Acute and subacute oral toxicity assessment of the oil extracted from Attalea phalerata Mart ex Spreng. pulp fruit in rats
Attalea phalerata Mart. ex Spreng., popularly known as “bacuri”, is a native plant from the brazilian Cerrado and used in folk medicine as a pulmonary decongestant, an anti-inflammatory for joints and antipyretic. There is an expectation about the use in chronic disease of the Attalea phalerata oil...
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creator | Freitas de Lima, Fernando Traesel, Giseli Karenina Menegati, Sara Emilia Lima Tolouei Santos, Ariany Carvalho dos Souza, Roosevelt Isaias Carvalho de Oliveira, Vinícius Soares Sanjinez-Argandoña, Eliana Janet Cardoso, Claudia Andrea Lima Oesterreich, Silvia Aparecida Vieira, Maria do Carmo |
description | Attalea phalerata Mart. ex Spreng., popularly known as “bacuri”, is a native plant from the brazilian Cerrado and used in folk medicine as a pulmonary decongestant, an anti-inflammatory for joints and antipyretic. There is an expectation about the use in chronic disease of the Attalea phalerata oil since its composition is high in carotenoids and beneficial fatty acids. The aim of the study was to evaluate the toxicological profile of the oil extracted from Attalea phalerata Mart. ex Spreng. pulp (APO). Acute and subacute toxicity studies were performed in male and female Wistar rats according to the OECD - Guidelines 425 and 407. For the acute toxicity, one single dose of the APO (2000mg/kg) was administered by gavage to five female rats. In the subacute toxicity, four different doses (125, 250, 500 and 1000mg/kg) of the APO were administered to male and female rats for 28 consecutive days. No deaths or behavioral changes were observed during both experiments as well as no changes in organ weights, hematological, histopathological parameters. The biochemical parameters showed changes in phosphatase alkaline and albumin levels, however these values are within the normal range for the species. A significant reduction in cholesterol and triglycerides was also observed in some of the animals treated with the APO. Therefore, the LD50 is higher than 2000mg/kg and the APO oil can be considered safe at the doses tested in rats. However, further assessments are required in order to proceed to clinical studies in humans.
[Display omitted]
•Oral acute and sub-acute toxicities of Attalea phalerata Mart. ex Spreng oil were studied.•The fruit has a high content of carotenoids and healthy fatty acids.•The organs of the animals had a normal size and no macroscopic change.•Toxic changes were not observed in biochemical and hematological parameters.•The pulp oil does not affect the histological parameters. |
doi_str_mv | 10.1016/j.foodres.2016.11.019 |
format | Article |
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[Display omitted]
•Oral acute and sub-acute toxicities of Attalea phalerata Mart. ex Spreng oil were studied.•The fruit has a high content of carotenoids and healthy fatty acids.•The organs of the animals had a normal size and no macroscopic change.•Toxic changes were not observed in biochemical and hematological parameters.•The pulp oil does not affect the histological parameters.