Acute and subacute oral toxicity assessment of the oil extracted from Attalea phalerata Mart ex Spreng. pulp fruit in rats

Attalea phalerata Mart. ex Spreng., popularly known as “bacuri”, is a native plant from the brazilian Cerrado and used in folk medicine as a pulmonary decongestant, an anti-inflammatory for joints and antipyretic. There is an expectation about the use in chronic disease of the Attalea phalerata oil...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Food research international 2017-01, Vol.91, p.11-17
Hauptverfasser: Freitas de Lima, Fernando, Traesel, Giseli Karenina, Menegati, Sara Emilia Lima Tolouei, Santos, Ariany Carvalho dos, Souza, Roosevelt Isaias Carvalho, de Oliveira, Vinícius Soares, Sanjinez-Argandoña, Eliana Janet, Cardoso, Claudia Andrea Lima, Oesterreich, Silvia Aparecida, Vieira, Maria do Carmo
Format: Artikel
Sprache:eng
Schlagworte:
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page 17
container_issue
container_start_page 11
container_title Food research international
container_volume 91
creator Freitas de Lima, Fernando
Traesel, Giseli Karenina
Menegati, Sara Emilia Lima Tolouei
Santos, Ariany Carvalho dos
Souza, Roosevelt Isaias Carvalho
de Oliveira, Vinícius Soares
Sanjinez-Argandoña, Eliana Janet
Cardoso, Claudia Andrea Lima
Oesterreich, Silvia Aparecida
Vieira, Maria do Carmo
description Attalea phalerata Mart. ex Spreng., popularly known as “bacuri”, is a native plant from the brazilian Cerrado and used in folk medicine as a pulmonary decongestant, an anti-inflammatory for joints and antipyretic. There is an expectation about the use in chronic disease of the Attalea phalerata oil since its composition is high in carotenoids and beneficial fatty acids. The aim of the study was to evaluate the toxicological profile of the oil extracted from Attalea phalerata Mart. ex Spreng. pulp (APO). Acute and subacute toxicity studies were performed in male and female Wistar rats according to the OECD - Guidelines 425 and 407. For the acute toxicity, one single dose of the APO (2000mg/kg) was administered by gavage to five female rats. In the subacute toxicity, four different doses (125, 250, 500 and 1000mg/kg) of the APO were administered to male and female rats for 28 consecutive days. No deaths or behavioral changes were observed during both experiments as well as no changes in organ weights, hematological, histopathological parameters. The biochemical parameters showed changes in phosphatase alkaline and albumin levels, however these values are within the normal range for the species. A significant reduction in cholesterol and triglycerides was also observed in some of the animals treated with the APO. Therefore, the LD50 is higher than 2000mg/kg and the APO oil can be considered safe at the doses tested in rats. However, further assessments are required in order to proceed to clinical studies in humans. [Display omitted] •Oral acute and sub-acute toxicities of Attalea phalerata Mart. ex Spreng oil were studied.•The fruit has a high content of carotenoids and healthy fatty acids.•The organs of the animals had a normal size and no macroscopic change.•Toxic changes were not observed in biochemical and hematological parameters.•The pulp oil does not affect the histological parameters.
