Correlating blood and urinary concentrations of clobazam doses in Japanese children and adolescents with intractable epilepsy

Clobazam (CLB) is an antiepileptic drug that is metabolized to the major metabolite N‐desmethylclobazam (N‐CLB). Our aim was to evaluate the utility of corrected urinary concentrations of CLB and N‐CLB in Japanese children and adolescents with epilepsy. Blood and urinary concentrations of CLB and N‐...

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Veröffentlicht in:Biomedical chromatography 2017-04, Vol.31 (4), p.np-n/a
Hauptverfasser: Iwasaki, Toshiyuki, Nonoda, Yutaka, Ishida, Tomoya, Toki, Taira, Ishii, Masahiro
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Sprache:eng
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Zusammenfassung:Clobazam (CLB) is an antiepileptic drug that is metabolized to the major metabolite N‐desmethylclobazam (N‐CLB). Our aim was to evaluate the utility of corrected urinary concentrations of CLB and N‐CLB in Japanese children and adolescents with epilepsy. Blood and urinary concentrations of CLB and N‐CLB were evaluated in 42 patients. The urinary and peak blood concentrations were measured 2–3 h after the last dose. The ratio of the blood and urinary creatinine concentrations was used to calculate the corrected urinary concentrations. A moderate correlation was found between the CLB dose and the CLB serum concentration, but this correlation was not found for N‐CLB. Patients were dichotomized based on two regression lines, which were detected by statistical analyses with a cumulative distribution function: the lower ratio group (CLB/N‐CLB 
ISSN:0269-3879
1099-0801
DOI:10.1002/bmc.3848