Toxic effects of 4‐methylthio‐3‐butenyl isothiocyanate (Raphasatin) in the rat urinary bladder without genotoxicity

We recently reported that 4‐methylthio‐3‐butenyl isothiocyanate (MTBITC) exerts chemopreventive effects on the rat esophageal carcinogenesis model at a low dose of 80 ppm in a diet. In contrast, some isothiocyanates (ITCs) have been reported to cause toxic effects, promotion activity, and/or carcino...

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Veröffentlicht in:	Journal of applied toxicology 2017-04, Vol.37 (4), p.485-494
Hauptverfasser:	Suzuki, Isamu, Cho, Young‐Man, Hirata, Tadashi, Toyoda, Takeshi, Akagi, Jun‐ichi, Nakamura, Yasushi, Sasaki, Azusa, Nakamura, Takako, Okamoto, Shigehisa, Shirota, Koji, Suetome, Noboru, Nishikawa, Akiyoshi, Ogawa, Kumiko
Format:	Artikel
Sprache:	eng
Schlagworte:	4‐methylthio‐3‐butenyl isothiocyanate Animals Anticarcinogenic Agents - toxicity Bladder Bone Marrow Cells - drug effects DNA Damage Eating - drug effects Esophageal cancer genotoxicity Histopathology Isothiocyanates - toxicity Male Mutagenicity Tests Mutagens - toxicity Organ Size - drug effects phenethyl isothiocyanate Raphasatin Rats Rats, Inbred F344 Rodents Toxicity Urinary Bladder - drug effects Urinary Bladder - pathology Urinary Bladder Diseases - chemically induced Urinary Bladder Diseases - genetics Urinary Bladder Diseases - pathology urinary bladder toxicity
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