</description><identifier>ISSN: 0963-9969</identifier><identifier>EISSN: 1873-7145</identifier><identifier>DOI: 10.1016/j.foodres.2016.11.019</identifier><identifier>PMID: 28290314</identifier><language>eng</language><publisher>Canada: Elsevier Ltd</publisher><subject>Administration, Oral ; Animals ; Arecaceae - chemistry ; Arecaceae - toxicity ; Attalea phalerata Mart ; Bacuri ; Bioactive compounds ; Carotenoids ; Dose-Response Relationship, Drug ; Fatty acids ; Female ; Food science ; Fruit - chemistry ; Fruit - toxicity ; Lethal Dose 50 ; Male ; Plant Oils - administration & dosage ; Plant Oils - isolation & purification ; Plant Oils - toxicity ; Rats, Wistar ; Risk Assessment ; Time Factors ; Toxicity Tests, Acute ; Toxicity Tests, Subacute ; Toxicology</subject><ispartof>Food research international, 2017-01, Vol.91, p.11-17</ispartof><rights>2016 Elsevier Ltd</rights><rights>Copyright © 2016 Elsevier Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c431t-5974667b6b63944cd2570a99ddca805e08ef163d9d8a9e9eecf0f963cd3a54983</citedby><cites>FETCH-LOGICAL-c431t-5974667b6b63944cd2570a99ddca805e08ef163d9d8a9e9eecf0f963cd3a54983</cites><orcidid>0000-0001-5889-8165</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.sciencedirect.com/science/article/pii/S0963996916305592$$EHTML$$P50$$Gelsevier$$H</linktohtml><link.rule.ids>314,776,780,3537,27901,27902,65306</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/28290314$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Freitas de Lima, Fernando</creatorcontrib><creatorcontrib>Traesel, Giseli Karenina</creatorcontrib><creatorcontrib>Menegati, Sara Emilia Lima Tolouei</creatorcontrib><creatorcontrib>Santos, Ariany Carvalho dos</creatorcontrib><creatorcontrib>Souza, Roosevelt Isaias Carvalho</creatorcontrib><creatorcontrib>de Oliveira, Vinícius Soares</creatorcontrib><creatorcontrib>Sanjinez-Argandoña, Eliana Janet</creatorcontrib><creatorcontrib>Cardoso, Claudia Andrea Lima</creatorcontrib><creatorcontrib>Oesterreich, Silvia Aparecida</creatorcontrib><creatorcontrib>Vieira, Maria do Carmo</creatorcontrib><title>Acute and subacute oral toxicity assessment of the oil extracted from Attalea phalerata Mart ex Spreng. pulp fruit in rats</title><title>Food research international</title><addtitle>Food Res Int</addtitle><description>Attalea phalerata Mart. ex Spreng., popularly known as “bacuri”, is a native plant from the brazilian Cerrado and used in folk medicine as a pulmonary decongestant, an anti-inflammatory for joints and antipyretic. There is an expectation about the use in chronic disease of the Attalea phalerata oil since its composition is high in carotenoids and beneficial fatty acids. The aim of the study was to evaluate the toxicological profile of the oil extracted from Attalea phalerata Mart. ex Spreng. pulp (APO). Acute and subacute toxicity studies were performed in male and female Wistar rats according to the OECD - Guidelines 425 and 407. For the acute toxicity, one single dose of the APO (2000mg/kg) was administered by gavage to five female rats. In the subacute toxicity, four different doses (125, 250, 500 and 1000mg/kg) of the APO were administered to male and female rats for 28 consecutive days. No deaths or behavioral changes were observed during both experiments as well as no changes in organ weights, hematological, histopathological parameters. The biochemical parameters showed changes in phosphatase alkaline and albumin levels, however these values are within the normal range for the species. A significant reduction in cholesterol and triglycerides was also observed in some of the animals treated with the APO. Therefore, the LD50 is higher than 2000mg/kg and the APO oil can be considered safe at the doses tested in rats. However, further assessments are required in order to proceed to clinical studies in humans.