doi_str_mv 10.1016/j.foodres.2016.11.019
format Article
fullrecord <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1877528455</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><els_id>S0963996916305592</els_id><sourcerecordid>1877528455</sourcerecordid><originalsourceid>FETCH-LOGICAL-c431t-5974667b6b63944cd2570a99ddca805e08ef163d9d8a9e9eecf0f963cd3a54983</originalsourceid><addsrcrecordid>eNqFkMFO3DAQhq0KVBbaR2jlI5ekdhI78alaIVqQQByAszVrT4pXSZzaDmL79JjutldOo9F8M6P_I-QLZyVnXH7blr33NmAsq9yWnJeMqw9kxbu2LlreiCOyYkrWhVJSnZDTGLeMMSla9ZGcVF2lWM2bFfmzNktCCpOlcdnA38YHGGjyL864tKMQI8Y44pSo72l6ynM3UHxJAUxCS_vgR7pOCQYEOj_lEiABvYWQMkXv54DTr5LOyzBndnGJuolmJH4ixz0MET8f6hl5_HH5cHFV3Nz9vL5Y3xSmqXkqhGobKduN3MhaNY2xlWgZKGWtgY4JZB32XNZW2Q4UKkTTsz4HN7YG0aiuPiPn-7tz8L8XjEmPLhocBpjQL1FnY62oukaIjIo9aoKPMWCv5-BGCDvNmX7Trrf6oF2_adec66w97309vFg2I9r_W_88Z-D7HsAc9Nlh0NE4nAxaF9Akbb1758UrZieYKg</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1877528455</pqid></control><display><type>article</type><title>Acute and subacute oral toxicity assessment of the oil extracted from Attalea phalerata Mart ex Spreng. pulp fruit in rats</title><source>MEDLINE</source><source>Elsevier ScienceDirect Journals</source><creator>Freitas de Lima, Fernando ; Traesel, Giseli Karenina ; Menegati, Sara Emilia Lima Tolouei ; Santos, Ariany Carvalho dos ; Souza, Roosevelt Isaias Carvalho ; de Oliveira, Vinícius Soares ; Sanjinez-Argandoña, Eliana Janet ; Cardoso, Claudia Andrea Lima ; Oesterreich, Silvia Aparecida ; Vieira, Maria do Carmo</creator><creatorcontrib>Freitas de Lima, Fernando ; Traesel, Giseli Karenina ; Menegati, Sara Emilia Lima Tolouei ; Santos, Ariany Carvalho dos ; Souza, Roosevelt Isaias Carvalho ; de Oliveira, Vinícius Soares ; Sanjinez-Argandoña, Eliana Janet ; Cardoso, Claudia Andrea Lima ; Oesterreich, Silvia Aparecida ; Vieira, Maria do Carmo</creatorcontrib><description>Attalea phalerata Mart. ex Spreng., popularly known as “bacuri”, is a native plant from the brazilian Cerrado and used in folk medicine as a pulmonary decongestant, an anti-inflammatory for joints and antipyretic. There is an expectation about the use in chronic disease of the Attalea phalerata oil since its composition is high in carotenoids and beneficial fatty acids. The aim of the study was to evaluate the toxicological profile of the oil extracted from Attalea phalerata Mart. ex Spreng. pulp (APO). Acute and subacute toxicity studies were performed in male and female Wistar rats according to the OECD - Guidelines 425 and 407. For the acute toxicity, one single dose of the APO (2000mg/kg) was administered by gavage to five female rats. In the subacute toxicity, four different doses (125, 250, 500 and 1000mg/kg) of the APO were administered to male and female rats for 28 consecutive days. No deaths or behavioral changes were observed during both experiments as well as no changes in organ weights, hematological, histopathological parameters. The biochemical parameters showed changes in phosphatase alkaline and albumin levels, however these values are within the normal range for the species. A significant reduction in cholesterol and triglycerides was also observed in some of the animals treated with the APO. Therefore, the LD50 is higher than 2000mg/kg and the APO oil can be considered safe at the doses tested in rats. However, further assessments are required in order to proceed to clinical studies in humans. [Display omitted] •Oral acute and sub-acute toxicities of Attalea phalerata Mart. ex Spreng oil were studied.•The fruit has a high content of carotenoids and healthy fatty acids.•The organs of the animals had a normal size and no macroscopic change.•Toxic changes were not observed in biochemical and hematological parameters.•The pulp oil does not affect the histological parameters.