703</startdate><enddate>201703</enddate><creator>Gallinat, Anja</creator><creator>Amrillaeva, Vera</creator><creator>Hoyer, Dieter P.</creator><creator>Kocabayoglu, Peri</creator><creator>Benko, Tamas</creator><creator>Treckmann, Jürgen W.</creator><creator>Meel, Marieke</creator><creator>Samuel, Undine</creator><creator>Minor, Thomas</creator><creator>Paul, Andreas</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7T5</scope><scope>H94</scope><orcidid>https://orcid.org/0000-0002-0479-5897</orcidid></search><sort><creationdate>201703</creationdate><title>Reconditioning by end‐ischemic hypothermic in‐house machine perfusion: A promising strategy to improve outcome in expanded criteria donors kidney transplantation</title><author>Gallinat, Anja ; Amrillaeva, Vera ; Hoyer, Dieter P. ; Kocabayoglu, Peri ; Benko, Tamas ; Treckmann, Jürgen W. ; Meel, Marieke ; Samuel, Undine ; Minor, Thomas ; Paul, Andreas</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3584-2f38cfeb08fed2279220de2fd884e99702420c44b0f5162181ace2a0790b0a323</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Aged, 80 and over</topic><topic>Cryopreservation</topic><topic>delayed graft function</topic><topic>Female</topic><topic>Follow-Up Studies</topic><topic>Glomerular Filtration Rate</topic><topic>Graft Rejection - epidemiology</topic><topic>Graft Rejection - prevention & control</topic><topic>Graft Survival</topic><topic>Humans</topic><topic>Hypothermia, Induced</topic><topic>Kidney Failure, Chronic - surgery</topic><topic>Kidney Function Tests</topic><topic>Kidney Transplantation</topic><topic>machine perfusion</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Organ Preservation - methods</topic><topic>Perfusion - instrumentation</topic><topic>primary kidney function</topic><topic>Prognosis</topic><topic>reconditioning</topic><topic>Risk Factors</topic><topic>Tissue and Organ Procurement - methods</topic><topic>Tissue Donors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Gallinat, Anja</creatorcontrib><creatorcontrib>Amrillaeva, Vera</creatorcontrib><creatorcontrib>Hoyer, Dieter P.</creatorcontrib><creatorcontrib>Kocabayoglu, Peri</creatorcontrib><creatorcontrib>Benko, Tamas</creatorcontrib><creatorcontrib>Treckmann, Jürgen W.</creatorcontrib><creatorcontrib>Meel, Marieke</creatorcontrib><creatorcontrib>Samuel, Undine</creatorcontrib><creatorcontrib>Minor, Thomas</creatorcontrib><creatorcontrib>Paul, Andreas</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><jtitle>Clinical transplantation</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Gallinat, Anja</au><au>Amrillaeva, Vera</au><au>Hoyer, Dieter P.</au><au>Kocabayoglu, Peri</au><au>Benko, Tamas</au><au>Treckmann, Jürgen W.</au><au>Meel, Marieke</au><au>Samuel, Undine</au><au>Minor, Thomas</au><au>Paul, Andreas</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Reconditioning by end‐ischemic hypothermic in‐house machine perfusion: A promising strategy to improve outcome in expanded criteria donors kidney transplantation</atitle><jtitle>Clinical transplantation</jtitle><addtitle>Clin Transplant</addtitle><date>2017-03</date><risdate>2017</risdate><volume>31</volume><issue>3</issue><spage>np</spage><epage>n/a</epage><pages>np-n/a</pages><issn>0902-0063</issn><eissn>1399-0012</eissn><abstract>This clinical study evaluates end‐ischemic hypothermic machine perfusion (eHMP) in expanded criteria donors (ECD) kidneys. eHMP was initiated upon arrival of the kidney in our center and continued until transplantation. Between 11/2011 and 8/2014 eHMP was performed in 66 ECD kidneys for 369 (98‐912) minutes after 863 (364‐1567) minutes of cold storage (CS). In 49 of 66 cases, the contralateral kidney from the same donor was preserved by static CS only and accepted by another Eurotransplant (ET) center. Five (10.2%) of these kidneys were ultimately judged as “not transplantable” by the accepting center and discarded. After exclusion of early unrelated graft losses, 43 kidney pairs from the same donor were eligible for direct comparison of eHMP vs CS only: primary non‐function and delayed graft function (DGF) were 0% vs 9.3% (P=.04) and 11.6% vs 20.9% (P=.24). There was no statistically significant difference in 1‐year graft survival (eHMP vs CS only: 97.7% vs 88.4%, P=.089). In a multivariate analysis, eHMP was an independent factor for prevention of DGF (OR: 0.28, P=.041). Development of DGF was the strongest risk factor for 1‐year graft failure (Renal resistance: 38.2, P<.001). In summary, eHMP is a promising reconditioning technique to improve the quality and acceptance rate of suboptimal grafts.</abstract><cop>Denmark</cop><pmid>28035688</pmid><doi>10.1111/ctr.12904</doi><tpages>8</tpages><orcidid>https://orcid.org/0000-0002-0479-5897</orcidid></addata></record> |
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| ispartof | Clinical transplantation, 2017-03, Vol.31 (3), p.np-n/a |
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| subjects | Adult Aged Aged, 80 and over Cryopreservation delayed graft function Female Follow-Up Studies Glomerular Filtration Rate Graft Rejection - epidemiology Graft Rejection - prevention & control Graft Survival Humans Hypothermia, Induced Kidney Failure, Chronic - surgery Kidney Function Tests Kidney Transplantation machine perfusion Male Middle Aged Organ Preservation - methods Perfusion - instrumentation primary kidney function Prognosis reconditioning Risk Factors Tissue and Organ Procurement - methods Tissue Donors |
| title | Reconditioning by end‐ischemic hypothermic in‐house machine perfusion: A promising strategy to improve outcome in expanded criteria donors kidney transplantation |
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