[Display omitted]
•Oral acute and sub-acute toxicities of Attalea phalerata Mart. ex Spreng oil were studied.•The fruit has a high content of carotenoids and healthy fatty acids.•The organs of the animals had a normal size and no macroscopic change.•Toxic changes were not observed in biochemical and hematological parameters.•The pulp oil does not affect the histological parameters.</description><subject>Administration, Oral</subject><subject>Animals</subject><subject>Arecaceae - chemistry</subject><subject>Arecaceae - toxicity</subject><subject>Attalea phalerata Mart</subject><subject>Bacuri</subject><subject>Bioactive compounds</subject><subject>Carotenoids</subject><subject>Dose-Response Relationship, Drug</subject><subject>Fatty acids</subject><subject>Female</subject><subject>Food science</subject><subject>Fruit - chemistry</subject><subject>Fruit - toxicity</subject><subject>Lethal Dose 50</subject><subject>Male</subject><subject>Plant Oils - administration & dosage</subject><subject>Plant Oils - isolation & purification</subject><subject>Plant Oils - toxicity</subject><subject>Rats, Wistar</subject><subject>Risk Assessment</subject><subject>Time Factors</subject><subject>Toxicity Tests, Acute</subject><subject>Toxicity Tests, Subacute</subject><subject>Toxicology</subject><issn>0963-9969</issn><issn>1873-7145</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2017</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNqFkMFO3DAQhq0KVBbaR2jlI5ekdhI78alaIVqQQByAszVrT4pXSZzaDmL79JjutldOo9F8M6P_I-QLZyVnXH7blr33NmAsq9yWnJeMqw9kxbu2LlreiCOyYkrWhVJSnZDTGLeMMSla9ZGcVF2lWM2bFfmzNktCCpOlcdnA38YHGGjyL864tKMQI8Y44pSo72l6ynM3UHxJAUxCS_vgR7pOCQYEOj_lEiABvYWQMkXv54DTr5LOyzBndnGJuolmJH4ixz0MET8f6hl5_HH5cHFV3Nz9vL5Y3xSmqXkqhGobKduN3MhaNY2xlWgZKGWtgY4JZB32XNZW2Q4UKkTTsz4HN7YG0aiuPiPn-7tz8L8XjEmPLhocBpjQL1FnY62oukaIjIo9aoKPMWCv5-BGCDvNmX7Trrf6oF2_adec66w97309vFg2I9r_W_88Z-D7HsAc9Nlh0NE4nAxaF9Akbb1758UrZieYKg</recordid><startdate>201701</startdate><enddate>201701</enddate><creator>Freitas de Lima, Fernando</creator><creator>Traesel, Giseli Karenina</creator><creator>Menegati, Sara Emilia Lima Tolouei</creator><creator>Santos, Ariany Carvalho dos</creator><creator>Souza, Roosevelt Isaias Carvalho</creator><creator>de Oliveira, Vinícius Soares</creator><creator>Sanjinez-Argandoña, Eliana Janet</creator><creator>Cardoso, Claudia Andrea Lima</creator><creator>Oesterreich, Silvia Aparecida</creator><creator>Vieira, Maria do Carmo</creator><general>Elsevier Ltd</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0001-5889-8165</orcidid></search><sort><creationdate>201701</creationdate><title>Acute and subacute oral toxicity assessment of the oil extracted from Attalea phalerata Mart ex Spreng. pulp fruit in rats</title><author>Freitas de Lima, Fernando ; Traesel, Giseli Karenina ; Menegati, Sara Emilia Lima Tolouei ; Santos, Ariany Carvalho dos ; Souza, Roosevelt Isaias Carvalho ; de Oliveira, Vinícius Soares ; Sanjinez-Argandoña, Eliana Janet ; Cardoso, Claudia Andrea Lima ; Oesterreich, Silvia Aparecida ; Vieira, Maria do Carmo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c431t-5974667b6b63944cd2570a99ddca805e08ef163d9d8a9e9eecf0f963cd3a54983</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2017</creationdate><topic>Administration, Oral</topic><topic>Animals</topic><topic>Arecaceae - chemistry</topic><topic>Arecaceae - toxicity</topic><topic>Attalea phalerata Mart</topic><topic>Bacuri</topic><topic>Bioactive compounds</topic><topic>Carotenoids</topic><topic>Dose-Response Relationship, Drug</topic><topic>Fatty acids</topic><topic>Female</topic><topic>Food science</topic><topic>Fruit - chemistry</topic><topic>Fruit - toxicity</topic><topic>Lethal Dose 50</topic><topic>Male</topic><topic>Plant Oils - administration & dosage</topic><topic>Plant Oils - isolation & purification</topic><topic>Plant Oils - toxicity</topic><topic>Rats, Wistar</topic><topic>Risk Assessment</topic><topic>Time Factors</topic><topic>Toxicity Tests, Acute</topic><topic>Toxicity Tests, Subacute</topic><topic>Toxicology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Freitas de Lima, Fernando</creatorcontrib><creatorcontrib>Traesel, Giseli Karenina</creatorcontrib><creatorcontrib>Menegati, Sara