</description><identifier>ISSN: 0963-9969</identifier><identifier>EISSN: 1873-7145</identifier><identifier>DOI: 10.1016/j.foodres.2016.11.019</identifier><identifier>PMID: 28290314</identifier><language>eng</language><publisher>Canada: Elsevier Ltd</publisher><subject>Administration, Oral ; Animals ; Arecaceae - chemistry ; Arecaceae - toxicity ; Attalea phalerata Mart ; Bacuri ; Bioactive compounds ; Carotenoids ; Dose-Response Relationship, Drug ; Fatty acids ; Female ; Food science ; Fruit - chemistry ; Fruit - toxicity ; Lethal Dose 50 ; Male ; Plant Oils - administration &amp; dosage ; Plant Oils - isolation &amp; purification ; Plant Oils - toxicity ; Rats, Wistar ; Risk Assessment ; Time Factors ; Toxicity Tests, Acute ; Toxicity Tests, Subacute ; Toxicology</subject><ispartof>Food research international, 2017-01, Vol.91, p.11-17</ispartof><rights>2016 Elsevier Ltd</rights><rights>Copyright © 2016 Elsevier Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c431t-5974667b6b63944cd2570a99ddca805e08ef163d9d8a9e9eecf0f963cd3a54983</citedby><cites>FETCH-LOGICAL-c431t-5974667b6b63944cd2570a99ddca805e08ef163d9d8a9e9eecf0f963cd3a54983</cites><orcidid>0000-0001-5889-8165</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0963996916305592$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28290314$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Freitas de Lima, Fernando</creatorcontrib><creatorcontrib>Traesel, Giseli Karenina</creatorcontrib><creatorcontrib>Menegati, Sara Emilia Lima Tolouei</creatorcontrib><creatorcontrib>Santos, Ariany Carvalho dos</creatorcontrib><creatorcontrib>Souza, Roosevelt Isaias Carvalho</creatorcontrib><creatorcontrib>de Oliveira, Vinícius Soares</creatorcontrib><creatorcontrib>Sanjinez-Argandoña, Eliana Janet</creatorcontrib><creatorcontrib>Cardoso, Claudia Andrea Lima</creatorcontrib><creatorcontrib>Oesterreich, Silvia Aparecida</creatorcontrib><creatorcontrib>Vieira, Maria do Carmo</creatorcontrib><title>Acute and subacute oral toxicity assessment of the oil extracted from Attalea phalerata Mart ex Spreng. pulp fruit in rats</title><title>Food research international</title><addtitle>Food Res Int</addtitle><description>Attalea phalerata Mart. ex Spreng., popularly known as “bacuri”, is a native plant from the brazilian Cerrado and used in folk medicine as a pulmonary decongestant, an anti-inflammatory for joints and antipyretic. There is an expectation about the use in chronic disease of the Attalea phalerata oil since its composition is high in carotenoids and beneficial fatty acids. The aim of the study was to evaluate the toxicological profile of the oil extracted from Attalea phalerata Mart. ex Spreng. pulp (APO). Acute and subacute toxicity studies were performed in male and female Wistar rats according to the OECD - Guidelines 425 and 407. For the acute toxicity, one single dose of the APO (2000mg/kg) was administered by gavage to five female rats. In the subacute toxicity, four different doses (125, 250, 500 and 1000mg/kg) of the APO were administered to male and female rats for 28 consecutive days. No deaths or behavioral changes were observed during both experiments as well as no changes in organ weights, hematological, histopathological parameters. The biochemical parameters showed changes in phosphatase alkaline and albumin levels, however these values are within the normal range for the species. A significant reduction in cholesterol and triglycerides was also observed in some of the animals treated with the APO. Therefore, the LD50 is higher than 2000mg/kg and the APO oil can be considered safe at the doses tested in rats. However, further assessments are required in order to proceed to clinical studies in humans. [Display omitted] •Oral acute and sub-acute toxicities of Attalea phalerata Mart. ex Spreng oil were studied.•The fruit has a high content of carotenoids and healthy fatty acids.•The organs of the animals had a normal size and no macroscopic change.•Toxic changes were not observed in biochemical and hematological parameters.•The pulp oil does not affect the histological parameters.