Droperidol in the Emergency Department: is it safe?
Droperidol is an antipsychotic and antiemetic drug that has been used extensively by Emergency Physicians, Psychiatrists, and Anesthesiologists worldwide since 1967. It also has been used effectively for other diverse conditions, such as treatment of headache and vertigo. As of January 2001, Droperi...
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| Veröffentlicht in: | The Journal of emergency medicine 2003-05, Vol.24 (4), p.441-447 |
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| container_end_page | 447 |
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| container_title | The Journal of emergency medicine |
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| creator | Richards, John R Schneir, Aaron B |
| description | Droperidol is an antipsychotic and antiemetic drug that has been used extensively by Emergency Physicians, Psychiatrists, and Anesthesiologists worldwide since 1967. It also has been used effectively for other diverse conditions, such as treatment of headache and vertigo. As of January 2001, Droperidol was no longer available in Europe after its founder, Janssen-Cilag Pharmaceuticals, discontinued its distribution. In December 2001, the United States Food and Drug Administration (FDA) placed a black box warning on the use of Droperidol in response to an association between Droperidol and fatal cardiac dysrhythmias, such as torsade de pointes, resulting from prolongation of the QT interval. In this review we closely examine the pharmacology, indications, use, and complications associated with Droperidol, and speculate on its future use in the Emergency Department. |
| doi_str_mv | 10.1016/S0736-4679(03)00044-1 |
| format | Article |
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Drug treatments</subject><subject>Psycholeptics: tranquillizer, neuroleptic</subject><subject>Psychology. Psychoanalysis. Psychiatry</subject><subject>Psychopharmacology</subject><subject>Risk Factors</subject><subject>Safety</subject><subject>Torsades de Pointes - chemically induced</subject><subject>Toxicity: cardiovascular system</subject><subject>United States</subject><subject>United States Food and Drug Administration</subject><issn>0736-4679</issn><issn>2352-5029</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2003</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkMtOwzAQRS0EoqXwCaBsQLAIjONXwqZCbXlIlVgAa8txJmCUR7FTpP496UOwZDOzOXfm6hBySuGaApU3L6CYjLlU2SWwKwDgPKZ7ZJgwkcQCkmyfDH-RATkK4ROAKkjpIRnQRHEBPBsSNvXtAr0r2ipyTdR9YDSr0b9jY1fRFBfGdzU23W3kQuS6KJgSx8fkoDRVwJPdHpG3-9nr5DGePz88Te7mseVJ0sXIDReW0b4uL2RqkRooclkKSFHlCgWjIsk55FlqUNqSJ4JCjoxzK4t-sBG52N5d-PZriaHTtQsWq8o02C6DpqlSIpXQg2ILWt-G4LHUC-9q41eagl7b0htbeq1CA9MbW5r2ubPdg2VeY_GX2unpgfMdYII1VelNY13447hKMwWy58ZbDnsd3w69Dtb1CrFwHm2ni9b9U-UHWAWEdg</recordid><startdate>20030501</startdate><enddate>20030501</enddate><creator>Richards, John R</creator><creator>Schneir, Aaron B</creator><general>Elsevier Inc</general><general>Elsevier</general><scope>IQODW</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T2</scope><scope>7U1</scope><scope>7U2</scope><scope>C1K</scope></search><sort><creationdate>20030501</creationdate><title>Droperidol in the Emergency Department: is it safe?</title><author>Richards, John R ; Schneir, Aaron B</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c422t-e4a45c311014d68ce1a0db6f508e7b7e53152b40b98ae6cf42510be344c6d44c3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2003</creationdate><topic>Antiemetics - adverse effects</topic><topic>Antiemetics - chemistry</topic><topic>Antiemetics - therapeutic use</topic><topic>antipsychotic</topic><topic>Antipsychotic Agents - adverse effects</topic><topic>Antipsychotic Agents - chemistry</topic><topic>Antipsychotic Agents - therapeutic use</topic><topic>Biological and medical sciences</topic><topic>Death, Sudden, Cardiac - etiology</topic><topic>Droperidol</topic><topic>Droperidol - adverse effects</topic><topic>Droperidol - chemistry</topic><topic>Droperidol - therapeutic use</topic><topic>Drug Labeling</topic><topic>Drug toxicity and drugs side effects treatment</topic><topic>Emergency Department</topic><topic>Emergency Treatment - adverse effects</topic><topic>Emergency Treatment - methods</topic><topic>FDA warning</topic><topic>Humans</topic><topic>Inapsine</topic><topic>Long QT Syndrome - chemically induced</topic><topic>Medical sciences</topic><topic>Neuropharmacology</topic><topic>Patient Selection</topic><topic>Pharmacology. 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| ispartof | The Journal of emergency medicine, 2003-05, Vol.24 (4), p.441-447 |
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| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals |
| subjects | Antiemetics - adverse effects Antiemetics - chemistry Antiemetics - therapeutic use antipsychotic Antipsychotic Agents - adverse effects Antipsychotic Agents - chemistry Antipsychotic Agents - therapeutic use Biological and medical sciences Death, Sudden, Cardiac - etiology Droperidol Droperidol - adverse effects Droperidol - chemistry Droperidol - therapeutic use Drug Labeling Drug toxicity and drugs side effects treatment Emergency Department Emergency Treatment - adverse effects Emergency Treatment - methods FDA warning Humans Inapsine Long QT Syndrome - chemically induced Medical sciences Neuropharmacology Patient Selection Pharmacology. Drug treatments Psycholeptics: tranquillizer, neuroleptic Psychology. Psychoanalysis. Psychiatry Psychopharmacology Risk Factors Safety Torsades de Pointes - chemically induced Toxicity: cardiovascular system United States United States Food and Drug Administration |
| title | Droperidol in the Emergency Department: is it safe? |
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