Correlation of body temperature with protection against staphylococcal enterotoxin B exposure and use in determining vaccine dose-schedule
The immunoprotective potential of a recombinant vaccine against the incapacitating effect of aerosolized staphylococcal enterotoxin B (SEB) in nonhuman primates is reported. SEB belongs to a family of structurally related superantigens responsible for serious, life threatening pathologies. Injecting...
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| Veröffentlicht in: | Vaccine 2003-06, Vol.21 (21), p.2791-2796 |
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| creator | Boles, James W. M. Pitt, M.Louise LeClaire, Ross D. Gibbs, Paul H. Ulrich, Robert G. Bavari, Sina |
| description | The immunoprotective potential of a recombinant vaccine against the incapacitating effect of aerosolized staphylococcal enterotoxin B (SEB) in nonhuman primates is reported. SEB belongs to a family of structurally related superantigens responsible for serious, life threatening pathologies. Injecting the recombinant SEB vaccine did not induce temperature elevation in rhesus monkeys, a classical symptom of toxic-shock syndrome. No temperature elevation was noted following injection with control tetanus toxoid. In addition to 100% survival, we observed a clear correlation between vaccine dose and mitigation of temperature elevation after a lethal SEB aerosol challenge. We conclude that the recombinant SEB vaccine is non-pyrogenic and that monitoring changes in body temperature is an important biomarker of toxic shock in a primate animal model. |
| doi_str_mv | 10.1016/S0264-410X(03)00222-6 |
| format | Article |
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Pitt, M.Louise ; LeClaire, Ross D. ; Gibbs, Paul H. ; Ulrich, Robert G. ; Bavari, Sina</creator><creatorcontrib>Boles, James W. ; M. Pitt, M.Louise ; LeClaire, Ross D. ; Gibbs, Paul H. ; Ulrich, Robert G. ; Bavari, Sina</creatorcontrib><description>The immunoprotective potential of a recombinant vaccine against the incapacitating effect of aerosolized staphylococcal enterotoxin B (SEB) in nonhuman primates is reported. SEB belongs to a family of structurally related superantigens responsible for serious, life threatening pathologies. Injecting the recombinant SEB vaccine did not induce temperature elevation in rhesus monkeys, a classical symptom of toxic-shock syndrome. No temperature elevation was noted following injection with control tetanus toxoid. In addition to 100% survival, we observed a clear correlation between vaccine dose and mitigation of temperature elevation after a lethal SEB aerosol challenge. We conclude that the recombinant SEB vaccine is non-pyrogenic and that monitoring changes in body temperature is an important biomarker of toxic shock in a primate animal model.</description><identifier>ISSN: 0264-410X</identifier><identifier>EISSN: 1873-2518</identifier><identifier>DOI: 10.1016/S0264-410X(03)00222-6</identifier><identifier>PMID: 12798619</identifier><identifier>CODEN: VACCDE</identifier><language>eng</language><publisher>Oxford: Elsevier Ltd</publisher><subject>Aerosol ; Animal models ; Animals ; Bacterial superantigens ; Bacteriology ; Binding sites ; Biological and medical sciences ; Biomarkers ; Body temperature ; Body Temperature - immunology ; Cytokines ; Disease Models, Animal ; Dose-Response Relationship, Drug ; Enterotoxins - immunology ; Fever - chemically induced ; Fundamental and applied biological sciences. Psychology ; Humans ; Immunization Schedule ; Immunization, Secondary ; Laboratory animals ; Macaca mulatta ; Microbiology ; Monkeys & apes ; Mutation ; Software ; Staphylococcal Vaccines - administration & dosage ; Staphylococcal Vaccines - adverse effects ; Staphylococcal Vaccines - immunology ; Staphylococcus aureus - immunology ; Statistical methods ; Superantigens - immunology ; Telemetry ; Time Factors ; Vaccine ; Vaccines ; Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies ; Vaccines, Synthetic - administration & dosage ; Vaccines, Synthetic - adverse effects ; Vaccines, Synthetic - immunology ; Variance analysis</subject><ispartof>Vaccine, 2003-06, Vol.21 (21), p.2791-2796</ispartof><rights>2003</rights><rights>2003 INIST-CNRS</rights><rights>Copyright Elsevier Limited Jun 20, 2003</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c450t-96637066f470067dabd17707b58e3dc03c8758a7aa9b4f116800787148f88a003</citedby><cites>FETCH-LOGICAL-c450t-96637066f470067dabd17707b58e3dc03c8758a7aa9b4f116800787148f88a003</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.proquest.com/docview/1496649031?pq-origsite=primo$$EHTML$$P50$$Gproquest$$H</linktohtml><link.rule.ids>314,776,780,3536,27903,27904,64361,64363,64365,65309,72215</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=14865957$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/12798619$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Boles, James W.