</description><subject>Administration, Oral</subject><subject>Animals</subject><subject>Arecaceae - chemistry</subject><subject>Arecaceae - toxicity</subject><subject>Attalea phalerata Mart</subject><subject>Bacuri</subject><subject>Bioactive compounds</subject><subject>Carotenoids</subject><subject>Dose-Response Relationship, Drug</subject><subject>Fatty acids</subject><subject>Female</subject><subject>Food science</subject><subject>Fruit - chemistry</subject><subject>Fruit - toxicity</subject><subject>Lethal Dose 50</subject><subject>Male</subject><subject>Plant Oils - administration &amp; dosage</subject><subject>Plant Oils - isolation &amp; purification</subject><subject>Plant Oils - toxicity</subject><subject>Rats, Wistar</subject><subject>Risk Assessment</subject><subject>Time Factors</subject><subject>Toxicity Tests, Acute</subject><subject>Toxicity Tests, Subacute</subject><subject>Toxicology</subject><issn>0963-9969</issn><issn>1873-7145</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkMFO3DAQhq0KVBbaR2jlI5ekdhI78alaIVqQQByAszVrT4pXSZzaDmL79JjutldOo9F8M6P_I-QLZyVnXH7blr33NmAsq9yWnJeMqw9kxbu2LlreiCOyYkrWhVJSnZDTGLeMMSla9ZGcVF2lWM2bFfmzNktCCpOlcdnA38YHGGjyL864tKMQI8Y44pSo72l6ynM3UHxJAUxCS_vgR7pOCQYEOj_lEiABvYWQMkXv54DTr5LOyzBndnGJuolmJH4ixz0MET8f6hl5_HH5cHFV3Nz9vL5Y3xSmqXkqhGobKduN3MhaNY2xlWgZKGWtgY4JZB32XNZW2Q4UKkTTsz4HN7YG0aiuPiPn-7tz8L8XjEmPLhocBpjQL1FnY62oukaIjIo9aoKPMWCv5-BGCDvNmX7Trrf6oF2_adec66w97309vFg2I9r_W_88Z-D7HsAc9Nlh0NE4nAxaF9Akbb1758UrZieYKg</recordid><startdate>201701</startdate><enddate>201701</enddate><creator>Freitas de Lima, Fernando</creator><creator>Traesel, Giseli Karenina</creator><creator>Menegati, Sara Emilia Lima Tolouei</creator><creator>Santos, Ariany Carvalho dos</creator><creator>Souza, Roosevelt Isaias Carvalho</creator><creator>de Oliveira, Vinícius Soares</creator><creator>Sanjinez-Argandoña, Eliana Janet</creator><creator>Cardoso, Claudia Andrea Lima</creator><creator>Oesterreich, Silvia Aparecida</creator><creator>Vieira, Maria do Carmo</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-5889-8165</orcidid></search><sort><creationdate>201701</creationdate><title>Acute and subacute oral toxicity assessment of the oil extracted from Attalea phalerata Mart ex Spreng. pulp fruit in rats</title><author>Freitas de Lima, Fernando ; Traesel, Giseli Karenina ; Menegati, Sara Emilia Lima Tolouei ; Santos, Ariany Carvalho dos ; Souza, Roosevelt Isaias Carvalho ; de Oliveira, Vinícius Soares ; Sanjinez-Argandoña, Eliana Janet ; Cardoso, Claudia Andrea Lima ; Oesterreich, Silvia Aparecida ; Vieira, Maria do Carmo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c431t-5974667b6b63944cd2570a99ddca805e08ef163d9d8a9e9eecf0f963cd3a54983</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Administration, Oral</topic><topic>Animals</topic><topic>Arecaceae - chemistry</topic><topic>Arecaceae - toxicity</topic><topic>Attalea phalerata Mart</topic><topic>Bacuri</topic><topic>Bioactive compounds</topic><topic>Carotenoids</topic><topic>Dose-Response Relationship, Drug</topic><topic>Fatty acids</topic><topic>Female</topic><topic>Food science</topic><topic>Fruit - chemistry</topic><topic>Fruit - toxicity</topic><topic>Lethal Dose 50</topic><topic>Male</topic><topic>Plant Oils - administration &amp; dosage</topic><topic>Plant Oils - isolation &amp; purification</topic><topic>Plant Oils - toxicity</topic><topic>Rats, Wistar</topic><topic>Risk Assessment</topic><topic>Time Factors</topic><topic>Toxicity Tests, Acute</topic><topic>Toxicity Tests, Subacute</topic><topic>Toxicology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Freitas de Lima, Fernando</creatorcontrib><creatorcontrib>Traesel, Giseli Karenina</creatorcontrib><creatorcontrib>Menegati, Sara Emilia Lima Tolouei</creatorcontrib><creatorcontrib>Santos, Ariany Carvalho dos</creatorcontrib><creatorcontrib>Souza, Roosevelt Isaias Carvalho</creatorcontrib><creatorcontrib>de Oliveira, Vinícius Soares</creatorcontrib><creatorcontrib>Sanjinez-Argandoña, Eliana Janet</creatorcontrib><creatorcontrib>Cardoso, Claudia Andrea Lima</creatorcontrib><creatorcontrib>Oesterreich, Silvia Aparecida</creatorcontrib><creatorcontrib>Vieira, Maria do Carmo</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Food research international</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Freitas de Lima, Fernando</au><au>Traesel, Giseli Karenina</au><au>Menegati, Sara Emilia Lima Tolouei</au><au>Santos, Ariany Carvalho dos</au><au>Souza, Roosevelt Isaias Carvalho</au><au>de Oliveira, Vinícius Soares</au><au>Sanjinez-Argandoña, Eliana Janet</au><au>Cardoso, Claudia