Emilia Lima Tolouei</creatorcontrib><creatorcontrib>Santos, Ariany Carvalho dos</creatorcontrib><creatorcontrib>Souza, Roosevelt Isaias Carvalho</creatorcontrib><creatorcontrib>de Oliveira, Vinícius Soares</creatorcontrib><creatorcontrib>Sanjinez-Argandoña, Eliana Janet</creatorcontrib><creatorcontrib>Cardoso, Claudia Andrea Lima</creatorcontrib><creatorcontrib>Oesterreich, Silvia Aparecida</creatorcontrib><creatorcontrib>Vieira, Maria do Carmo</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Food research international</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Freitas de Lima, Fernando</au><au>Traesel, Giseli Karenina</au><au>Menegati, Sara Emilia Lima Tolouei</au><au>Santos, Ariany Carvalho dos</au><au>Souza, Roosevelt Isaias Carvalho</au><au>de Oliveira, Vinícius Soares</au><au>Sanjinez-Argandoña, Eliana Janet</au><au>Cardoso, Claudia Andrea Lima</au><au>Oesterreich, Silvia Aparecida</au><au>Vieira, Maria do Carmo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Acute and subacute oral toxicity assessment of the oil extracted from Attalea phalerata Mart ex Spreng. pulp fruit in rats</atitle><jtitle>Food research international</jtitle><addtitle>Food Res Int</addtitle><date>2017-01</date><risdate>2017</risdate><volume>91</volume><spage>11</spage><epage>17</epage><pages>11-17</pages><issn>0963-9969</issn><eissn>1873-7145</eissn><abstract>Attalea phalerata Mart. ex Spreng., popularly known as “bacuri”, is a native plant from the brazilian Cerrado and used in folk medicine as a pulmonary decongestant, an anti-inflammatory for joints and antipyretic. There is an expectation about the use in chronic disease of the Attalea phalerata oil since its composition is high in carotenoids and beneficial fatty acids. The aim of the study was to evaluate the toxicological profile of the oil extracted from Attalea phalerata Mart. ex Spreng. pulp (APO). Acute and subacute toxicity studies were performed in male and female Wistar rats according to the OECD - Guidelines 425 and 407. For the acute toxicity, one single dose of the APO (2000mg/kg) was administered by gavage to five female rats. In the subacute toxicity, four different doses (125, 250, 500 and 1000mg/kg) of the APO were administered to male and female rats for 28 consecutive days. No deaths or behavioral changes were observed during both experiments as well as no changes in organ weights, hematological, histopathological parameters. The biochemical parameters showed changes in phosphatase alkaline and albumin levels, however these values are within the normal range for the species. A significant reduction in cholesterol and triglycerides was also observed in some of the animals treated with the APO. Therefore, the LD50 is higher than 2000mg/kg and the APO oil can be considered safe at the doses tested in rats. However, further assessments are required in order to proceed to clinical studies in humans.
[Display omitted]
•Oral acute and sub-acute toxicities of Attalea phalerata Mart. ex Spreng oil were studied.•The fruit has a high content of carotenoids and healthy fatty acids.•The organs of the animals had a normal size and no macroscopic change.•Toxic changes were not observed in biochemical and hematological parameters.•The pulp oil does not affect the histological parameters.</abstract><cop>Canada</cop><pub>Elsevier Ltd</pub><pmid>28290314</pmid><doi>10.1016/j.foodres.2016.11.019</doi><tpages>7</tpages><orcidid>https://orcid.org/0000-0001-5889-8165</orcidid></addata></record> |
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subjects | Administration, Oral Animals Arecaceae - chemistry Arecaceae - toxicity Attalea phalerata Mart Bacuri Bioactive compounds Carotenoids Dose-Response Relationship, Drug Fatty acids Female Food science Fruit - chemistry Fruit - toxicity Lethal Dose 50 Male Plant Oils - administration & dosage Plant Oils - isolation & purification Plant Oils - toxicity Rats, Wistar Risk Assessment Time Factors Toxicity Tests, Acute Toxicity Tests, Subacute Toxicology |
title | Acute and subacute oral toxicity assessment of the oil extracted from Attalea phalerata Mart ex Spreng. pulp fruit in rats |
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