</creatorcontrib><creatorcontrib>M. Pitt, M.Louise</creatorcontrib><creatorcontrib>LeClaire, Ross D.</creatorcontrib><creatorcontrib>Gibbs, Paul H.</creatorcontrib><creatorcontrib>Ulrich, Robert G.</creatorcontrib><creatorcontrib>Bavari, Sina</creatorcontrib><title>Correlation of body temperature with protection against staphylococcal enterotoxin B exposure and use in determining vaccine dose-schedule</title><title>Vaccine</title><addtitle>Vaccine</addtitle><description>The immunoprotective potential of a recombinant vaccine against the incapacitating effect of aerosolized staphylococcal enterotoxin B (SEB) in nonhuman primates is reported. SEB belongs to a family of structurally related superantigens responsible for serious, life threatening pathologies. Injecting the recombinant SEB vaccine did not induce temperature elevation in rhesus monkeys, a classical symptom of toxic-shock syndrome. No temperature elevation was noted following injection with control tetanus toxoid. In addition to 100% survival, we observed a clear correlation between vaccine dose and mitigation of temperature elevation after a lethal SEB aerosol challenge. We conclude that the recombinant SEB vaccine is non-pyrogenic and that monitoring changes in body temperature is an important biomarker of toxic shock in a primate animal model.</description><subject>Aerosol</subject><subject>Animal models</subject><subject>Animals</subject><subject>Bacterial superantigens</subject><subject>Bacteriology</subject><subject>Binding sites</subject><subject>Biological and medical sciences</subject><subject>Biomarkers</subject><subject>Body temperature</subject><subject>Body Temperature - immunology</subject><subject>Cytokines</subject><subject>Disease Models, Animal</subject><subject>Dose-Response Relationship, Drug</subject><subject>Enterotoxins - immunology</subject><subject>Fever - chemically induced</subject><subject>Fundamental and applied biological sciences. 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Pitt, M.Louise</au><au>LeClaire, Ross D.</au><au>Gibbs, Paul H.</au><au>Ulrich, Robert G.</au><au>Bavari, Sina</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Correlation of body temperature with protection against staphylococcal enterotoxin B exposure and use in determining vaccine dose-schedule</atitle><jtitle>Vaccine</jtitle><addtitle>Vaccine</addtitle><date>2003-06-20</date><risdate>2003</risdate><volume>21</volume><issue>21</issue><spage>2791</spage><epage>2796</epage><pages>2791-2796</pages><issn>0264-410X</issn><eissn>1873-2518</eissn><coden>VACCDE</coden><abstract>The immunoprotective potential of a recombinant vaccine against the incapacitating effect of aerosolized staphylococcal enterotoxin B (SEB) in nonhuman primates is reported. SEB belongs to a family of structurally related superantigens responsible for serious, life threatening pathologies. Injecting the recombinant SEB vaccine did not induce temperature elevation in rhesus monkeys, a classical symptom of toxic-shock syndrome. No temperature elevation was noted following injection with control tetanus toxoid. In addition to 100% survival, we observed a clear correlation between vaccine dose and mitigation of temperature elevation after a lethal SEB aerosol challenge. We conclude that the recombinant SEB vaccine is non-pyrogenic and that monitoring changes in body temperature is an important biomarker of toxic shock in a primate animal model.</abstract><cop>Oxford</cop><pub>Elsevier Ltd</pub><pmid>12798619</pmid><doi>10.1016/S0264-410X(03)00222-6</doi><tpages>6</tpages></addata></record> |
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| ispartof | Vaccine, 2003-06, Vol.21 (21), p.2791-2796 |
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| subjects | Aerosol Animal models Animals Bacterial superantigens Bacteriology Binding sites Biological and medical sciences Biomarkers Body temperature Body Temperature - immunology Cytokines Disease Models, Animal Dose-Response Relationship, Drug Enterotoxins - immunology Fever - chemically induced Fundamental and applied biological sciences. Psychology Humans Immunization Schedule Immunization, Secondary Laboratory animals Macaca mulatta Microbiology Monkeys & apes Mutation Software Staphylococcal Vaccines - administration & dosage Staphylococcal Vaccines - adverse effects Staphylococcal Vaccines - immunology Staphylococcus aureus - immunology Statistical methods Superantigens - immunology Telemetry Time Factors Vaccine Vaccines Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies Vaccines, Synthetic - administration & dosage Vaccines, Synthetic - adverse effects Vaccines, Synthetic - immunology Variance analysis |
| title | Correlation of body temperature with protection against staphylococcal enterotoxin B exposure and use in determining vaccine dose-schedule |
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