Andrea Lima</au><au>Oesterreich, Silvia Aparecida</au><au>Vieira, Maria do Carmo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Acute and subacute oral toxicity assessment of the oil extracted from Attalea phalerata Mart ex Spreng. pulp fruit in rats</atitle><jtitle>Food research international</jtitle><addtitle>Food Res Int</addtitle><date>2017-01</date><risdate>2017</risdate><volume>91</volume><spage>11</spage><epage>17</epage><pages>11-17</pages><issn>0963-9969</issn><eissn>1873-7145</eissn><abstract>Attalea phalerata Mart. ex Spreng., popularly known as “bacuri”, is a native plant from the brazilian Cerrado and used in folk medicine as a pulmonary decongestant, an anti-inflammatory for joints and antipyretic. There is an expectation about the use in chronic disease of the Attalea phalerata oil since its composition is high in carotenoids and beneficial fatty acids. The aim of the study was to evaluate the toxicological profile of the oil extracted from Attalea phalerata Mart. ex Spreng. pulp (APO). Acute and subacute toxicity studies were performed in male and female Wistar rats according to the OECD - Guidelines 425 and 407. For the acute toxicity, one single dose of the APO (2000mg/kg) was administered by gavage to five female rats. In the subacute toxicity, four different doses (125, 250, 500 and 1000mg/kg) of the APO were administered to male and female rats for 28 consecutive days. No deaths or behavioral changes were observed during both experiments as well as no changes in organ weights, hematological, histopathological parameters. The biochemical parameters showed changes in phosphatase alkaline and albumin levels, however these values are within the normal range for the species. A significant reduction in cholesterol and triglycerides was also observed in some of the animals treated with the APO. Therefore, the LD50 is higher than 2000mg/kg and the APO oil can be considered safe at the doses tested in rats. However, further assessments are required in order to proceed to clinical studies in humans. [Display omitted] •Oral acute and sub-acute toxicities of Attalea phalerata Mart. ex Spreng oil were studied.•The fruit has a high content of carotenoids and healthy fatty acids.•The organs of the animals had a normal size and no macroscopic change.•Toxic changes were not observed in biochemical and hematological parameters.•The pulp oil does not affect the histological parameters.</abstract><cop>Canada</cop><pub>Elsevier Ltd</pub><pmid>28290314</pmid><doi>10.1016/j.foodres.2016.11.019</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0001-5889-8165</orcidid></addata></record>
fulltext fulltext
identifier ISSN: 0963-9969
ispartof Food research international, 2017-01, Vol.91, p.11-17
issn 0963-9969
1873-7145
language eng
recordid cdi_proquest_miscellaneous_1877528455
source MEDLINE; Elsevier ScienceDirect Journals
subjects Administration, Oral
Animals
Arecaceae - chemistry
Arecaceae - toxicity
Attalea phalerata Mart
Bacuri
Bioactive compounds
Carotenoids
Dose-Response Relationship, Drug
Fatty acids
Female
Food science
Fruit - chemistry
Fruit - toxicity
Lethal Dose 50
Male
Plant Oils - administration & dosage
Plant Oils - isolation & purification
Plant Oils - toxicity
Rats, Wistar
Risk Assessment
Time Factors
Toxicity Tests, Acute
Toxicity Tests, Subacute
Toxicology
title Acute and subacute oral toxicity assessment of the oil extracted from Attalea phalerata Mart ex Spreng. pulp fruit in rats
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-31T11%3A57%3A21IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Acute%20and%20subacute%20oral%20toxicity%20assessment%20of%20the%20oil%20extracted%20from%20Attalea%20phalerata%20Mart%20ex%20Spreng.%20pulp%20fruit%20in%20rats&rft.jtitle=Food%20research%20international&rft.au=Freitas%20de%20Lima,%20Fernando&rft.date=2017-01&rft.volume=91&rft.spage=11&rft.epage=17&rft.pages=11-17&rft.issn=0963-9969&rft.eissn=1873-7145&rft_id=info:doi/10.1016/j.foodres.2016.11.019&rft_dat=%3Cproquest_cross%3E1877528455%3C/proquest_cross%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=1877528455&rft_id=info:pmid/28290314&rft_els_id=S0963996916305592&rfr_iscdi=true